César Faz (Clifton Collins, Jr.), moves to Monterrey, Mexico after he is let go by the St. Louis Cardinals from his job as a clubhouse attendant. There he meets local children being led by Padre Esteban (Cheech Marin), enjoying baseball; he takes pitcher Ángel Macías (Jake T. Austin), under his wing and brags about his own pitching skills and how he used to coach the Cardinals. Ángel convinces César to help recruit and coach Monterrey's first-ever Little League team. With César's skills and Padre Esteban's support, the boys hone themselves into a competitive team worthy of international competition. At the final game of the World Series of Little League, Monterrey defeated the team of West La Mesa, California 4-0. Enrique Suárez (Jansen Panettiere), hit a grand slam home run, and Ángel Macías pitched a perfect game, a feat that has not since been repeated in Little League World Series history.
Roger Dorn is now the owner of the Minnesota Twins. Aging minor league pitcher Gus Cantrell, who plays for the Fort Myers Miracle, is planning to retire. Then, Roger recruits Gus to be the manager of the Buzz, the Twins' AAA minor league affiliate. Gus's mission is to make a real team out of a bunch of players who include ballet dancer turned ballplayer Lance "The Dance" Pere, minor league lifer Frank "Pops" Morgan, Rube Baker, Taka Tanaka, Pedro Cerrano, pitcher Hog Ellis, home run hitter Billy "Downtown" Anderson, and pitcher Carlton "Doc" Windgate, a medical school graduate who throws the slowest fastball in the minors.
Pro baseball player Cory Brand is forced into a rehabilitation program in his Oklahoma hometown after several alcohol-related incidents. He is responsible for injuring his brother in an alcohol-related crash. Cory reluctantly enters a Celebrate Recovery. He eventually finds new hope when he gets honest about his checkered past, and takes on coaching duties for a Little League team. Cory reunites with his high school girlfriend, starts a relationship with his son and rebuilds his relationship with his family.
Al Percolo (Albert Brooks) is a Major League Baseball scout with the New York Yankees who attends a game at a small college to see pitching phenom Tommy Lacy (Michael Rapaport). Al happens to be a fan of the film King Kong and he remarks to his fellow scouts sitting in the crowd that he is looking for the next King Kong.
Darryl Palmer is a baseball player for the Atlanta Braves. He enjoys the fame and fringe benefits of bachelor life until he meets rock singer Debby Huston, falls in love and decides to settle down.
A college professor is working on a long-term scientific experiment when a baseball comes through the window, destroying all of his glassware and spilling the fluids that the flasks and test tubes contained. The pooled fluids combine to form the (fictitious) chemical "methylethylpropylbutyl," which then covers a large portion of the baseball. The professor soon discovers that the fluid, along with any object with which it makes contact, is repelled by wood (cf. Alexander Fleming's serendipitous discovery of penicillin).
The film follows the lives of a group of gay friends in West Hollywood. Among the group is Dennis (Timothy Olyphant), a photographer who often holds the group together; Cole (Dean Cain) a handsome, charismatic actor who — often unwittingly — ends up with other people's boyfriends; Benji (Zach Braff), the youngest member of the group, with a penchant for gym-bodied men, who finds himself going through some bad times; Howie (Matt McGrath), a psychology student who is known for overthinking every situation; Patrick (Ben Weber), the cynic of the group; and Taylor (Billy Porter), who has just broken up with his long-term boyfriend.
Poor health and alcoholism force Grover Cleveland Alexander out of baseball, but through his wife's faithful efforts, he gets a chance for a comeback and redemption.
With baseball's Pittsburgh Pirates in last place, their combative, foul-mouthed manager Guffy McGovern has plenty to complain about. All this changes when, while wandering through Forbes Field in search of his good luck charm one night, Guffy is accosted by the voice of an angel (voice of James Whitmore), who hints at having been a ballplayer during his earthly life.
A scout for the St. Louis Cardinals comes to a small town in the Ozarks to assess pitcher Jerome Herman Dean (Dailey). Dean, with an over-abundance of self-confidence, is certain that the club wants him to start immediately and is surprised that he is sent to the minor league Houston Buffaloes. Despite his obvious talents, Dean is teased about his rustic clothes and goes to a department store to buy new suits. He meets pretty credit officer Patricia Nash (Dru) and courts her with great vigor. At an exhibition between the Buffaloes and the Chicago White Sox, Dean is dismayed to see Pat with another man but pitches an almost perfect game. The White Sox players razz Dean, calling him "Dizzy," but he adopts the nickname, which is picked up by sports reporters. Dean asks Pat to elope, and although she is stunned by his proposal, agrees to marry him.
The true story of Kent Stock (Sean Astin), who in the early 1990s, takes the job of a lifetime as head coach of the Norway High School baseball team, a school which had won 19 State titles and equated baseball with life. Kent must win over his players and convince them and himself that he can fill their former coach's shoes all while dealing with the reality that this will be the team's final season due to an impending merger with a nearby school.
Miguel "Sugar" Santos (Perez Soto) spends his weekends at home, passing from the landscaped gardens and manicured fields on one side of the guarded academy gate to the underdeveloped, more chaotic world beyond. In his small village outside San Pedro de Macorís, Miguel enjoys a kind of celebrity status. His neighbors gather to welcome him back for the weekend; the children ask him for extra baseballs or an old glove. To his family, who lost their father years before, Miguel is their hope and shining star. With the small bonus he earned when he signed with the academy some time ago, he has started to build his family a new house—one that has a bigger kitchen for his mom and a separate room for his grandmother.
Sportswriter Al Stump is hired in 1960 as ghostwriter of an authorized autobiography of baseball player Tyrus Raymond "Ty" Cobb. Now 73 and in failing health, Cobb wants an official biography to "set the record straight" before he dies.