After defeating Owen Shaw and his crew and securing amnesty for their past crimes, Dominic "Dom" Toretto, Brian O'Conner, and the rest of their team have returned to the United States to live normal lives again. Brian begins to accustom himself to life as a father, while Dom tries to help Letty Ortiz regain her memories. Meanwhile, Owen's older brother, Deckard Shaw, breaks into the secure hospital the comatose Owen is being held in and swears vengeance against Dom, before breaking into Luke Hobbs' DSS office to extract profiles of Dom's crew. After revealing his identity, Shaw engages Hobbs in a fight, and escapes when he detonates a bomb that severely injures Hobbs. Dom later learns from his sister Mia that she is pregnant again and convinces her to tell Brian. However, a bomb, disguised in a package sent from Tokyo, explodes and destroys the Toretto house just seconds after Han, a member of their team, is killed by Shaw in Tokyo. Dom later visits Hobbs in a hospital, where he learns that Shaw is a rogue special forces assassin seeking to avenge his brother. Dom then travels to Tokyo to claim Han's body, where he meets and races Sean Boswell, a friend of Han's, who gives him personal items found at Han's crash site.
Minions are small, yellow creatures who have existed since the beginning of time, evolving from single-celled organisms into beings who exist only to serve history's most villainous masters. They find great masters—including a T-Rex, a caveman, an Egyptian pharaoh, Dracula, and Napoleon,—but after accidentally killing nearly all of them with their incompetence, they decide to isolate themselves from the world and start a new life in Antarctica. By 1968, the lack of a master to serve drives them into depression, so Kevin, one fearless Minion, plans to find a new one for them by going back out into the world. Stuart—a bored, teenaged minion who is obsessed with guitars—joins him reluctantly, as does an over-enthusiastic Bob, whom Kevin only chooses because of no one else willing to volunteer.
Dominick "Dom" Cobb (Leonardo DiCaprio) and Arthur (Joseph Gordon-Levitt) are "extractors", people who perform corporate espionage using an experimental military technology to infiltrate the subconscious of their targets and extract information while experiencing shared dreaming. Their latest target is Japanese businessman Saito (Ken Watanabe). The extraction from Saito fails when sabotaged by a memory of Cobb's deceased wife Mal (Marion Cotillard). Saito reveals that he was actually auditioning the team to perform the difficult act of "inception": planting an idea in a person's subconscious.
Following their successful Rio heist, Dominic "Dom" Toretto and his professional criminal crew have fled around the world: Dom lives with Elena; his sister Mia lives with Brian O'Conner and their son, Jack; Gisele and Han live in Hong Kong; and Roman and Tej live in luxury.
When Dominic "Dom" Toretto is being transported to Lompoc Prison by bus, his sister Mia Toretto and friend Brian O'Conner lead an assault on the bus, causing it to crash and freeing Dom. While the authorities search for them, the trio escapes to Rio de Janeiro. Awaiting Dom's arrival, Mia and Brian join their friend Vince and other participants on a job to steal three cars from a train. Brian and Mia discover that agents from the U.S. Drug Enforcement Administration (DEA) are also on the train and that the cars are seized property. When Dom arrives with the rest of the participants, he realizes that one of them, Zizi, is only interested in stealing one car, a Ford GT40. Dom has Mia steal the car herself before he and Brian fight Zizi and his henchmen, during which Zizi kills the DEA agents assigned to the vehicles. Dom and Brian are captured and brought to crime lord Hernan Reyes, the owner of the cars and Zizi's boss. Reyes orders the pair be interrogated to discover the location of the car, but they manage to escape and retreat to their safehouse.
In 1989, scientist Hank Pym resigns from S.H.I.E.L.D. after discovering their attempt to replicate his Ant-Man shrinking technology. Believing the technology is dangerous, Pym vows to hide it as long as he lives. In the present day, Pym's estranged daughter, Hope van Dyne, and former protégé, Darren Cross, have forced him out of his own company. Cross is close to perfecting a shrinking suit of his own, the Yellowjacket, which horrifies Pym.
Several years after the events of the series, Jim Phelps (Jon Voight) and his team, the Impossible Mission Force, are assigned to retrieve the IMF non-official cover list from the American embassy in Prague. Their mission fails: Phelps is shot point blank, his wife Claire (Emmanuelle Beart) dies in a car bombing, and the rest of the team except agent Ethan Hunt (Tom Cruise) are eliminated by an unknown assassin. Meeting later with IMF director Eugene Kittridge (Henry Czerny), Hunt learns the job was a setup designed to lure out a mole within IMF, whom IMF believes to be in contact with an arms dealer known as "Max" as part of "Job 314." As Hunt is the only member left, Kittridge suspects him of being the mole, and Hunt flees.
Following release from prison, Daniel "Danny" Ocean (George Clooney) violates his parole by traveling to California to meet his partner-in-crime and friend Rusty Ryan (Brad Pitt) to propose a caper. The two go to Las Vegas to pitch the plan to wealthy friend and former casino owner Reuben Tishkoff (Elliott Gould). The plan consists of simultaneously robbing the Bellagio, The Mirage, and the MGM Grand casinos. Reuben's familiarity with casino security makes him very reluctant to get involved, but when he starts to think of it as a good way to get back at his rival, Terry Benedict (Andy García), who owns all three casinos, Reuben agrees to finance the operation. Because the casinos are required by the Nevada Gaming Commission to have enough cash on hand to cover all their patrons' bets, the three predict that, on the upcoming night of a highly anticipated boxing match, the Bellagio vault will contain more than $150,000,000.
In New York City, the Bonwit Teller department store is destroyed by a bomb during the morning commute. The New York City Police Department receive a call from a man calling himself "Simon", ordering them that suspended police officer Lt. John McClane be dropped in Harlem wearing a sandwich board that says "I hate niggers" and threatening to detonate another bomb if they don't comply. They collect McClane and follow Simon's instructions; McClane is saved from a potential attack by a group of young men by Zeus Carver, a nearby shop owner. McClane and Carver escape and return to headquarters, where Simon calls again and threatens to detonate more bombs if McClane and Carver do not follow his instructions.
Terry Benedict (Andy García) locates all eleven members of Danny Ocean's (George Clooney) gang, demanding they return the $160 million they stole from his casinos plus $38 million interest. Short by half, the group schemes to stage another heist in Europe to avoid problems with United States authorities. They are tipped off by an informant named Matsui (Robbie Coltrane) about the location of the first stock certificate ever. After a complex series of schemes they find the document has already been stolen by "The Night Fox", another master thief. Europol Detective Isabel Lahiri (Catherine Zeta-Jones) is called in to investigate the theft and realizes that her talking earlier about a particular burglary with Rusty (Brad Pitt) during their relationship, would have given Rusty the idea of how to solve the complication the gang would have come up against. Surprising the group at their accommodation, she warns them they cannot beat the Night Fox or his mentor, the mysterious master-thief "LeMarc", both of whom excel in practicing the "long-con". She has been hunting both for years.
In 1963, teen-aged Frank Abagnale (Leonardo DiCaprio) lives in New Rochelle, New York with his father Frank Abagnale, Sr. (Christopher Walken), and French mother Paula (Nathalie Baye). When Frank Sr. is denied a business loan at Chase Manhattan Bank due to unknown difficulties with the IRS, the family is forced to move from their large home to a small apartment. Paula carries on an affair with Jack (James Brolin), a friend of her husband. Meanwhile, Frank poses as a substitute teacher in his French class. Frank’s parents file for divorce, and Frank runs away. When he runs out of money, he begins relying on confidence scams to get by. Soon, Frank’s cons increase and he even impersonates an airline pilot. He forges Pan Am payroll checks and succeeds in stealing over $2.
Stanley Ipkiss is a shy and unlucky bank clerk working at the local Edge City bank. He is frequently picked on by everyone around him like the Bank President's son Mr. Dickey, his ruthless landlady Mrs. Peenman, and the mechanics Irv and Burt Ripley who ripped him off. The only exception of this is his Jack Russell Terrier Milo and his co-worker and best friend Charlie Schumaker. Meanwhile, gangster Dorian Tyrell operates a nightclub called the Coco Bongo while plotting to overthrow his boss Niko. One day, Tyrell sends his singer girlfriend Tina Carlyle into Stanley's bank to record its layout, in preparation to rob the bank.
Benjamin Franklin Gates (Nicolas Cage) is an American historian, amateur cryptologist, and the youngest descendant of a long line of treasure hunters. While his father Patrick Henry Gates (Jon Voight) discourages him from following in the family line, Ben is driven on by a story told by his grandfather, John Adams Gates (Christopher Plummer). According to John, a clue - the phrase "The secret lies with Charlotte" - was entrusted to the family by Charles Carroll of Carrollton in 1832, and would lead to the fabled "national treasure", a wealth of artifacts dating from Ancient Egypt and secretly hidden by the Founding Fathers and the Freemasons during the American Revolutionary War.
While scavenging for food, RJ the raccoon enters the cave of Vincent the bear who has a large wagon full of human food taken from a nearby rest stop. RJ accidentally wakes Vincent from his hibernation, and in a race to escape, causes the stash to roll out onto the nearby highway and get run over. To avoid being eaten himself, RJ promises Vincent that he will completely replace the stash within the week.