In 2012, an alien criminal, Boris the Animal, a Boglodite, escapes from a maximum-security prison on the moon and arrives on Earth, bent on taking revenge on Agent K, who shot off his left arm and captured him in 1969. He confronts K, who is with his partner Agent J, telling him he is "already dead". J then discovers that K was responsible not only for capturing Boris, but for deploying the "ArcNet", a shield that prevented the Boglodites from conquering Earth and caused their extinction.
Agent K and his partner Agent D intercept a truck smuggling illegal immigrants into the United States. Inside they discover an alien disguised as a human. When he runs, they shoot him and use neuralyzers to wipe the memories of the border patrol witnesses. D decides to retire and asks K to wipe his memory too. In upstate New York, an alien crash-lands and kills an abusive farmer named Edgar to use his skin as a disguise.
Gru, a supervillain, has his pride injured when an unknown supervillain steals the Great Pyramid of Giza, an action that is described by his colleague Dr. Nefario as "making all other villains look lame." Gru decides to do better, with the assistance of Dr. Nefario, by shrinking and stealing the Moon, an idea based on his childhood dream of being an astronaut, which was always disparaged by his mother Marlena. The plan is expensive and Gru seeks a loan from the Bank of Evil, where the president Mr. Perkins is impressed by the plan, but will only provide the money if Gru can obtain the necessary shrink ray first.
In 2805, Earth is long-abandoned and covered in heaps of garbage leftover from decades of mass consumerism, facilitated by the megacorporation Buy 'n' Large (BnL). Seven hundred years earlier, BnL evacuated Earth's population in fully automated starliners, leaving behind WALL-E trash compactor robots to clean the planet for humanity's eventual return, however the plan failed and all the bots were shut off. Only one WALL-E robot remains active, and has developed sentience after so many years of life-experience. He manages to remain active by repairing himself using parts from other inactive units.
April O'Neil (Megan Fox), a reporter for Channel 6 Eyewitness News in New York City, investigates a crime wave by criminals called the Foot Clan. At a dock at night, she sees the Foot raiding cargo containers. After an unseen vigilante attacks the thieves, April notices a symbol left behind. April's supervisor Bernadette Thompson (Whoopi Goldberg) and her coworkers are oblivious to her story. Later while covering a charity event thrown by Sacks Industries, April expresses gratitude to the company's CEO Eric Sacks (William Fichtner), who was her late father's (Paul Fitzgerald) lab partner.
Five years after Agent K's retirement, Agent J (Will Smith) is now a top operative for the MIB, the New York City-based agency that secretly monitors and regulates extraterrestrials' activity on Earth. J has no permanent partner since K resigned and Agent L returned to work in a morgue. Subsequent partners have not lived up to J's standards, so he neuralyzes them back to civilian status.
On the day of her wedding to news weatherman Derek Dietl, Susan Murphy is struck by a meteorite and its energy causes her to suddenly grow over fifty feet in height during the ceremony. She is tranquilized and awakens in a top secret government facility that houses monsters without human knowledge. She meets the warden W.R. Monger, and fellow inmates: Dr. Cockroach P.H.D., a mad scientist who became half cockroach after an experiment; B.O.B. (Benzoate Ostylezene Bicarbonate), a brainless, living mass of goo as a result of a food flavoring mutation; Insectosaurus, a mutated bug standing at over 300 feet in height, and The Missing Link, a prehistoric fish man who was thawed from deep ice; and Susan herself has been renamed to Ginormica. Meanwhile, in deep space, an alien named Gallaxhar is alerted to the presence of quantonium; a powerful energy source on Earth, and he sends a probe to retrieve it. After the probe crash lands on Earth, the president attempts to make first contact with it by playing a keyboard version of Axel F, but it begins to rampage toward San Francisco.
In the small town of Oakey Oaks, Chicken Little rings the school bell and warns everyone to run for their lives, allowing the whole town into a frenzied panic with much damage ensuing. Eventually, the Head of the Fire Department calms down enough to ask him what's going on and Little explains that a piece of the sky shaped like a stop sign had fallen on his head when he was sitting under the big oak tree in the town square; however, he is unable to find it. His father, Buck Cluck, assumes that this "piece of sky" was just an acorn that had fallen off the tree and had hit him on the head, making Little the laughing stock of the town.
The film revolves around a special team of trained secret agent animals, equipped with advanced tools that allows the mammalian members to talk to humans. The primary field team consists of guinea pigs Darwin (team leader), Juarez (martial arts), and Blaster (weapons/transportation), star-nosed mole Speckles (cyber intelligence) and fly Mooch (reconnaissance). The unit's leader Ben, orders an unauthorised infiltration of the residence of home electronics and appliances magnate, Leonard Saber, the owner of Saberling Technology, who has been under FBI investigation. The team is able to retrieve sensitive information about a sinister scheme that is set to occur in 48 hours. However, when Ben's superior arrives for his evaluation, his astonishment at the team's capabilities and technology is overcome by his indignation at Ben's unauthorized mission and the fact that the downloaded intelligence appears to be useless information about Saber's coffee makers. As a result, the government agent orders the unit shut down, the equipment seized and the animals to be used as experimental subjects to be killed. With the help of their human compatriots, Darwin, Juarez, Blaster, Mooch and Speckles escape with hopes of stopping Saber's scheme, but find themselves in a pet carrying case bound for a pet shop.
Dr. Jumba Jookiba is arrested and put on trial by the Galactic Federation for "illegal genetic experimentation", as evidenced by his Experiment 626, a living creature which is capable of creating untold chaos. Jumba is imprisoned while Experiment 626 is supposed to be exiled on a desert asteroid. 626 manages to escape in a spaceship and activates the hyperdrive, causing its guidance systems to malfunction and randomly set a course for Earth. The Grand Councilwoman dispatches Jumba and Agent Pleakley, the Council's Earth expert, to the planet to have 626 captured discreetly. 626 lands on the Hawaiian island of Kauaʻi, but is knocked unconscious by a passing truck and taken to an animal shelter.
Truman Burbank is the unsuspecting star of The Truman Show, a reality television program in which his entire life, since before birth, is filmed by thousands of hidden cameras, 24 hours a day, 7 days a week, and is broadcast live around the world. The show's creator and executive producer Christof is able to capture Truman's real emotion and human behavior when put in certain situations. Truman's coastal hometown of Seahaven is a giant set built under a giant arcological dome in the Los Angeles area. Truman's family and friends are all played by actors, allowing Christof to control every aspect of Truman's life.
In Rivet Town, Herb Copperbottom, a dishwasher at Gunk's Greasy Spoon diner, races through the streets, elated that he is going to be a father. He and his wife, Lydia, after 12 hours of "labor", construct the baby. He is named Rodney, and he becomes a young inventor who dreams of making the world a better place. Rodney idolizes Bigweld, a master inventor and owner of Bigweld Industries. During Rodney's adolescence, he invents a gadget, "Wonderbot", intended to help his father clean the dishes at the restaurant. When Herb's supervisor unexpectedly confronts them, Wonderbot breaks dishes, causing Herb to be put in debt and Rodney to be dismissed. Rodney takes his invention to Robot City to see Bigweld and get a job as an inventor at Bigweld Industries, so that he can help his father pay back his supervisor. His father encourages him and confides that he has always regretted not pursuing his dream of becoming a musician. Rodney arrives in Robot City and meets Fender, a ramshackle robot who takes souvenir photos and sells maps to the stars' homes. After a spectacular but harrowing ride on the crosstown express, Rodney arrives at the gate of Bigweld Industries.
In 1993, professional basketball player Michael Jordan announces his retirement from the sport to follow his late father’s career as a baseball player. However, it becomes evident that he is not as skilled in baseball as he was in basketball. Jordan is assigned a publicist, the bumbling Stan Podolak, to make his new career less bumpy. Elsewhere, in outer space, an intergalactic amusement park called Moron Mountain faces dwindling popularity, so its owner, Mr. Swackhammer, sends his diminutive minions, the Nerdlucks, to capture the Looney Tunes as new entertainment. The Looney Tunes live in an animated world hidden in the centre of the Earth, but are unable to listen to the Nerdlucks’ threats and challenge them to a game of basketball to try to win back their freedom.
Eccentric scientist and inventor Wayne Szalinski lives in his suburban home attempting to perfect a ray gun capable of shrinking objects, but the apples he uses as test objects instead blow up. After an argument between Wayne and his wife Diane, she spent the night with her mother and is currently at work, worrying her teenaged daughter Amy, and their son Nick, who has inherited his father's inventive ingenuity and intelligence. Next door neighbors; the Thompsons, are getting ready for a fishing trip, but Russ' oldest son Little Russ is less than enthusiastic, as he and his father's interests often clash, resulting in his feeling belittled, and he is more interested in meeting Amy than spending the weekend camping. Younger son Ron, however, is enthusiastic, though his relationship with Russ Sr. is strained when he inadvertently sets off a booby trap in the yard.