In the future, robots known as Sentinels are exterminating mutants and their human allies. A band of mutants, including Kitty Pryde, Colossus, Iceman, Bishop, Warpath, Blink and Sunspot, evade the Sentinels due to Pryde's ability to send a person's consciousness to the past. Pryde's group convenes with Logan, Storm, Professor Charles Xavier, and Erik Lehnsherr at a monastery in China. Pryde sends Logan's consciousness 50 years back in time to 1973 to prevent Mystique from assassinating Dr. Bolivar Trask, creator of the Sentinels. Following the assassination, Mystique was captured, and her DNA was used by Trask's company to improve the Sentinels, whose ability to adapt to any mutant power makes them almost invincible. Xavier and Lehnsherr advise Logan to find both of their younger selves for help.
Six months after the events of the first film, Neo and Trinity are now lovers. Morpheus receives a message from Captain Niobe of the Logos calling an emergency meeting of all of Zion's ships. Zion has confirmed the last transmission of the Osiris: an army of Sentinels is tunneling towards Zion and will reach it within 72 hours. Commander Lock orders all ships to return to Zion to prepare for the onslaught, but Morpheus asks one ship to remain in order to contact the Oracle. The Caduceus receives a message from the Oracle, and the Nebuchadnezzar ventures out so Neo can contact her. One of the Caduceus crew, Bane, encounters Agent Smith, who takes over Bane's avatar. Smith then uses this avatar to leave the Matrix, gaining control of Bane's real body.
Dr. Ryan Stone (Sandra Bullock) is a biomedical engineer aboard the NASA space shuttle Explorer for her first space mission, STS-157. Veteran astronaut Matt Kowalski (George Clooney) is commanding his final mission. During a spacewalk to service the Hubble Space Telescope and Stone's upgrades to the Telescope, Mission Control in Houston warns the team about a Russian missile strike on a defunct satellite, which has inadvertently caused a chain reaction forming a cloud of debris in space. Mission Control orders that the mission be aborted and the crew begin re-entry immediately because the debris is speeding towards the shuttle. Communication with Mission Control is lost shortly thereafter.
Two years after the Battle of New York, Steve Rogers works in Washington D.C. for the espionage agency S.H.I.E.L.D. under Director Nick Fury, while adjusting to contemporary society. Rogers and Agent Natasha Romanoff are sent with S.H.I.E.L.D.'s counter-terrorism S.T.R.I.K.E. team, led by Agent Rumlow, to free hostages aboard a S.H.I.E.L.D. vessel from Georges Batroc and his mercenaries. Mid-mission, Rogers discovers Romanoff has another agenda: to extract data from the ship's computers for Fury. Rogers returns to the Triskelion, S.H.I.E.L.D.'s headquarters, to confront Fury and is briefed about Project Insight: three Helicarriers linked to spy satellites, designed to preemptively eliminate threats. Unable to decrypt the data recovered by Romanoff, Fury becomes suspicious about Insight and asks senior S.H.I.E.L.D. official Alexander Pierce to delay the project.
Ten years after the worldwide pandemic of the deadly ALZ-113 virus (known as the Simian Flu), human civilization is completely destroyed following martial law, civil unrest and the economic collapse of every country in the world. Over 90% of the human population has died in the pandemic, while apes with genetically enhanced intelligence have started to build a civilization of their own.
Many years ago, the planet Cybertron was consumed by a civil war by the two Transformer factions, the Autobots led by Optimus Prime, and the Decepticons led by Megatron. Optimus jettisoned the AllSpark, a mystical artefact that brings life to the planet, into space, but Megatron pursued it. Megatron crashed in the Arctic Circle and froze, discovered in 1897 by explorer Archibald Witwicky. Witwicky activated Megatron’s navigational system, which scanned the AllSpark’s coordinates into his glasses. The glasses end up in the possession of his great-great-grandson Sam Witwicky. In the present day, Sam buys his first car, a rusting Chevrolet Camaro, but discovers it has a life of its own.
OsCorp scientist Richard Parker records a video message to explain his disappearance. Later, he and his wife, Mary, are aboard a private jet hijacked by a man sent to assassinate Richard. The plane crashes, killing both Richard and Mary, after he uploads the video.
À Derry, dans le Maine, sept enfants ayant du mal à s'intégrer se sont regroupés au sein du « Club des Ratés ». Rejetés par leurs camarades, ils sont les cibles favorites des gros durs de l'école. Ils ont aussi en commun le fait d'avoir éprouvé leur plus grande terreur face à un terrible prédateur métamorphe qu'ils appellent « Ça ». Car depuis toujours, Derry est en proie à une créature qui émerge des égouts tous les 27 ans pour se nourrir des terreurs de ses victimes de choix : les enfants. Bien décidés à rester soudés, les Ratés tentent de surmonter leurs peurs pour enrayer un nouveau cycle meurtrier. Un cycle qui a commencé un jour de pluie lorsqu'un petit garçon poursuivant son bateau en papier s'est retrouvé face-à-face avec un clown répondant au nom de Grippe-Sou.
In Seattle, not far from Forks, Victoria (Bryce Dallas Howard) attacks and bites Riley Biers (Xavier Samuel), in order to begin creating an army of newborns with him. Back in Forks, Edward Cullen (Robert Pattinson) and Bella Swan (Kristen Stewart) discuss the complications of becoming an immortal vampire. At 18 years old, one year older than the age Edward was when he became a vampire, Bella expresses her aversion to the idea of marrying so young, though Edward refuses to turn her into a vampire until they are married, his argument that she should have various human experiences she would otherwise miss. While Charlie Swan (Billy Burke) investigates the disappearance of Riley Biers, Edward suspects his disappearance was caused by the newborn vampires, furthering his suspicions is Riley's intrusion into Bella's room.
In Budapest to intercept a courier working for an individual code-named "Cobalt", IMF agent Trevor Hanaway is killed by assassin Sabine Moreau. Hanaway's team leader, Jane Carter, and newly promoted field agent Benji Dunn extract Ethan Hunt and his source, Bogdan, from a Moscow prison. Ethan is recruited to lead Jane and Benji to infiltrate secret Moscow Kremlin archives and locate files identifying Cobalt. During the mission, someone broadcasts across the IMF frequency, alerting the Russians to Ethan's team. Although Benji and Jane escape, a bomb destroys the Kremlin and SVR agent Anatoly Sidorov arrests Ethan, suspecting him as a key player in the attack.
In District 12, Katniss Everdeen volunteers when her younger sister Primrose is initially chosen by lot. She and the male Tribute, Peeta Mellark, are escorted to the Capitol by chaperone Effie Trinket and their mentor Haymitch Abernathy, a past District 12 victor and alcoholic. Haymitch impresses on them the importance of gaining sponsors, as they can provide gifts of food and supplies during the Games. During part of a series of televised interviews, Peeta publicly expresses his love for Katniss, which she initially takes as an attempt to earn sponsor favor, but later learns his love is genuine. While training, Katniss observes the Career Tributes Marvel, Glimmer, Cato, and Clove, from Districts 1 and 2, who have been training for the Games since a young age.
After intercepting nerve gas being sold to terrorists, Impossible Missions Force (IMF) agent Ethan Hunt (Tom Cruise) is convinced he can prove the existence of the Syndicate, an international criminal consortium that the Central Intelligence Agency (CIA) does not believe exists. Hunt is captured by the Syndicate, but escapes a torture chamber led by Syndicate member Janik "Bone Doctor" Vinter (Jens Hultén) with the help of MI6 agent and Syndicate operative Ilsa Faust (Rebecca Ferguson).
Dr. Malcolm Crowe, a child psychologist in Philadelphia, returns home one night with his wife, Anna, after having been honored for his work. Anna tells Malcolm that everything is second to his work, and that she believes he is truly gifted.
The planet Krypton faces imminent destruction due to its unstable core; the result of depleting Krypton's natural resources. The ruling council is deposed by the planet's military commander, General Zod, and his followers during a coup d'état. Knowing that artificial population control and isolationism have ruined their civilization, scientist Jor-El and his wife Lara launch their newborn son, Kal-El, the first naturally born Kryptonian child in centuries, on a spacecraft to Earth after infusing his cells with a genetic codex of the entire Kryptonian race. After Zod kills Jor-El, he and his followers are captured and exiled to the Phantom Zone. However, they are indirectly freed after Krypton explodes, rendering the Kryptonian race extinct apart from Zod and his forces.
John Hancock (Will Smith) is an alcoholic man with superhero powers, including flight, invulnerability, and super-strength. Though he uses his powers to stop criminals in his current residence of Los Angeles, his activity inadvertently causes millions of dollars in property damage due to his constant intoxication. As a result, he is routinely jeered at the crime scenes. Hancock also ignores court subpoenas from the city of Los Angeles to address the property damage he has caused.