Un chauffeur de camion est arrêté sur une petite route par des hommes portant des tenues de protection contre les risques biologiques. Ils désinfectent son véhicule avant de le laisser passer. Peu après, il percute une chevrette qui, bien que morte, se relève.
In Cambridge, three animal liberation activists break into a medical research laboratory with the intent of freeing captive chimpanzees. They are interrupted by a scientist, who desperately warns them that the chimps are infected with a highly contagious rage-inducing virus that is spread through blood and saliva. Ignoring the scientist's pleas, the activists release a chimpanzee, who attacks one of them and immediately infects her — leading her to attack and infect everyone else present.
In 2009, a genetically re-engineered measles virus, originally created as a cure for cancer, turns into a lethal strain which kills 90% of those it infects, and mutates the remaining 10% into predatory, nocturnal mutants called "Darkseekers" who are extremely vulnerable to sunlight and other sources of UV. Three years after the outbreak, US Army virologist Lieutenant Colonel Robert Neville (Will Smith) lives an isolated life in the ruins of New York City, which is now deserted, unsure if any other uninfected humans are left in the world.
A zombie outbreak erupts in metropolitan areas around the world; those bitten by the creatures become zombies themselves within twelve seconds. Retired UN investigator Gerry Lane, his wife Karen, and their two daughters manage to escape the outbreak in Philadelphia and take shelter with a family in Newark while waiting for special evacuation the next day, thanks to Gerry's friend UN Deputy Secretary-General Thierry Umuntoni. They find a shelter for the night while waiting for a rescue helicopter. Their hosts choose not to accompany them when they flee the next day, and are subsequently bitten and changed by zombies. Their son, Tommy, manages to escape, and Gerry's family takes him in. They are flown to an offshore U.S. Navy carrier group near New York where Umuntoni is overseeing the remaining worldwide governments' reactions.
During the original outbreak of the Rage Virus, Don, his wife Alice, and four other survivors hide in a barricaded cottage on the outskirts of London. They hear a terrified boy pounding at their door, and let him in. A few minutes later, they discover that the infected have followed the boy to them. The infected attack and kill most of the survivors, while Don, Alice, and the boy are chased upstairs. Don is separated from Alice and when the boy is seen hiding in the closet. Alice rushes to get the boy, while Don tells her to just leave him. Soon the infected break into the room and after Alice pleading with Don to "help us", he decides to leave, abandoning them. Don desperately sprints to a nearby motorboat and narrowly escapes.
Returning from a Hong Kong business trip, Beth Emhoff has a layover in Chicago to have sex with a former lover before returning to her family in suburban Minneapolis. She appears to have contracted a cold during her trip. Her six-year-old son from a previous marriage, Clark, also becomes symptomatic and is sent home from school. Beth's condition worsens and two days later she collapses with severe seizures. Her husband, Mitch, rushes her to the hospital, but she dies of an unknown cause.
The story centers on the redemption of its lead female character. George Brent is Tom Ransome, an artist who leads a rather dissolute if socially active life in the town of Ranchipur. His routine is shattered with the arrival of his former lover, Lady Edwina Esketh (Myrna Loy) who has since married the elderly Lord Esketh (Nigel Bruce). Lady Edwina first sets out to seduce, then gradually falls in love with, Major Rama Safti (Tyrone Power) who represents the "new India."
A group of illegal immigrants are smuggled from China to South Korea inside a shipping container, but when it's opened in the affluent Seoul suburb of Bundang by traffickers, it's discovered that all of the immigrants are dead, except for one man, a carrier of a deadly strain of H5N1 (avian influenza, or bird flu). As the man escapes, he quickly spreads the virus to nearby residents. Mir (Park Min-ha), daughter of a single mother Kim In-hae (Soo Ae), meets the man, named Mossai, and gives him some food and tells him to wait as she calls rescue worker and paramedic Kang Ji-goo (Jang Hyuk). However as he arrives, Mossai is nowhere to be found.
Underneath Raccoon City exists a genetic research facility called the Hive, owned by the Umbrella Corporation. A thief steals the genetically engineered T-virus and contaminates the Hive with it. In response, the facility's artificial intelligence, the Red Queen, seals the Hive and kills everyone inside.
Motaba, a fictional virus which causes a deadly fever, is discovered in the African jungle in 1967. To keep the virus a secret, U.S. Army officers Donald McClintock (Donald Sutherland) and William Ford (Morgan Freeman) destroy the camp where it was found.
In 1975, biological warfare between China and Russia kills most of the world's population. U.S. Army Col. Robert Neville, M.D. is a scientist based in Los Angeles. As he begins to succumb to the plague himself, he injects himself with an experimental vaccine, rendering himself immune.
A critically injured woman, victim of a motorcycle accident, is taken to the plastic surgery clinic of Doctor Dan Keloid, where some of her intact tissue is treated to become morphogenetically neutral. The tissue is grafted to fire-damaged areas of her body in the hope that it will differentiate and replace the damaged skin and organs.
When the existence of a strain of plague (vaguely identified as pneumonic) is revealed at the U.S. mission at the International Health Organization, three terrorists seek to blow up the U.S. mission. Two of them are shot, one mortally, by security personnel but one escapes. The surviving terrorist is hospitalized and quarantined and identified as Swedish. Dr. Elena Stradner (Ingrid Thulin) and U.S. Colonel Stephen Mackenzie (Burt Lancaster) (Military Intelligence assigned to the IHO) argue over the nature of the strain, which Stradner suspects is a biological weapon but which Colonel Mackenzie claims was in the process of being destroyed.
In 1982, a shady transaction is occurring between an East German scientist, Dr. Krause, and a group of Americans. It is revealed that MM88 is a deadly virus, created accidentally by an American geneticist, that amplifies the potency of any other virus or bacterium it comes into contact with. The Americans recover the MM88, which was stolen from a lab in the US the year before, but the virus is released, creating a pandemic initially known as the "Italian Flu".