A seemingly innocuous and respectable elderly lady is knocked down and critically injured by a bus on a London street. When the police search her handbag to find out her identity, they are astonished to discover a series of top secret military blueprints. The secret service are alerted and arrive at the hospital to question her, but she laughs in their faces before quietly dying.
Two unemployed brothers, Bob and Doug McKenzie (Rick Moranis and Dave Thomas), place a live mouse in a beer bottle in an attempt to blackmail the local beer store into giving them free Elsinore beer, but are told to take up the matter at the Elsinore brewery instead. After presenting the mouse to management at the brewery, the brothers are given jobs on the bottling line inspecting the bottles for mice.
The film explores the lives of three male friends and three female friends over the course of one year. Judy has an affair with her married boss. Sally is a party girl open to all experiences. Alice is morally strict but feels stuck.
Peter Gaulke is the host of an unsuccessful nature program called Strange Wilderness. When the show is threatened with cancellation, he goes in search of the elusive bigfoot in order to restore ratings.
Jimmy King, un agent de change de New York, se marie avec Nadia, une réfugiée russe, qui se fait passer pour une princesse, malgré les avertissements de son ami Warren. Bientôt, Jimmy se retrouve à être le soutien de toute la famille de Nadia. Le père de Nadia, le Général Kourajine, ne rêve lui que qu'une contre-révolution pour lutter contre les Bolcheviks. Pour se débarrasser de sa belle-famille, Jimmy cherche à exploiter leurs divers talents et ils trouvent finalement des sources de revenus qui leur donnent une indépendance. Après avoir évincé un ancien prétendant de Nadia, Jimmy est enfin reconnu comme le chef de famille.
The film is a three-act story about self-identified "hipster" Willie (John Lurie), who lives in New York City, and his interactions with the two other main characters, Eva (Eszter Balint) and Eddie (Richard Edson).