Cassiel and Raphaella, two angels, observe the busy life of reunited Berlin. Due to their divine origin, they can hear the thoughts of the people around them, and try to console a dying man. Cassiel has been following his friend Damiel (a former angel), who senses his presence and talks about his experiences as a human. He owns a pizza parlor named Casa dell'angelo (Angel's House) and has married Marion, a trapeze artist whom he met when an angel. She works in a local bar in West Berlin, and the two have a young daughter, Doria.
During his year in the fifth grade, ten-year-old Joshua Beal (Joseph Cross) begins a personal search to find answers about life and death — a journey triggered by the passing of his beloved grandfather (Robert Loggia).
After his release from prison, gangster Eddie Kagle (Paul Muni) is killed by his partner in crime, Smiley Williams (Hardie Albright). Kagle ends up in Hell, where "Nick" (Claude Rains) offers him a chance to escape hell and avenge his own death in exchange for help with a problem. Kagle looks exactly like Judge Frederick Parker, an upright man who is causing Nick distress because he is entirely too honest. Nick fears that Parker may cause him more anxiety in future, as he is running for governor of his state. Nick wants to destroy Parker's reputation and Kagle readily agrees to have his soul transferred into Parker's body.
Squadron Leader Peter Carter (David Niven) is a British Royal Air Force pilot trying to fly a badly damaged and burning Lancaster bomber home after a mission over Germany on 2 May 1945. He has ordered his crew to bail out, without revealing that his own parachute has been shot up. He manages to contact June (Kim Hunter), an American radio operator based in England, and talks with her for a few minutes before jumping without a parachute.
Deux individus que tout oppose se retrouvent malgré-eux enchantés par leur ange gardien : l'un, Carco, malfrat égoïste reconverti, doit ramener de Hong Kong le fils d'un ami trafiquant, mais le fait surtout pour passer les 15 millions de dollars en bons du trésor volés. L'autre, un curé, le père Tarain, honnête et bienveillant, rentre de stage éducatif avec un groupe de jeunes en difficultés.
A mysterious robed figure brings Gabriel back from hell to Earth. His new mission is to prevent the birth of a child, a nephilim, the offspring of an angel and a human. The coming of this child, said to precede reconciliation between the warring factions in heaven, has been prophesied by Thomas Daggett, now a monk. The child's conception takes place when Valerie, a nurse, is seduced by an attractive stranger (the angel Danyael) whom she hit with her car. She finds a few days later that she is pregnant.
Martine and Michel are very much in love and have decided to get married, but one evening, their love is put to the test. Two messengers, a demon and an angel, come to their house. Ben Atkinson (the demon) comes first and offers Michel a good job and money. Martine suspects a trick, but Michel is ready to accept the demon's offer. The angel tries to go for help but is stopped by devil, who uses policemen to back him up. At the end, the angel prevents the demon's plans.
Bishop Henry Brougham (David Niven), troubled with funding the building of a new cathedral, prays for divine guidance. His plea is seemingly answered by a suave angel named Dudley (Cary Grant), who reveals his identity only to the clergyman.
Danyael Rosales is a street preacher who thinks God does not care about anyone because of the death of his parents, Valerie Rosales and the angel Danyael from the previous film. He is then forced to face his destiny. As a Nephilim, he has some of the angels' abilities, such as regeneration, and can only be killed if his heart is removed. One night, a blind assassin shoots Danyael as he preaches before a crowd, but the assassin is driven off before he can take out Danyael's heart. As punishment for his failure, Zophael kills the assassin and goes after Danyael himself with an extendable weapon with a blade that can be turned into a three-pronged hook. However, Danyael is protected by Gabriel, a now-human fallen angel who killed Danyael's father and performed many misdeeds. After being defeated by Danyael's mother, Gabriel was turned into a human as punishment. Having spent years as a human, he now realizes how wrong he was in the past.
In 1806, Pittsburgh farmer Johnny Appleseed watches as pioneers depart out west and wishes he could follow. Johnny is inspired by an angel to abandon his farm, go west, and plant apple seeds everywhere he goes. The angel tells Johnny that he has all that he needs to go out West: a bag of seeds to plant, a Bible, and a pot that he can use for a hat. In his travels, Johnny befriends a skunk, and thereafter, all animals instinctively trust him. In the end, after walking hundreds of miles and planting apple trees all along the way, Johnny finally rests for the last time under a tree; his angel appears before him, and tells Johnny that it's time to go. Johnny gets up, scared at first upon realizing he's dead, but refuses to go to his final resting place, believing that his work is not done yet. However, the angel tells him that, where they're headed, they're low on apple trees, so Johnny picks up his seed bag and happily agrees to go with him.
When Eddie Everett was a rookie in 1992, he was one of the best pitchers of his time. He led the California Angels to the American League Championship Series, where they played the Boston Red Sox, and were one out away from making it to the World Series (this same situation occurred in real life, but in 1986, not 1992). When a rookie playing for the Red Sox hits a ground ball to Eddie, he bobbles it and is unable to get him out, while the runners he let on base score, losing a chance for the Angels to make it to the World Series. Ever since then, he had never been the same pitcher, or the same person.