The setting begins with the introduction of Scott Murphy, former high school football hero. An injury he received during the Ohio State High School Championship game terminated his scholarship to Ohio State and his dreams of a professional career in football. It's been twenty years since that game and Scott still resides with his family in the quiet town of Coldwater, Ohio. He has a splinted leg and has been a farmer since high school. Rather than marrying the head cheerleader, Scott marries and has two daughters with a clarinet-playing band member named Macey. Difficulties with a compromised harvest and bank obligations have caused strain on his farm, which he is in jeopardy of losing. With bad luck around every corner, Scott is not mentally prepared for the game in which he will be honored (in a halftime ceremony), and the return of his good friend who made the NFL only adds to the depression he is feeling. An early frost and a broken soybean header bring Scott to the brink. His wife, Macey, suggests that they could pick the soybeans by hand in order to bring them to market. Scott finds this far-fetched since there are 200 acres to combine (harvest). He decides to kill himself via CO poisoning in his truck, at least his wife and two girls will receive the life insurance bonus – which is another mistake since a suicide death will not activate a life insurance payout. As he passes out, Scott wakes up back in 1991, on the eve of the big game.
High-school Nerd Ed Wallis (Nat Wolff) enters into a friendship with his neighbor, Ashby (Mickey Rourke), a retired CIA assassin who only has a few months to live.
State College football coach George Cooper (Fred MacMurray) has more than enough problems on the job without his teenage daughter Connie (Betty Lynn) complicating his life at home.
Injured and out of shape, "Hurricane" Harry Joplin is unhappy about not being accepted for World War II duty by the Navy and unhappier still when the New York Titans decline to offer him a new contract, suggesting he become a coach instead. Harry refuses to believe his football days are over.
Harvard University student Tom Brown (William Haines) is a handsome, athletic, and carefree young man who has a reputation as a Don Juan among the ladies. Although he is popular on campus, he finds himself at odds with Bob McAndrew (Ralph Bushman), a studious, reserved boy who becomes his chief rival for the affections of beautiful Mary Abbott (Mary Brian), a professor's daughter. Tom rooms with Jim Doolittle (Jack Pickford), an awkward weakling but goodhearted backwoods youth who idolizes him. The brash and cocky Brown easily wins over his dormitory mates, but refuses to let them ostracize Jim.
Jock Hamill est la vedette de l'équipe de football de son université. Des problèmes surviennent lorsque Eunice Hathaway, une ancienne petite amie, cherche à le séduire alors qu'elle est désormais la femme de l'entraîneur de l'équipe. L'entraîneur se suicide, Eunice pousse Jock à la demander en mariage, Jock est suspecté d'avoir tué l'entraîneur... Mais tout finira bien et Jock retrouvera son véritable amour Cecily.
Marty Reid, le quarterback vedette de l'équipe de l'université, est souvent mis sur la touche et il jure de ne plus jouer au football. Il va y être poussé par l'attitude d'Ed Kirby à son égard...
Red Grange is thrown off the Clay College football team in disgrace when his friend, Buddy Courtland, takes a bribe to throw the big game and Red attacks him. Red then proceeds to investigate and hunt down the head of the gambling ring responsible. Red eventually clears his name and both he and Buddy are reinstated on the team.
Due to a misunderstanding, Yale inadvertently invites the small Texas State University to come to Connecticut and play against its football team for a benefit game. Coincidentally, TSU has just hired a new coach, Slug Winters (Jack Haley), who arrives at the college with his wife Bessie (Patsy Kelly) just in time to hear the announcement that the team is to play Yale.
Lars Knutson Rockne moves his family from Norway in 1892, settling in Chicago. His son Knute saves up his money and enrolls in college at the Notre Dame campus in South Bend, Indiana, where he plays football.
Star professional quarterback Pete Wilson (Victor Mature) thinks nothing of his future after football, not even after longtime teammate Bill "Holly" Holloran (Gordon Jones) is released by the team. Pete gets advance after advance on his salary from Anne (Lucille Ball), the secretary of team owner and coach Lenahan (Lloyd Nolan).