In 1982, a shady transaction is occurring between an East German scientist, Dr. Krause, and a group of Americans. It is revealed that MM88 is a deadly virus, created accidentally by an American geneticist, that amplifies the potency of any other virus or bacterium it comes into contact with. The Americans recover the MM88, which was stolen from a lab in the US the year before, but the virus is released, creating a pandemic initially known as the "Italian Flu".
The film opens to a shot of an abandoned office, where the main character (Pierre Jolivet), who is only identified as 'The Man' in the end credits, is having intercourse with a sex doll. The Man is then seen attempting to salvage parts from abandoned vehicles, but returns to his dwelling empty handed, where he works on building a makeshift aircraft. The Man ventures outside the office building he lives in, which is surrounded by a desert wasteland. A group of men are shown surviving in the wasteland. They hold a man, 'The Dwarf' (Maurice Lamy), captive, and force him to retrieve water for them. The Man, who has been observing the survivors, makes his way to their camp, stabs their leader, 'The Captain' (Fritz Wepper) and retrieves a car battery. Survivors pursue The Man, though he is able to escape in his now completed aircraft.
In 1940/50, world peace is threatened when the "United States of Europe" comes into conflict with the "Empire of the Atlantic States". The former comprises Europe, India, the Middle East, Canada, Africa and Australasia. The latter is a combination of the United States and South America.
Ikigami takes place in a dystopian society where the government has implemented the "Prosperity Law". This law dictates 1 in 1000 random citizens ages 18~24 will die for the state in a mandatory lottery. Death occurs at a preset date and time, which is when an injected nano-capsule, received at an early age, explodes. The law is meant to create appreciation for life by instilling fear in order make people live the best possible lives.
Dans un futur proche, un jeu télévisé intitulé Le Prix du danger fait fureur. Les règles sont simples : un homme doit parvenir à rejoindre un endroit secret, en échappant à cinq traqueurs chargés de le tuer. Si le candidat gagne, il se voit attribuer la somme de 1 million de dollars, ce qui n'est encore jamais arrivé... Le tout se déroule en pleine ville, filmé et retransmis en direct sur la chaîne de télévision CTV. François Jacquemard, un jeune chômeur, veut sortir de son quotidien morose et malgré les réticences de sa compagne, décide de participer au jeu.
Mai 2025 : Marine Le Pen, Présidente de la République, démissionne. Étienne, cadre de la climatisation nationale, se fait licencier et, n’osant pas affronter cette réalité, erre de bar en bar. Il rencontre alors « Montaigne », agrégé de philo, qui mène une vie de bohème assumée. Étienne devient alors « La Boétie » et ils ne se quittent plus. Une troupe de marginaux truculents et attachants va se regrouper autour d’eux. S’appuyant sur l’article 1587 du Code civil, ils déclenchent un joyeux foutoir et retrouvent le plaisir du bien-vivre ensemble.