Following release from prison, Daniel "Danny" Ocean (George Clooney) violates his parole by traveling to California to meet his partner-in-crime and friend Rusty Ryan (Brad Pitt) to propose a caper. The two go to Las Vegas to pitch the plan to wealthy friend and former casino owner Reuben Tishkoff (Elliott Gould). The plan consists of simultaneously robbing the Bellagio, The Mirage, and the MGM Grand casinos. Reuben's familiarity with casino security makes him very reluctant to get involved, but when he starts to think of it as a good way to get back at his rival, Terry Benedict (Andy García), who owns all three casinos, Reuben agrees to finance the operation. Because the casinos are required by the Nevada Gaming Commission to have enough cash on hand to cover all their patrons' bets, the three predict that, on the upcoming night of a highly anticipated boxing match, the Bellagio vault will contain more than $150,000,000.
Terry Benedict (Andy García) locates all eleven members of Danny Ocean's (George Clooney) gang, demanding they return the $160 million they stole from his casinos plus $38 million interest. Short by half, the group schemes to stage another heist in Europe to avoid problems with United States authorities. They are tipped off by an informant named Matsui (Robbie Coltrane) about the location of the first stock certificate ever. After a complex series of schemes they find the document has already been stolen by "The Night Fox", another master thief. Europol Detective Isabel Lahiri (Catherine Zeta-Jones) is called in to investigate the theft and realizes that her talking earlier about a particular burglary with Rusty (Brad Pitt) during their relationship, would have given Rusty the idea of how to solve the complication the gang would have come up against. Surprising the group at their accommodation, she warns them they cannot beat the Night Fox or his mentor, the mysterious master-thief "LeMarc", both of whom excel in practicing the "long-con". She has been hunting both for years.
Four days after the events of the first film, detective James Carter is on vacation in Hong Kong, visiting his friend, Hong Kong Police Force Chief Inspector Lee, as he was sent along with Lee in saving the life of the Chinese counsel's daughter in Los Angeles. The fun is put on hold when a bomb explodes at the United States Consulate General, killing two undercover U.S. custom agents inside. Inspector Lee is assigned to the case, which becomes personal when it is discovered that it somehow involves Ricky Tan, his late police officer father's former partner. Tan, who was suspected of having a role in Lee's father's death - though the connection was never proven - is now a leader of the Triads. This, however, causes a rift between Lee and Carter, the later who simply wants to enjoy his vacation and not get into any danger.
L.A.P.D. Sergeants Martin Riggs (Gibson) and Roger Murtaugh (Glover) arrive at an evacuated building believed to have a bomb in it. Against orders, they go inside to investigate the bomb. Riggs decides to deactivate the bomb himself instead of waiting for the Bomb Squad to arrive. Unfortunately, he causes the bomb to detonate and the whole building to collapse. This causes them to be demoted to uniform duties, which upsets Murtaugh because he only has seven days until retirement. While on street patrol, the two thwart a robbery using a duplicate armored car, although they only manage to catch one of the two would-be thieves. During the arrest, it is discovered the criminals were armed with a new type of armor-piercing bullet, informally referred to as "cop killers". For their efforts in stopping the raid, Riggs and Murtaugh are reinstated as Detective Sergeants by their superior, Captain Murphy (Kahan). Murphy introduces internal affairs Sergeant Lorna Cole (Russo) to the two detectives and informs them that the suspect they have in custody from the raid is a known associate of former L.A.P.D. Lieutenant and suspected arms dealer: Jack Travis (Wilson).
Axel Foley is a young, reckless Detroit police detective. His latest unauthorized sting operation goes sour when two uniformed officers intervene, resulting in a high-speed chase through the city which causes widespread damage. This earns him the anger of his boss, Inspector Douglas Todd, who promises to fire Foley if another such incident happens again.
Beverly Hills Police Captain Andrew Bogomil, Detective Billy Rosewood, and Sergeant John Taggart are trying to figure out who is behind the "Alphabet Crimes," a series of mostly high end store robberies distinguished by their monogrammed envelopes with an alphabetical sequence the assailants leave behind. Complicating matters is the new "political" state of the Beverly Hills Police Department, headed by incompetent and verbally abusive new police chief Harold Lutz, who is doing everything he can to stay on Mayor Ted Egan's good side. Unimpressed when Rosewood calls the FBI to help solve the case, Lutz holds Bogomil responsible as commanding officer and suspends him, despite Bogomil's efforts to convince him that Rosewood was only following a hunch. Lutz also punishes Taggart and Rosewood by placing them on traffic duty. On the way home, Bogomil is shot and injured by Karla Fry, the chief hench-woman of Maxwell Dent, who secretly is the mastermind behind the Alphabet Crimes. Finding out about the shooting by a news report, Axel Foley abandons his current undercover duties and immediately flies out to Beverly Hills to help find out who shot Bogomil. Taggart and Rosewood agree to assist Foley because of Lutz's attempts to find an excuse to get them fired.
Debbie, la sœur de Danny Ocean, veut dérober un collier très convoité, lors du Met Gala au Metropolitan Museum of Art de New York. Elle souhaite par la même occasion se venger de son ex-petit-ami. Pour cela, elle forme une équipe constituée de sept autres « collègues » voleuses.
Lorna Cole (Rene Russo) is pregnant with LAPD sergeant Martin Riggs' baby; they are not married, but both are thinking about it. Police sergeant Roger Murtaugh's daughter Rianne (Tracie Wolfe), is also pregnant, and Riggs later learns from Lorna that Rianne has secretly married Lee Butters (Chris Rock), a young detective who works at the same station as Murtaugh and Riggs – secretly because Roger had made it clear that he does not want his daughter to marry a police officer. Due to the many disasters caused by both sergeants while on duty, the police department has lost its insurance carrier, and cannot get a new one while they're still out on the streets. Because firing them is not an option, the Chief uses a special privilege and they get temporarily promoted to captains, given that there aren't any lieutenant spots available.
Eight years after the events of the first film, Miami Police Department (MPD) narcotics division detectives Marcus Burnett and Mike Lowrey are investigating the flow of highly-potent ecstasy into the city. Their surveillance of boats coming in from Cuba leads them to a Ku Klux Klan meeting and drug drop in a swamp docks outside Miami. The subsequent raid on the Klan members proves to be a disaster; malfunctioning radios delay back-up, causing a firefight when Mike accidentally shoots Marcus in the buttocks, while the Klan members are revealed to be mere small-time buyers and not the distributors of the ecstasy. The incident leaves Marcus to further question if he still wants to partner with Mike, while Mike fears that Marcus may discover his new relationship with Marcus' sister, Syd.
L.A.P.D. Detective Carter is directing traffic. Concurrently, Chinese Ambassador Han addresses the importance of fighting the Triads at the World Criminal Court, announcing that he may know the whereabouts of Shy Shen, a semi-mythical individual of great importance to the Chinese mob. Before announcing, an assassin shoots Han in the shoulder, disrupting the conference. Chief Inspector Lee pursues the shooter and corners him, discovering that the assassin is his childhood Japanese friend Kenji. When Lee hesitates to shoot Kenji, he makes his escape when Carter (having heard what's happening over the police radio) arrives and tries to intervene.
On the last day of British rule in Hong Kong, Detective Inspector Lee of the Hong Kong Police Force leads a raid at a shipping bar wharf, hoping to arrest the mysterious crime lord Juntao. He finds only Sang, Juntao's right-hand man, who manages to escape. However, Lee successfully recovers numerous Chinese cultural treasures stolen by Juntao, which he presents as a farewell victory to his departing superiors: Chinese Consul Solon Han and British Commander Thomas Griffin.
One year after the events of Lethal Weapon, LAPD sergeants Martin Riggs and Roger Murtaugh are pursuing unidentified suspects transporting an illegal shipment of gold krugerrands. The Afrikaner apartheid government of South Africa subsequently orders local consul-general Arjen Rudd (Joss Ackland) and security agent Pieter Vorstedt (Derrick O'Connor) to warn both detectives off the investigation; they are reassigned to protecting an obnoxious federal witness, Leo Getz (Joe Pesci), after an attack on Murtaugh's home.
In 2005, bookish student Morton Schmidt (Jonah Hill) and popular underachieving jock Greg Jenko (Channing Tatum) miss their school prom. Seven years later, the two meet again at the Police Academy and become firm friends and partners on bicycle patrol. They catch a break when they arrest Domingo (DeRay Davis), the leader of a one-percenter motorcycle gang, but are forced to release him after they failed to read him his Miranda rights.
Two years following their success in the 21 Jump Street program, Schmidt (Jonah Hill) and Jenko (Channing Tatum) are back on the streets chasing narcotics. However, after failing in the pursuit of a group of drug dealers led by Ghost (Peter Stormare), Deputy Chief Hardy (Nick Offerman) puts the duo back on the program to work for Captain Dickson (Ice Cube) – now located across the street at 22 Jump Street. Their assignment is to go undercover as college students and locate the supplier of a drug known as "WHYPHY" (Work Hard, Yes, Play Hard, Yes) that killed a student photographed buying it on campus.