Dix ans après, Tallahassee, Columbus, Wichita et Little Rock font toujours équipe et luttent ensemble pour survivre face aux zombies, qui avec le temps ont évolué : parmi les zombies simples sont apparus les « Homer », en surpoids et simples d'esprit, les « Hawking », capables de stratégie, les « ninjas », rapides et silencieux, mais surtout les « T-800 », plus féroces et résistants aux balles. Le groupe trouve un temps refuge dans la Maison-Blanche. Mais des tensions apparaissent dans le groupe : Columbus et Wichita vivent leur petite vie de couple jusqu'à ce que Columbus demande la main de Wichita, et Tallahassee « couve » Little Rock comme un père, alors que cette dernière, devenue jeune adulte, a des envies d'ailleurs et d'être avec des gens de son âge. Une nuit, Wichita et Little Rock décident de partir à bord de la voiture blindée et surarmée de Tallahassee.
About eight years after a zombie apocalypse, R, a zombie, spends his days wandering around an airport which is now filled with hordes of his fellow undead, including his best friend M. R and M achieve rudimentary communication with grunts and moans and occasional near-words. As a zombie, R constantly craves human flesh, especially brains, as he is able to "feel alive" through the victims' memories he experiences when he eats them.
The film picks up immediately after the end of the last film, with Marybeth Dunston (Danielle Harris) blowing off the head of Victor Crowley (Kane Hodder) with a shotgun. She walks away and comes across the bodies of Vernon and John, where she hears Crowley in the woods. Marybeth starts up the chainsaw, but is grabbed by Victor. Marybeth kicks him, and he falls backwards onto the chainsaw, cutting him down the middle. She grabs a shotgun from one of the men and shoots Victor's head, and walks back into the city. She walks into the Jefferson Parish Police Department, immediately having guns drawn on her. Upon discovery of the twenty to thirty bodies at Honey Island Swamp, she is placed as the prime suspect in the murders by Sheriff Fowler (Zach Galligan), even after telling him numerous times about the events of the last two films. The Sheriff heads out to the swamp with the paramedics and fire department, leaving Deputy Winslow (Robert Diago DoQui) in charge of the station until he gets back.
A criminologist narrates the tale of the newly engaged couple Brad Majors and Janet Weiss who find themselves lost and with a flat tire on a cold and rainy late November evening. Seeking a telephone, the couple walk to a nearby castle where they discover a group of strange and outlandish people who are holding an Annual Transylvanian Convention. They are soon swept into the world of Dr. Frank N. Furter, a self-proclaimed "sweet transvestite from Transsexual, Transylvania". The ensemble of convention attendees also includes servants Riff Raff, his sister Magenta, and a groupie named Columbia.
Two months have passed since a mutated strain of mad cow disease mutated into "mad person disease" that became "mad zombie disease" which overran the entire United States population, turning American people into vicious zombies. Unaffected college student "Columbus" (Jesse Eisenberg) is making his way from his college dorm in Austin, Texas to Columbus, Ohio to see whether his parents are still alive. He encounters "Tallahassee" (Woody Harrelson), another survivor who is particularly violent in killing zombies. Though he does not appear to be sociable, Tallahassee reluctantly allows Columbus to travel with him. Tallahassee mentions he misses his "puppy" that was killed by zombies, as well as his affinity for Twinkies, which he actively tries to find. Survivors of the zombie epidemic have learned that it is best not to grow attached to other survivors, because they could die at any moment, so many have taken to using their city of origin as nicknames, i.e. "Columbus" is from Columbus, Ohio.
Rebecca (Olivia DeJonge) and Tyler (Ed Oxenbould) prepare for a week-long stay with their grandparents, John (Peter McRobbie) and Doris (Deanna Dunagan), while their mother, Paula (Kathryn Hahn), goes on a cruise with her new boyfriend. The two kids, who have never met their grandparents, intend to film a documentary about their visit. Paula has not seen her parents in 15 years, after she eloped with her high-school teacher, Robert, who has since left her. She tells Rebecca little about the disagreement she had with her parents, suggesting that Rebecca ask them for more details.
On the 15th anniversary of the Woodsboro Massacre, high school students Jenny Randall and Marnie Cooper are attacked and brutally murdered in their home by a new Ghostface.
In 1969 in Pasadena, California, a couple seeks the aid of the medium Shaun San Dena (Flor de Maria Chahua) saying their son (Shiloh Selassie) has been hearing evil spirits' voices after stealing a silver necklace from gypsies. San Dena aids the family by carrying out a seance, but they are attacked by an unseen force that pulls the boy into Hell. The medium says she will encounter the force again one day.
Dr. Frederick Frankenstein (Gene Wilder) is a physician lecturer at an American medical school and engaged to the tightly wound socialite Elizabeth (Madeline Kahn). He becomes exasperated when anyone brings up the subject of his grandfather, the infamous mad scientist. To disassociate himself from his forebear, Frederick insists that his surname is pronounced "Fronkensteen."
Fisherman Matt Boyd (Richard Dreyfuss) is fishing in Lake Victoria when a small earthquake hits, splitting the lake floor and causing a whirlpool. Boyd falls in, and is ripped apart by a shoal of piranhas that emerge from the chasm.
Charlie Sheen and Lindsay Lohan get together to make a sex tape with over 20 cameras beside Sheen's bed. The time-lapsed tape fast forwards through the two doing all sorts of bedroom antics, including gymnastics, riding a horse, and having clowns jump in under the sheets. Sheen is pulled into the air by a paranormal force and thrown against walls, shelves, and doors until he lands on the bed again. Lohan is frightened so she decides to go home when she flies into the air as well; she becomes possessed and throws him into the camera and kills him. The text explains that Sheen's body was found that day but he didn't stop partying until days later, and that his three kids were found missing, Lohan was arrested, again, and a reward was put out for the missing children.
Barbara and Adam Maitland decide to spend their vacation decorating their idyllic Connecticut country home. As the two are driving home from a trip to town, Barbara swerves to avoid a dog and the car plunges into a river. After they return home, she and Adam notice that they now lack reflections and they discover a Handbook for the Recently Deceased.
In the underground Facility, senior technicians Gary Sitterson and Steve Hadley discuss plans for a mysterious ritual. A similar operation undertaken by their counterparts in Stockholm has just ended in failure.
In 1974, a woman makes a wax sculpture as one of her sons eats breakfast. Her husband enters with another son. After being strapped and taped into his chair, he scratches his mother's hand. Then she slaps the child across the face.
19 septembre 2017. Le lendemain de son anniversaire, tout est enfin rentré dans l'ordre pour Theresa « Tree » Gelbman qui se réveille au côté du garçon qu'elle aime, Carter Davis. Néanmoins, le colocataire de ce dernier, Ryan Phan, débarque dans la chambre pour leur dire qu'il vient de se réveiller au même endroit où il était ce matin, après s'être fait tué par un tueur au masque de bébé de la mascotte de l'université.