In Texas 1858, the Speck brothers, Ace and Dicky, drive black slaves on foot. Among the shackled slaves is Django, sold off and separated from his wife, Broomhilda von Shaft. The Speck brothers are stopped by Dr. King Schultz, a German ex-dentist and bounty hunter from Düsseldorf, Prussia. Schultz asks to buy one of the slaves; when he questions Django about his knowledge of the Brittle brothers, for whom Schultz is carrying a warrant, Ace becomes irritated and aims his shotgun at Schultz. Schultz quickly kills Ace and leaves Dicky at the mercy of the newly freed slaves, who shoot Dicky in the head.
The Man with No Name—"Monco"/"Manco"— and Colonel Douglas Mortimer—the "Man in Black"—are two bounty hunters in pursuit of "El Indio," one of the most wanted fugitives in the Wild West, and his gang. El Indio is ruthless, clever, and brutal. He has a musical pocketwatch that he plays before engaging in gun duels: "When the chimes finish, begin," he says. Flashbacks reveal that El Indio took the watch from a young woman whom El Indio found with her lover (in Joe Millard's novelization of the film, her newly wed husband), killed him, and raped her; she killed herself while being raped. There is a photograph of the woman inside the cover of the watch; it was a gift from her lover (in the novelization, it was a wedding gift from her brother).
A stranger arrives at the little Mexican border town of San Miguel. Silvanito, the town's innkeeper, tells the Stranger about a feud between two families vying to gain control of the town: on the one side, the Rojo brothers: Don Miguel, Esteban and Ramón; on the other, the family of the town sheriff, John Baxter. The Stranger decides to play each family against the other in order to make money, and proves his speed and accuracy with his gun to both sides by shooting the four men who teased him as he entered town with ease.
A single stranger named Hud comes to Blackstone, a town where his brother had been falsely accused of robbing a bank. Hud he is determined to avenge his brother, who has been hanged without a proper court hearing. Finally Hud finds out it was one of the town's most dignified citizens who really robbed the bank. That puts him in great danger.
Django is a drifter who drags a closed coffin around with him. He rescues a young woman, María, who is about to be murdered by bandits led by Major Jackson (Eduardo Fajardo), the man whom Django is seeking and wants to kill in revenge for him for killing his wife. After killing most of Jackson's men, Django makes a deal with a Mexican bandit general, Hugo Rodriguez, who is in conflict with Jackson, and the two steal a large quantity of gold from a Mexican Army fort (where Jackson is doing business with a government general). When Rodriguez refuses to give Django his share of the haul, Django and Maria steal the gold. Unfortunately, the gold falls into quicksand. When Rodriguez catches up to them, María is shot (though she survives) and Django's hands are crushed by Rodriguez's men as punishment for being a thief. When the bandits return to Mexico, Rodríguez and his men are massacred by Jackson and the Mexican Army. After killing Nathaniel, Jackson goes looking for Django in a cemetery. However, Django, who has bitten off the trigger-guard of his pistol, kills Jackson and his five surviving men by pressing the trigger of his gun against the cross of the grave of a female acquaintance of Django's whom Jackson had killed and repeatedly dropping the hammer.
A young rancher, swindled in a cattle deal, kills a rancher, in self-defense, who has accused him of stealing his cattle. He then gets caught up in adventure and romance as he tries to prove his innocence and clear his name.
Scott, fils d'une prostituée, est le souffre douleur de la petite ville tranquille de Clifton. Un jour, le pistolero Talby débarque et, en prenant la défense du jeune homme, tue un homme. Il est relâché pour légitime défense et prend sous son aile Scott, qui s'avère être un excellent tireur. Le maître et l'élève décident de se venger des notables de Clifton et prennent peu à peu le contrôle de la ville avant de s'opposer...
Bill (John Phillip Law), a boy whose father was killed and mother and sister were raped and murdered in front of him by a gang, sets out 15 years later to exact revenge, having used the time to become an expert marksman with a gun.
Lors de la guerre de Sécession, le commandement sudiste confie à sept mercenaires la tâche de s'emparer d'un chargement d'or de l'Union, destiné à payer des armes et caché dans une mine où est entreposé un dépôt de munitions. Avec à sa tête Clyde, le commando déjoue les lignes ennemies, réussit à pénétrer dans la poudrière et à s'emparer du précieux butin. Clyde décide alors de se l'approprier et s'enfuit. Retrouvé par ses acolytes, une lutte impitoyable pour la possession de l'or s'engage alors, à laquelle participe Lynch, un capitaine traître sudiste du contre espionnage, passé à l'ennemi.
Having massacred an Indian village, outlaw Duncan finds his men falling victim to a solitary rider, Navajo Joe. Joe saves three prostitutes who have overheard Duncan plot with Lynne, the town doctor, to steal a train full of money belonging to the bank. Joe steals the train back from Duncan's gang. He asks the townspeople of Esperanza to pay him to protect them from Duncan, making an offer of "I want a dollar a head from every man in this town for every bandit I kill". The townspeople reject him, as they "don't make bargains with Indians." Lynne's wife Honor persuades them otherwise. Joe sets a trap for Duncan but is caught and tortured; Lynne and Honor are killed. Rescued by an old man from the saloon, Joe again steals the train and eradicates Duncan's gang. There is then a showdown in an Indian cemetery, where Joe reclaims the pendant which Duncan stole from his wife when he murdered her. As Joe turns, Duncan shoots Joe with a hidden gun. Injured, Joe grabs a tomahawk and throws it, hitting Duncan square in the forehead. With Duncan dead, Joe sends his horse back to town, carrying the Bank's money.
Colonel Jonas is a fanatical and unrepentant Confederate who led a regiment called the Hellbenders in the recently ended Civil War. Similar to Edmond O'Brien's character in Rio Conchos, he is determined to reorganise the Southern Army and defeat the Union. With his sons Ben, greedy Nat, and rapist Jeff, he massacres Union soldiers transporting a consignment of banknotes and conceals the loot in a coffin supposedly belonging to a deceased Confederate officer, Captain Ambrose who was killed in the Battle of Nashville.
Professor Brad Fletcher (Volontè), a teacher from New England, leaves his job and travels to Texas due to his ill health. After arriving in the west, he ends up taken hostage by a wounded outlaw, Solomon "Beauregard" Bennet (Milian). Fletcher helps Bennet regain his health and manages to convince Bennet that he is more valuable to him alive than dead. Through their uneasy friendship, Fletcher takes an interest in the outlaw way of life. Instead of returning home, he decides to join the "Bennet's Raiders".
Jack Beauregard (Henry Fonda) is an aging legendary gunslinger who wants to retire in peace in Europe to get away from young gunmen constantly trying to test themselves against the master. The film opens with three gunmen attempting to ambush Beauregard in a barbershop. After Beauregard has dispatched them, the barber's son asks his father if there is anyone in the world faster than Beauregard, to which the barber replies "Faster than him? Nobody!"