Andy, now 17 years old, is about to leave for college, and his toys have not been played with for years. He intends to take only Woody with him, and puts Buzz Lightyear, Jessie and the other toys in a bag to be stored in the attic. Andy's mother mistakenly takes the bag to the curb for garbage pickup. The toys escape and, believing Andy intended to throw them away, decide to climb in a donation box with Barbie bound for Sunnyside Daycare. Woody follows them and tries to explain the mistake, but they refuse to believe him.
When the fearsome tiger Shere Khan (Idris Elba) threatens his life, Mowgli (Neel Sethi), a boy raised by wolves, leaves his jungle home and, guided by Bagheera the panther (Ben Kingsley) and the free-spirited bear Baloo (Bill Murray), sets out on a journey of self-discovery.
Two ocellaris clownfish, Marlin and his wife Coral, admire their new home in the Great Barrier Reef and their clutch of eggs when a barracuda attacks, knocking Marlin unconscious. He wakes up to find that Coral and all but one of the eggs have disappeared. Marlin names this last egg Nemo, a name that Coral liked.
Hiro Hamada is a 14-year-old robotics genius in the futuristic fictional city of San Fransokyo. Raised by his aunt Cass and older brother Tadashi after the death of his parents, he spends his time participating in illegal robot fights. To redirect Hiro, Tadashi takes him to the robotics center at his university, where Hiro meets Tadashi's friends: GoGo, Wasabi, Honey Lemon, and Fred, as well as Baymax, the inflatable healthcare companion robot Tadashi created. To enroll in the school, Hiro signs up for the school's science fair and presents microbots: swarms of tiny robots that can link together in any arrangement imaginable. Professor Callaghan, the head of the university's robotics program, is impressed, and grants Hiro entrance to the university. Alastair Krei, renowned entrepreneur and president of Krei Tech, offers to buy the microbots, but Hiro follows Callaghan's warnings about Krei's questionable business practices and declines to sell them. When Tadashi and Hiro later arrive at the university to find it engulfed in flames, Tadashi rushes in to rescue Callaghan, but the building explodes moments later, killing him.
In 2012, an alien criminal, Boris the Animal, a Boglodite, escapes from a maximum-security prison on the moon and arrives on Earth, bent on taking revenge on Agent K, who shot off his left arm and captured him in 1969. He confronts K, who is with his partner Agent J, telling him he is "already dead". J then discovers that K was responsible not only for capturing Boris, but for deploying the "ArcNet", a shield that prevented the Boglodites from conquering Earth and caused their extinction.
Remy is an idealistic and ambitious young rat, gifted with highly developed senses of taste and smell. Inspired by his idol, the recently deceased chef Auguste Gusteau, Remy dreams of becoming a cook himself. When an old woman sees his clan, they are forced to abandon their home; Remy is separated from them as a result of the woman's gunshots. He ends up in the sewers of Paris and eventually finds himself at a skylight overlooking the kitchen of Gusteau's restaurant.
As a cub, Alex the Lion was called Alakay and was the son of Zuba, the alpha lion. Though Zuba tries to teach Alakay to be a hunter, the cub is more interested in dancing, and is captured by poachers when Makunga, Zuba's rival, challenges Zuba to a fight for the position of alpha lion. Alakay is forced into a crate, and taken away despite Zuba's attempts to rescue him. The crate falls into the ocean where it drifts to New York. There, Alakay is renamed Alex and sent to the Central Park Zoo where he grew up, meeting Marty the Zebra, Melman the Giraffe, and Gloria the Hippopotamus. Most of the events of the first film are then described through a series of news flashes.
Agent K and his partner Agent D intercept a truck smuggling illegal immigrants into the United States. Inside they discover an alien disguised as a human. When he runs, they shoot him and use neuralyzers to wipe the memories of the border patrol witnesses. D decides to retire and asks K to wipe his memory too. In upstate New York, an alien crash-lands and kills an abusive farmer named Edgar to use his skin as a disguise.
The parallel city of Monstropolis is inhabited by monsters and powered by the screams of children in the human world. At the factory of Monsters, Inc., employees called "scarers" venture into children's bedrooms to scare them and collect their screams, using closet doors as portals. This is considered a dangerous task because the monsters believe children are toxic and that touching them would be fatal. However, production is falling as children are becoming harder to scare and the company's chairman Henry J. Waternoose III is determined to find a solution. The top scarer is James P. "Sulley" Sullivan, who lives with his friend and assistant Mike Wazowski and has a rivalry with the ever-determined chameleon-like monster Randall Boggs. During an ordinary day's work on what is known as the "Scarefloor", another scarer accidentally brings a child's sock into the factory, causing the Child Detection Agency (CDA) to arrive and cleanse him. Mike is frequently ridiculed by the company's clerk Roz for never completing his paperwork on time.
In 1985, John Bennett is a lonely child living in Boston, who wished for his new Christmas gift—a large teddy bear named Ted—to come to life and become his friend. The wish coincides with a shooting star and comes true; word spread and Ted was briefly a celebrity.
At the Central Park Zoo, Marty the zebra is celebrating his tenth birthday, but longs to see the rest of the world from outside his pampered life at the zoo, believing that he can find wide-open spaces to run around in, like in Connecticut. Marty's best friend, Alex the lion, attempts to cheer up his friend by singing Frank Sinatra's "New York, New York" with him. Still unsatisfied, Marty gets some tips from the zoo's penguins: Skipper, Kowalski, Rico, and Private. The penguins are similarly trying to escape the zoo. Marty's friends — Alex the lion, Melman the giraffe, and Gloria the hippopotamus — realize Marty's folly and try to follow him. The four, along with the penguins and the chimpanzees Mason and his silent friend Phil, eventually find themselves at Grand Central Station, but are quickly sedated by tranquilizer darts when Alex's attempt to communicate with humans is mistaken for aggression. The zoo, under pressure from animal-rights activists, is forced to ship the animals, by sea, to a Kenyan wildlife preserve. During their travels, the penguins escape from their enclosure and take over the ship, intent on taking it to Antarctica. Their antics on the bridge cause the crates containing Alex, Marty, Melman, and Gloria to fall off the boat and wash ashore on Madagascar.
In 1891, London detective Sherlock Holmes (Robert Downey, Jr.) and his partner and flatmate Dr. John Watson (Jude Law) race to prevent the ritual murder of a woman by Lord Blackwood (Mark Strong), who has killed five other young women similarly. They stop the murder before Inspector Lestrade (Eddie Marsan) and the police arrive to arrest Blackwood.
Woody prepares to go to cowboy camp with Andy, but his right arm is accidentally torn. Andy decides to leave him behind, and his mother puts him on a shelf. The next day, Woody discovers that Wheezy, a penguin squeaky toy, has been shelved for months due to a broken squeaker. When Andy's mother puts Wheezy in a yard sale, Woody rescues him, only to be stolen by a greedy toy collector, who takes him to his residential 23-story apartment. Buzz Lightyear and all of Andy's other toys identify the thief from a commercial as Al McWhiggin, the owner of a toy store called Al's Toy Barn. Buzz, Hamm, Mr. Potato Head, Slinky Dog, and Rex all set out to rescue Woody.