A man revealed to be Jacques Saunière is being pursued by a mysterious hooded character known as Silas (Paul Bettany) through the Grand Gallery in the Louvre in Paris. Silas demands the location of the Priory's clef de voûte or "keystone." Under threat of death, Saunière finally confesses the keystone is kept in the sacristy of Church of Saint-Sulpice, "beneath the Rose." Silas thanks him, and then shoots him in the stomach. Meanwhile, American symbologist Robert Langdon (Tom Hanks), who is in Paris as a guest lecturer on symbols and the sacred feminine, is contacted by the French police, and summoned to the Louvre to view the crime scene. He discovers the dying Saunière has created an intricate display using black light ink and his own body and blood. Captain Bezu Fache (Jean Reno) asks him for his interpretation of the puzzling scene.
Ellie and Manny are expecting their first child, and Manny is obsessed with making life perfect and safe for the family, since his first experiences as a husband and father went bad when his family were killed by hunters. At the same time, Diego finds himself unable to catch a cocky gazelle he has been stalking and decides to leave the herd, believing that he is losing his predatory nature as a tiger. Sid grows jealous of Manny and Ellie and “adopts” three apparently abandoned eggs that he finds in an icy underground cavern and call them Egbert, Shelly, and Yoko. Manny tells him to put them back, but Sid instead looks after the eggs, which hatch into baby Tyrannosaurus the next morning.
In Seattle, not far from Forks, Victoria (Bryce Dallas Howard) attacks and bites Riley Biers (Xavier Samuel), in order to begin creating an army of newborns with him. Back in Forks, Edward Cullen (Robert Pattinson) and Bella Swan (Kristen Stewart) discuss the complications of becoming an immortal vampire. At 18 years old, one year older than the age Edward was when he became a vampire, Bella expresses her aversion to the idea of marrying so young, though Edward refuses to turn her into a vampire until they are married, his argument that she should have various human experiences she would otherwise miss. While Charlie Swan (Billy Burke) investigates the disappearance of Riley Biers, Edward suspects his disappearance was caused by the newborn vampires, furthering his suspicions is Riley's intrusion into Bella's room.
In 17,000 B.C., the Seven Primes traveled the galaxy to create Energon with star-absorbing machines called Sun Harvesters. The Primes followed a rule in which to never destroy planets with life, but one of them, later called The Fallen, deceives the others by building an army and sets up a Harvester on Earth. After defeating ancient humans, the Primes defeat and imprison the Fallen before he can harvest the Earth's sun with the Matrix of Leadership. The rest of the Primes sacrifice themselves to hide the Matrix.
A massive meteor shower destroys the orbiting Space Shuttle Atlantis and bombards a swath of land from America's East Coast from South Carolina through Finland. NASA discovers that a rogue asteroid the size of Texas passed through the asteroid belt and pushed forward a large amount of space debris. The asteroid will collide with Earth in 18 days, causing an extinction event that will even wipe out bacteria. NASA scientists, led by Dan Truman, plan to trigger a nuclear detonation 800 feet (240 m) inside the asteroid to split it in two, driving the pieces apart so both will fly past the Earth. NASA contacts Harry Stamper, considered the best deep-sea oil driller in the world, for assistance. Harry travels to NASA with his daughter Grace, to keep her away from her new boyfriend and one of Harry's drillers, A. J. Frost. Harry explains he will need his team, including A. J., to carry out the mission. They agree to help, but only after their list of unusual rewards and demands are met.
On the morning of June 6, 1944, the beginning of the Normandy Invasion, American soldiers prepare to land on Omaha Beach. They suffer heavily from their struggle against German infantry, machine gun nests, and artillery fire. Captain John H. Miller, a company commander of the 2nd Ranger Battalion, survives the initial landing and assembles a group of his Rangers to penetrate the German defenses, leading to a breakout from the beach. In Washington, D.C, at the U.S. War Department, General George Marshall is informed that three of the four brothers of the Ryan family were killed in action and that their mother is to receive all three telegrams in the same day. He learns that the fourth son, Private First Class James Francis Ryan, is a paratrooper and is missing in action somewhere in Normandy. Marshall, after reading Abraham Lincoln's Bixby letter, orders that Ryan must be found and sent home immediately.
Dominick "Dom" Cobb (Leonardo DiCaprio) and Arthur (Joseph Gordon-Levitt) are "extractors", people who perform corporate espionage using an experimental military technology to infiltrate the subconscious of their targets and extract information while experiencing shared dreaming. Their latest target is Japanese businessman Saito (Ken Watanabe). The extraction from Saito fails when sabotaged by a memory of Cobb's deceased wife Mal (Marion Cotillard). Saito reveals that he was actually auditioning the team to perform the difficult act of "inception": planting an idea in a person's subconscious.
In AD 180, Spanish-Roman General Maximus Decimus Meridius leads the Roman army to a decisive victory against the Germanic tribes near Vindobona, ending a long war on the Roman frontier and winning the favor of the Emperor Marcus Aurelius. Maximus, weary of battle, decides to retire at his Spanish farm estate at the Emperor's behest, but the Emperor tells him that his son and heir to the throne, Commodus, is unfit to rule and thus appoints him as regent to help save Rome from corruption. Before he makes his decision, Commodus is confronted by his father who tells him that he will not be emperor. Burdened by grief and believing he was never valued by his father, Commodus kills him.
On her 18th birthday, Bella Swan wakes up from a dream in which she sees herself as an old woman. She expresses her distaste about growing older than her boyfriend Edward Cullen, a vampire who stopped aging physically at 17. Despite her lack of enthusiasm, Edward's adoptive family throw Bella a birthday party. While unwrapping a gift, Bella gets a paper cut. Edward's brother, Jasper, becomes overwhelmed by the scent of Bella's blood and attempts to kill her. Realizing the danger that he and his family pose to Bella, Edward ends their relationship, and the Cullens leave Forks, Washington.
In 1961, the Ark, a Cybertronian spacecraft carrying an invention capable of ending the war between the Autobots and Decepticons, lands on the far side of the Earth's Moon. The crash is detected on Earth by NASA, and President John F. Kennedy authorizes a mission to put a man on the Moon as a cover for investigating the craft. In 1969, the crew of Apollo 11 lands on the Moon to explore the craft.
After a failed attempt to rescue his first mate, Joshamee Gibbs, in London, Captain Jack Sparrow is brought before King George II, who wants Jack to guide an expedition to the Fountain of Youth before King Ferdinand and the Spanish Navy can locate it. Heading the expedition is Jack's old nemesis, Captain Hector Barbossa, now a privateer in service to the British Navy after losing his leg and ship, the Black Pearl, which he believes to be sunk.
Bella Swan is getting ready for her wedding. During the reception, her best friend, Jacob Black the were-wolf returns after hearing about Bella and Edward's engagement. While dancing with him in the woods, away from everyone else, Bella admits that she and Edward plan to consummate their marriage on their honeymoon while she's still human. Jacob becomes furious, knowing that Edward could easily kill Bella but the other wolves restrain him from hurting Edward.
In District 12, Katniss Everdeen volunteers when her younger sister Primrose is initially chosen by lot. She and the male Tribute, Peeta Mellark, are escorted to the Capitol by chaperone Effie Trinket and their mentor Haymitch Abernathy, a past District 12 victor and alcoholic. Haymitch impresses on them the importance of gaining sponsors, as they can provide gifts of food and supplies during the Games. During part of a series of televised interviews, Peeta publicly expresses his love for Katniss, which she initially takes as an attempt to earn sponsor favor, but later learns his love is genuine. While training, Katniss observes the Career Tributes Marvel, Glimmer, Cato, and Clove, from Districts 1 and 2, who have been training for the Games since a young age.
In the 1880s, an English couple and their infant son escape a burning ship, ending up on land near uncharted rainforests off the coast of Africa. The couple craft themselves a treehouse from their ship's wreckage, but are subsequently killed by Sabor, a rogue leopardess. Kala, a female gorilla who recently lost her own child to Sabor, hears the cries of the orphaned human infant and finds him in the ruined treehouse. Though she is attacked by Sabor, Kala and the baby manage to escape. Kala takes the baby back to the gorilla troop to raise as her own, an act of which her mate, Kerchak, disapproves. Kala raises the human child, naming him Tarzan. Though he befriends other gorillas in the troop and other animals, including the young female gorilla Terk and the paranoid male elephant Tantor, Tarzan finds himself unable to keep up with them, so he takes great efforts to improve himself. As a young man, Tarzan is able to kill Sabor with his crude spear and protect the troop, gaining Kerchak's reluctant respect.
Gaylord "Greg" Focker (Ben Stiller) and his fiancée Pam Byrnes (Polo) decide to introduce their parents to each other. They first fly to Oyster Bay, New York, on Long Island, to pick up Pam's father, retired CIA operative Jack Byrnes (De Niro), her mother Dina (Danner) and one-year-old nephew Little Jack. But rather than going to the airport as planned, Jack decides to drive the family to Miami to meet the Fockers in his new RV.