Nutty Professor II: The Klumps is a 2000 American romantic comic science fiction film directed by Peter Segal. It is a sequel to the 1996 film The Nutty Professor and stars Eddie Murphy. As in the original film, Murphy plays not only the inept but brilliant scientist, Sherman Klump, but also (wearing different, but equally elaborate makeup) most of Sherman's family. In contrast to the previous film, subplots which are centered on his family (mainly his parents) occupy a substantial part of the film.
Like the first film, the sequel's theme song is "Macho Man" by The Village People, which this time is played during the end credits.
After finding success with a DNA restructuring formula in the first film, Sherman Klump has created another formula which enables those who take it to find the Fountain of Youth. He has also met and fallen in love with a colleague, Denise Gaines, who has developed a method to isolate genetic material and later becomes his fiancée. Together, their work has enabled Wellman College to receive a $150 million award from a pharmaceutical firm to the excitement of Dean Richmond. Despite his good fortune, Sherman has a major problem: the personality of his vanquished alter ego, Buddy Love, is still ingrained inside him and causes him to act out in the same crass manner Buddy does.