Au Népal, un dénommé Kaecilius, maître des arts mystiques, s'introduit avec ses comparses dans la bibliothèque du sanctuaire de Kamar-Taj afin de s’emparer de deux pages du livre de Cagliostro, après avoir tué le bibliothécaire. L’Ancien tente d’arrêter son ex-élève mais échoue, son disciple parvenant à fuir.
Dr. Malcolm Crowe, a child psychologist in Philadelphia, returns home one night with his wife, Anna, after having been honored for his work. Anna tells Malcolm that everything is second to his work, and that she believes he is truly gifted.
The planet Krypton faces imminent destruction due to its unstable core; the result of depleting Krypton's natural resources. The ruling council is deposed by the planet's military commander, General Zod, and his followers during a coup d'état. Knowing that artificial population control and isolationism have ruined their civilization, scientist Jor-El and his wife Lara launch their newborn son, Kal-El, the first naturally born Kryptonian child in centuries, on a spacecraft to Earth after infusing his cells with a genetic codex of the entire Kryptonian race. After Zod kills Jor-El, he and his followers are captured and exiled to the Phantom Zone. However, they are indirectly freed after Krypton explodes, rendering the Kryptonian race extinct apart from Zod and his forces.
Sailing to Port Royal, Governor Weatherby Swann, his daughter Elizabeth, and Lieutenant James Norrington encounter a burning shipwreck and recover a young boy Will Turner. Elizabeth hides a golden medallion owned by Will, and sees a ghost ship vanishing into the fog. Eight years on, Norrington is promoted to the rank of Commodore and proposes to Elizabeth, but her tight corset causes her to faint and fall into the sea. She is rescued by Captain Jack Sparrow, who Norrington identifies as a pirate who intends on commandeering a ship. Jack attempts to escape but runs into Will, now a blacksmith and a talented swordsman. They engage in a sword fight but Jack is captured by Norrington’s men and imprisoned.
En 1927, quelques mois seulement après son arrestation par le Congrès magique des États-Unis, Gellert Grindelwald s'évade et souhaite rassembler des sorciers de « sang-pur » afin de régner sur l’ensemble de la population non magique. Albus Dumbledore, un professeur renommé de l'école de sorcellerie britannique de Poudlard, et ancien ami d'enfance de Grindelwald, semble le seul en mesure de l'arrêter.
John Hancock (Will Smith) is an alcoholic man with superhero powers, including flight, invulnerability, and super-strength. Though he uses his powers to stop criminals in his current residence of Los Angeles, his activity inadvertently causes millions of dollars in property damage due to his constant intoxication. As a result, he is routinely jeered at the crime scenes. Hancock also ignores court subpoenas from the city of Los Angeles to address the property damage he has caused.
In 2012, an alien criminal, Boris the Animal, a Boglodite, escapes from a maximum-security prison on the moon and arrives on Earth, bent on taking revenge on Agent K, who shot off his left arm and captured him in 1969. He confronts K, who is with his partner Agent J, telling him he is "already dead". J then discovers that K was responsible not only for capturing Boris, but for deploying the "ArcNet", a shield that prevented the Boglodites from conquering Earth and caused their extinction.
In Russia, the media covers Tony Stark's disclosure of his identity as Iron Man. Ivan Vanko, whose father Anton Vanko has just died, sees this and begins building a miniature arc reactor similar to Stark's. Six months later, Stark is a superstar and uses his Iron Man suit for peaceful means, resisting government pressure to sell his designs. He re-institutes the Stark Expo in Flushing Meadows to continue his father Howard's legacy.
Four years after the disaster at Jurassic Park, the wealthy Bowman family makes an excursion to the island of Isla Sorna during a yachting cruise. Their young daughter wanders off and is attacked by a pack of Compsognathus, but survives. The incident allows Peter Ludlow, John Hammond's nephew, to gain control of his uncle's company InGen, which is in severe financial straits after the events at Jurassic Park. Hammond contacts Ian Malcolm and explains that Isla Sorna is the island where the dinosaurs were engineered and nurtured before being moved to Isla Nublar, Jurassic Park's location. He also explains that after the park was shut down, Isla Sorna was abandoned during a hurricane and the dinosaurs left to survive in the wild, where they have been inexplicably thriving. Hammond asks Malcolm to join a team that will travel to Isla Sorna to document the dinosaurs in order to rally public support against human interference on the island. Ian initially declines but, after learning that his girlfriend, paleontologist Sarah Harding, is part of the team and is already on the island, he agrees to go.
Larry Daley (Ben Stiller) is divorced, unable to keep a stable job, and has failed at many business ventures. His ex-wife (Kim Raver) believes that he is a bad example to their ten-year-old son Nick (Jake Cherry), and Larry fears that Nick respects his future stepfather, bond trader Don (Paul Rudd), more than him.
En 1944, alors que la guerre du Pacifique fait rage, deux pilotes s'écrasent sur une île inconnue. L'un est Américain, l'autre est Japonais. Alors qu'ils s'affrontent sur place, ils sont brusquement interrompus par une gigantesque créature.
As the Smurfs get ready for the Blue Moon Festival, Papa Smurf sees in his cauldron a vision of Clumsy Smurf reaching for a dragon wand and the Smurfs in cages while Gargamel laughs. Not wanting this vision to come true, Papa Smurf disallows Clumsy to pick Smurf Roots. Clumsy disobeys Papa and ends up unintentionally leading Gargamel and Azrael to the village. The Smurfs all flee for their lives while Clumsy unknowingly runs towards the Forbidden Falls, with Papa Smurf, Smurfette, Grouchy, Brainy and Gutsy running after him. They find him at the edge of a cliff, and while trying to help him up, they are sucked into a gigantic vortex that spirits them to present day New York City. To make matters worse, Gargamel and Azrael follow and the Smurfs end up in the apartment of Patrick and Grace Winslow, a married and expectant couple and their Basset Hound Elway. After clarifying things, the Winslows befriend them and allow them to stay in their apartment. The next day, needing to find a "star gazer" (a telescope), the Smurfs follow Patrick to his work place at Anjelou Cosmetics, misunderstanding the previous explanation of his job as fortune-telling. He calls Grace to pick them up.
In 1933, at the height of the Great Depression, New York City vaudeville actress Ann Darrow has lost her job and is hired by financially troubled filmmaker Carl Denham to star in his new film. Ann signs on when she learns her favorite playwright, Jack Driscoll, is the screenwriter. As their tramp steamer, the SS Venture, makes the lengthy journey to the remote and mysterious Skull Island, Ann and Jack fall in love. Captain Englehorn begins having second thoughts about the voyage, prompted by crew speculation of trouble ahead.
In 1985, John Bennett is a lonely child living in Boston, who wished for his new Christmas gift—a large teddy bear named Ted—to come to life and become his friend. The wish coincides with a shooting star and comes true; word spread and Ted was briefly a celebrity.