Tom Hanks Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry Halle Berry Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym Götz Otto Groundsman Withers Jim Broadbent Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2 Hugo Weaving Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie Jim Sturgess Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law Bae Doona Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute Ben Whishaw Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman James D'Arcy Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist 周迅 (Zhou Xun) Talbot / Hotel Manager / Yoona-939 / Rose Keith David Kupaka / Joe Napier / An-kor Apis / Prescient David Gyasi Autua / Lester Rey / Duophsyte Susan Sarandon Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess Hugh Grant Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief Robert Fyfe Old Salty Dog / Mr. Meeks / Prescient 1 Martin Wuttke Mr. Boerhaave / Guard / Leary the Healer Zhu Zhu Megan Sixsmith / 12th Star Clone Alistair Petrie Haskell Moore's Dinner Guest / Musician / Felix Finch / Lascivious Businessman Sylvestra Le Touzel Haskell Moore's Dinner Guest / Nurse Judd / Aide in Slaughtership Shaun Lawton Secretary