Alice (Milla Jovovich) wakes up disoriented in a mansion. She wanders through the halls, where she defeats several obstacles, including a laser beam obstacle (from the first film) and a giant blade that falls from the ceiling. However, she is eventually killed by a miniature machine gun. Her body is dumped into a pit filled with hundreds of Alice clones. The camera zooms out to show a shack camouflaging the facility's above-ground entrance - with the rest of the facility located underground, surrounded by a high fence and thousands of zombies.
Returning from a Hong Kong business trip, Beth Emhoff has a layover in Chicago to have sex with a former lover before returning to her family in suburban Minneapolis. She appears to have contracted a cold during her trip. Her six-year-old son from a previous marriage, Clark, also becomes symptomatic and is sent home from school. Beth's condition worsens and two days later she collapses with severe seizures. Her husband, Mitch, rushes her to the hospital, but she dies of an unknown cause.
30 days after the contamination of The Hive seen in Resident Evil (2002), the Umbrella Corporation unwisely sends in a research team to re-open the complex and investigate the incident, since no one survived except Alice and Matt Addison, and as Alice was experimented on, Matt was put into a mysterious "Nemesis Program". When the team reprograms and opens the sealed blast doors, they are slaughtered by the massive crowd of infected.
A group of vampires look for the hidden resting place of Drake, also known as Dracula—the genetic "father" of their species. They find him in a Syrian ziggurat tomb, although not before, in a moment of blood lust, he kills one of them. The vampires capitalize on Blade's reputation as a serial killer and frame him for the killing of a familiar. During the ensuing manhunt, the FBI locate Blade's latest hideout, and, during the siege, Abraham Whistler dies. With his mentor gone and surrounded by human authorities, Blade allows himself to be captured and arrested.
Dix ans après, Tallahassee, Columbus, Wichita et Little Rock font toujours équipe et luttent ensemble pour survivre face aux zombies, qui avec le temps ont évolué : parmi les zombies simples sont apparus les « Homer », en surpoids et simples d'esprit, les « Hawking », capables de stratégie, les « ninjas », rapides et silencieux, mais surtout les « T-800 », plus féroces et résistants aux balles. Le groupe trouve un temps refuge dans la Maison-Blanche. Mais des tensions apparaissent dans le groupe : Columbus et Wichita vivent leur petite vie de couple jusqu'à ce que Columbus demande la main de Wichita, et Tallahassee « couve » Little Rock comme un père, alors que cette dernière, devenue jeune adulte, a des envies d'ailleurs et d'être avec des gens de son âge. Une nuit, Wichita et Little Rock décident de partir à bord de la voiture blindée et surarmée de Tallahassee.
About eight years after a zombie apocalypse, R, a zombie, spends his days wandering around an airport which is now filled with hordes of his fellow undead, including his best friend M. R and M achieve rudimentary communication with grunts and moans and occasional near-words. As a zombie, R constantly craves human flesh, especially brains, as he is able to "feel alive" through the victims' memories he experiences when he eats them.
In 1202, an army led by the three vampire elders (Markus, Viktor, and Amelia) arrives at a Lycan-ravaged village. Viktor and Amelia capture their target: Markus' brother, William Corvinus, the first and most powerful werewolf. Despite Markus' defiance, Viktor orders that William be imprisoned in a secret location forever.
In the small town of Blithe Hollow, Massachusetts, Norman Babcock (Kodi Smit-McPhee) is an 11-year-old boy who speaks with the dead, including his late grandmother (Elaine Stritch) and various ghosts in town. Almost no one believes him and he is isolated emotionally from his family while being ridiculed by his peers. His friend, Neil Downe (Tucker Albrizzi), is an overweight boy who is bullied himself and finds in Norman a kindred spirit. During rehearsal of a school play commemorating the town's execution of a witch three centuries ago, Norman has a vision of the town's past in which he is pursued through the woods by townsfolk on a witch hunt. Afterward, the boys are confronted by his estranged and seemingly deranged uncle Mr. Prenderghast (John Goodman) who tells his nephew that he soon must take up his regular ritual to protect the town. Soon after this encounter, Prenderghast dies from a sudden stroke. During the official performance of the school play Norman has another vision, creating a public spectacle of himself which leads to his father (Jeff Garlin) grounding him. His mother (Leslie Mann) tells him that his father's stern manner is because he is afraid for him. The next day, Norman sees Prenderghast's spirit who tells him that the ritual must be performed with a certain book before sundown that day. Norman is at first reluctant to go because he is scared but his grandmother tells him it is all right to be scared as long as he does not let it change who he is. Norman sets off to retrieve the book from Prenderghast's house (having to take it from his corpse).
Underneath Raccoon City exists a genetic research facility called the Hive, owned by the Umbrella Corporation. A thief steals the genetically engineered T-virus and contaminates the Hive with it. In response, the facility's artificial intelligence, the Red Queen, seals the Hive and kills everyone inside.
Two months have passed since a mutated strain of mad cow disease mutated into "mad person disease" that became "mad zombie disease" which overran the entire United States population, turning American people into vicious zombies. Unaffected college student "Columbus" (Jesse Eisenberg) is making his way from his college dorm in Austin, Texas to Columbus, Ohio to see whether his parents are still alive. He encounters "Tallahassee" (Woody Harrelson), another survivor who is particularly violent in killing zombies. Though he does not appear to be sociable, Tallahassee reluctantly allows Columbus to travel with him. Tallahassee mentions he misses his "puppy" that was killed by zombies, as well as his affinity for Twinkies, which he actively tries to find. Survivors of the zombie epidemic have learned that it is best not to grow attached to other survivors, because they could die at any moment, so many have taken to using their city of origin as nicknames, i.e. "Columbus" is from Columbus, Ohio.
After finishing a long shift, nurse Ana returns to her suburban neighborhood and her husband, Luis. Caught up in a scheduled date night, they miss an emergency news bulletin. The next morning, a neighborhood girl enters their bedroom and kills Luis, who immediately reanimates as a zombie and attacks Ana. She flees in her car but crashes and passes out. Upon waking, Ana joins with Police Sergeant Kenneth Hall, electronics salesman Michael, petty criminal Andre and his pregnant wife, Luda. They break into a nearby mall and are attacked by a zombified security guard, who scratches Luda. They are also confronted by three living guards — C.J., Bart, and Terry — who make them surrender their weapons in exchange for refuge. They split into groups to secure the mall and then go to the roof, where they see another survivor, Andy, who is stranded alone in his gun store across the zombie-infested parking lot.
For generations, a secret war has been waged between vampires and Lycans, an ancient species of werewolf. Selene, a Death Dealer, a vampire specialized in assassinating Lycans, tracks two Lycans. Selene's motivation goes beyond duty; she also wants revenge because, 600 years ago when she was a child, Lycans slaughtered her family. The vampires believe they defeated the werewolves many centuries ago and killed their leader, Lucian, and that they must kill the surviving Lycans. Selene locates the Lycans' den and learns they have developed a new kind of bullet capable of killing the vampires.
The film tells the story of Lucian, the first werewolf born in human form and the first to be called a Lycan. Viktor, a vampire elder, raises the child, and envisions a race of Lycan slaves that could keep guard of the coven's fortress during the day and be used as laborers by the vampires at night. To this end, Viktor demands from the local human nobles a tribute of silver, with which to keep his slaves under control. As Lucian grows up, he and Viktor's daughter Sonja (Rhona Mitra) fall in love and begin a secretive intimate relationship in their adult years. Sonja is reckless and insubordinate, and one night Lucian escapes and rescues Sonja from his werewolf brethren. Viktor, despite acknowledging that Lucian saved his daughter, cannot forgive the escape and locks Lucian away.
In Villach in the 13th century, three women are accused of witchcraft by a priest. While one claims to be a witch through persuasion from the church, one doesn't deny it and curses the priest. He orders them hanged and drowned. That done, he urges the guards to pull them back up for a ritual to make sure the so-called witches never come back to life. The guards refuse, claiming they are dead enough. The priest returns late at night to perform the ritual. The third corpse takes on a demonic appearance and kills the priest.