After years of pursuing drug lord Cullen Crisp (Richard Tyson), Los Angeles Police Detective John Kimble (Schwarzenegger) has him on a murder charge after Crisp shot and killed an informant (Tom Kurlander) who has given him information regarding the whereabouts of his ex-wife, Rachel Myatt Crisp, and his son Cullen, Jr. However, the informant's girlfriend (Alix Koromzay) is unwilling to testify in court.
In 2005, bookish student Morton Schmidt (Jonah Hill) and popular underachieving jock Greg Jenko (Channing Tatum) miss their school prom. Seven years later, the two meet again at the Police Academy and become firm friends and partners on bicycle patrol. They catch a break when they arrest Domingo (DeRay Davis), the leader of a one-percenter motorcycle gang, but are forced to release him after they failed to read him his Miranda rights.
Tom Baker (Martin) is a football coach at a small rural college in Midland, Indiana, where he raised twelve children, and his wife, Kate (Hunt), has written about her story in a book and hopes to send it to her friend to publish it. At the film's beginning, Tom unexpectedly receives an offer from his old friend and football teammate, Shake McGuire (Jenkins), to coach at his alma mater in Evanston, Illinois. Tom accepts the offer, and he and Kate begin making their plans on moving to Evanston. All twelve children find out and demand the move be put to a vote, even though Tom says it would not have any power. Tom loses the vote, even after he and Kate join, but goes ahead with the move anyway, claiming there will be more money and that they will be a "happier and stronger family". However, the atmosphere at the Bakers' new house is tense, and the situation at school for the children is even worse, although their new neighbors' the Shenks seem allright, especially their first and only son, Dylan.
LouAnne (Michelle Pfeiffer), a discharged U.S. Marine, applies for a teaching job in High School, and is surprised and pleased to be offered the position with immediate effect. Showing up the next day to begin teaching, however, she finds herself confronted with a classroom of tough, sullen teenagers, all from lower-class and underprivileged backgrounds, involved in gang warfare and drug pushing, flatly refusing to engage with anything. They immediately coin the nickname "White Bread" for LouAnne, due to her race and apparent lack of authority, to which LouAnne responds by returning the next day in a leather jacket and teaching them karate. The students show some interest in such activities, but immediately revert to their former behavior when LouAnne tries to teach the curriculum.
Matt Murdock is a blind lawyer in New York City's Hell's Kitchen neighborhood, where he runs a firm with best friend Franklin "Foggy" Nelson. As a child, Matt was blinded by a toxic waste spill while walking home from school after discovering that his father, former boxer Jack "The Devil" Murdock, had become an enforcer for a local mobster. The accident enhanced Matt's other senses and gave him sonar to "see" via sonic vibrations. Matt trained himself in martial arts. Blaming himself for Matt's disability, Jack stopped being an enforcer, returned to boxing, and was killed after refusing to turn in a fixed fight for the mobster who had employed him earlier. After his Fathers death, Young Matthew promised to stop all crime that controlled Hell's Kitchen, New York as the vigilante crime-fighter "Daredevil".
Professor Philip Brainard (Robin Williams) of Medfield College is developing a new energy source, in an attempt to raise enough money to save the college from closure. His preoccupation with his research distracts him from his fiancée, the college president Sara Jean Reynolds (Marcia Gay Harden). He has missed two weddings because of that preoccupation, much to Sara's anger. On the day of the third attempted wedding, Philip is approached by his former partner Wilson Croft (Christopher McDonald), who has profited from ideas he has stolen from the chemist and now desires to steal Sara from Philip and make her his wife, which he declares directly to Philip. Before he can make it to the wedding, his latest experiment shows fast development, forcing him to miss another wedding. The resulting substance created from the experiment is a green goo that increases in speed as it bounces and proves to be difficult to control, wreaking havoc on the neighborhood before the professor finally manages to capture it. Weebo (voiced by Jodi Benson), Philip's hovering robot assistant, classifies the substance as "flying rubber", leading Philip to christen it as "Flubber".
Amélie Poulain was raised by eccentric parents who — erroneously believing that she had a heart defect — prevented her from meeting other children. She was home schooled by her mother. She developed an active imagination and fantasy life to cope with her loneliness. After her mother is killed in a freak accident, her father's withdrawal from society worsens. Amélie eventually decides to leave home and becomes a waitress at Café des 2 Moulins in Montmartre, which is staffed and frequented by a collection of eccentrics. Spurning romantic relationships after a few disappointing efforts, she finds contentment in simple pleasures and letting her imagination roam free.
In New York City's Central Park, people begin committing mass suicide. Initially believed to be caused by a bio-terrorist attack using an airborne neurotoxin, the behavior quickly spreads across the northeastern United States. Elliot Moore, a high school science teacher in Philadelphia, hears about the attacks and decides to go to Harrisburg by train with his wife, Alma. They are accompanied by his friend Julian and Julian's eight-year-old daughter Jess. Julian's wife is stuck in Philadelphia but is expected to meet them in Harrisburg. The train loses all radio contact en route and stops at a small town. They receive word that Philadelphia has been attacked by the toxin and Julian's wife was not able to get on the train to Harrisburg. Julian decides to go look for her, leaving his daughter with the Moores while he hitches a ride. However, the town has already been hit by the toxin. Succumbing to it, the driver and Julian both commit suicide.
John Smith (Alex Pettyfer) is an alien from the planet Lorien. He was sent to Earth as a child with eight others to escape the invading Mogadorians, who destroyed Lorien. Here, John is protected by a Cepan, or guardian, Henri (Timothy Olyphant). Together, they live in a beach-side bungalow in Florida.
When the film opens, a St. Bernard puppy and a large group of others are stolen from a pet store by two thieves, Harvey (Oliver Platt) and Vernon (Stanley Tucci). After meeting a dog during his escape from the thieves, the St. Bernard sneaks into the home of the Newton family. The workaholic father, George Newton (Charles Grodin), doesn't want the responsibility of owning a dog, but his wife, Alice (Bonnie Hunt), and their children, Ryce, Ted and Emily, convince him otherwise. While trying to name him, Emily (Sarah Rose Karr), plays a portion of Ludwig van Beethoven's Fifth Symphony and he barks along: thus they name him "Beethoven."
In 1953, Katherine Ann Watson (Julia Roberts), a 30-year-old graduate student in the department of Art History at Oakland State, takes a position teaching "History of Art" at Wellesley College, a conservative women's private liberal arts college in Massachusetts, because she wants to make a difference and influence the next generation of women. At her first class, Katherine discovers that the girls have already memorized the entire syllabus from the textbook, so she instead uses the classes to introduce them to Modern Art and encourages spirited classroom discussions about topics such as what makes good art and what the Mona Lisa's smile means. This brings her into conflict with the conservative college president (Marian Seldes), who warns Katherine to stick to the syllabus if she wants to keep her job. Katherine comes to know many of the students in her class well and seeks to inspire them to achieve more for themselves as intelligent women than the expected convention of marriage to eligible young men. Joan Brandwyn (Julia Stiles) dreams of being a lawyer and has enrolled as pre-law, so Katherine encourages her to apply to Yale Law School, where she is accepted; Katherine finds her liberal sensibilities affronted when Joan's fiancé Tommy (Topher Grace) comments Joan "will always have that", intimating his own expectations of what his wife should be. Joan eventually elopes with Tommy, and professes to Katherine she is very happy—she had decided that what she wants most is to be a wife and mother after graduation and asks Katherine to respect her choice.
Jesse "Jess" Aarons (Josh Hutcherson) is a twelve-year-old aspiring artist living with his financially struggling family in Lark Creek. He rides the bus to school with his little sister May Belle (Bailee Madison), where he avoids the school bully Janice Avery (Lauren Clinton). In class, Jess is teased by classmates Scott Hoager (Cameron Wakefield) and Gary Fulcher (Elliot Lawless), and meets new student Leslie Burke (AnnaSophia Robb). At recess, Jess enters a running event, for which he had been training at home. Leslie also enters and manages to beat all the boys, much to Jess' irritation. On the way home, Jess and Leslie learn that they are next-door neighbors.
Dewey Finn is a guitarist and member of the rock band No Vacancy. However, he is unanimously voted out of the band due to his onstage antics. Dewey shares an apartment with his friend Ned Schneebly, a former rocker now substitute teacher, and his bossy girlfriend Patty Di Marco, who threatens to kick him out unless he pays his overdue rent. One day, Dewey answers a phone call from Principal Rosaline Mullins of the prestigious Horace Green prep school, inquiring for Ned about a short-term position as a substitute. Realising the pay would be high, Dewey pretends he is Ned and is hired. Meeting the tightly wound Mullins, Dewey adopts the name “Mr. S” and spends his first day being lazy, much to the class’ confusion.
Daniel LaRusso (Ralph Macchio), a high school senior, moves with his mother Lucille (Randee Heller) from Newark, New Jersey to Reseda, a neighborhood in the Los Angeles, San Fernando Valley area. Their apartment's handyman is an eccentric but kind and humble Okinawan immigrant named Kesuke Miyagi (Noriyuki "Pat" Morita).
Sixteen-year-old homeschooled Cady Heron (Lindsay Lohan) and her zoologist parents (Ana Gasteyer and Neil Flynn) return to the United States after a 12-year research trip in Africa, settling in Evanston, Illinois. Cady attends a public school for the first time, meeting new classmates Janis (Lizzy Caplan) and Damien (Daniel Franzese). The two warn Cady to avoid the school's most exclusive clique, the Plastics, who are led by queen bee Regina George (Rachel McAdams). The Plastics take an interest in Cady, however, and start to invite her to sit with them at lunch. Seeing that Cady is slowly becoming one of The Plastics, Janis hatches a plan of revenge against Regina, using Cady as the infiltrator.