Le convoi d'Ajax est attaqué par Deadpool. Il commence par massacrer les gardes à l'intérieur d'une voiture, avant de s'en prendre au reste du convoi. Après une longue escarmouche, où il est contraint de n'utiliser que les douze balles qu'il lui reste, Deadpool capture Ajax (de son vrai nom Francis, ce que Deadpool ne cesse de lui rappeler). Après l'intervention de Colossus et Negasonic venus empêcher Deadpool de causer plus de dégâts et le rallier à la cause des X-Men, Ajax parvient à s'échapper en retirant le sabre de son épaule. Il apprend par la même occasion la véritable identité de Deadpool : Wade Wilson.
Hazel Grace Lancaster (Shailene Woodley) is an intelligent and witty teenager living in Indianapolis, who has terminal thyroid cancer that has since spread to her lungs. Believing she is depressed, Hazel's mother Frannie (Laura Dern) urges her to attend a weekly cancer patient support group to help her make friends who are going through the same thing.
In 2154, Earth is overpopulated and polluted. Most of the earth's citizens live in poverty, on the edge of starvation, and with little technology and medical care. The rich and powerful live on Elysium — a gigantic, terraformed space habitat located in Earth's orbit. Elysium is technologically advanced; such technology includes Med-Bays: medical machines that can cure all diseases, reverse the aging process and regenerate new body parts. A long-running feud exists between the wealthy residents of Elysium and the citizens of Earth, who want Elysian technology to cure their medical ailments.
Blue-collar mechanic Carter Chambers (Freeman) and billionaire hospital magnate Edward Cole (Nicholson) meet for the first time in the hospital after both have been diagnosed with terminal lung cancer. Although Edward is reluctant to share a room with Carter, complaining that he "looks half-dead already", they become friends as they undergo their respective treatments.
Jackie and Luke Harrison (Susan Sarandon and Ed Harris) are a divorced New York couple that are struggling to help their children Anna (Jena Malone) and Ben (Liam Aiken) be happy with this sudden change of lifestyle. This is far from easy, as Luke, an attorney, is living with his new girlfriend, Isabel Kelly (Julia Roberts), an NYU alumna and a successful fashion photographer several years his junior. Isabel tries very hard to make Anna and Ben feel comfortable and happy with her, but Anna repeatedly rejects her overtures while Ben, who loves Isabel (not as much as his actual mother), adds extra complication with his mischievous nature. Isabel behaves with contempt tempered by caution around Jackie, believing she overcompensates for her divorce by spoiling her children.
Oliver Barrett IV comes from an American upper class east coast family and is heir to the Barrett fortune. He attends Harvard University, and is very active in ice hockey for the university. At the library, Oliver meets Jennifer "Jenny" Cavalleri, a quick-witted, working-class Radcliffe College student of classical music. She mocks him calling him "preppy" and "jock". Oliver finds a charm and truism in her comments. They quickly fall in love, despite their differences.
Aurora Greenway (Shirley MacLaine) and her daughter Emma (Debra Winger) are both searching for deep romantic love. Beginning with Emma's early childhood, Aurora reveals how difficult and caring she can be by nearly climbing into Emma's crib in order to make sure her daughter is breathing—only to be reassured when Emma starts crying (after being woken up). After the death of Aurora's husband and Emma's father Rudyard (A. Brooks), Aurora and Emma develop an extremely close love-hate mother/daughter relationship as Emma grows up.
Conceived by means of in vitro fertilization, Anna Fitzgerald (Abigail Breslin) was brought into the world as a savior sister at the informal suggestion of Kate's doctor, Dr. Chance (David Thornton) (a formal suggestion from the doctor would have been a violation of legal and medical ethics). As a genetic match for her older sister, Kate (Sofia Vassilieva), who suffers from acute promyelocytic leukemia, to donate compatible organs, blood and tissue in order to keep her sister alive. Her family members are introduced one by one, and each tells about how Kate's illness has affected them personally. When Kate turns 15, she goes into renal failure. Eleven-year-old Anna knows that she will be forced by her parents to donate one of her kidneys. She also realizes that she may not be able to live the life she will want to lead - she may be unable to cheerlead, play soccer, or be a mother. Anna tells her parents that she does not want any of this and proceeds to sue them for medical emancipation and the rights to her own body. Her domineering mother, Sara (Cameron Diaz), who leads an obsessive campaign to keep Kate alive, is indignant at Anna's decision when she receives the notice of court proceedings. Attorney Campbell Alexander (Alec Baldwin) agrees to work for Anna as her guardian ad litem, suing for partial termination of parental rights. It is later learned he agreed to take the case not for the notoriety, but because he suffers from epilepsy, and is genuinely sympathetic to her predicament.
Hilary O'Neil (Julia Roberts) is a pretty, outgoing yet cautious young woman who has had little luck in work or love. After recently parting ways with her boyfriend when she caught him cheating, Hilary finds herself living with her eccentric mother (Ellen Burstyn).
Nelson Moss meets Sara Deever, a woman very different from anyone he has met before. His ignorance leads to her failing her driving test. She beguiles him and continually asks him to spend a month with her on the promise that she will change his life for the better. On the first night of November, after Nelson is fired and dumped on the same day, she sleeps with him, and the next day Chaz, a close friend of Sara's, arrives and identifies Nelson as Sara's "November".
George Simmons (Adam Sandler) is a middle-aged former stand-up comedian turned movie star. Despite his millions he is sad and lonely and most of his recent film work is low-brow and dumb. He is diagnosed with acute myeloid leukemia and offered an experimental treatment that has only an eight-percent chance of therapeutic response. Believing he is about to die, he returns to his roots to do stand-up comedy.
Popular and rebellious teenager Landon Carter (Shane West) is threatened with expulsion from school after he and his friends leave evidence of underage drinking on the school grounds and seriously injure another student as the result of a prank gone wrong. The head of the school gives Landon the choice of being expelled or atoning for his actions by tutoring fellow students and participating in the school play. During these functions, Landon notices Jamie Sullivan (Mandy Moore), a girl he has known since kindergarten and who has attended many of the same classes as him, and who is also the local minister's daughter. Since he's one of the in-crowd, he has seldom paid any attention to Jamie, who wears modest dresses all the time and owns only one sweater. She makes no attempt to wear make-up or otherwise improve her looks or attract attention to herself.
Adam Lerner is a 27-year-old public radio journalist in Seattle with an artist girlfriend Rachael, of whom his best friend and co-worker Kyle disapproves; where Kyle is brash and outspoken, Adam is more introverted and mild-mannered.
Dr Jack McKee is a successful surgeon at a leading hospital. He and his wife have all the trappings of success, although Jack works such long hours that he rarely has time to see their son and has become somewhat emotionally dead to his wife. His "bedside manner" with his patients, in many cases seriously ill, is also quite lacking. The decorum in the operating theater is very casual, loud country and rock music, and the chatter between him and his partner, Dr. Murray Kaplan, not particularly professional. (When a patient with a chest scar mentions her husband is not close anymore, Jack responds that she should tell him that she is just like a "Playboy centerfold, because she has the staple marks to prove it.