In 2009, a genetically re-engineered measles virus, originally created as a cure for cancer, turns into a lethal strain which kills 90% of those it infects, and mutates the remaining 10% into predatory, nocturnal mutants called "Darkseekers" who are extremely vulnerable to sunlight and other sources of UV. Three years after the outbreak, US Army virologist Lieutenant Colonel Robert Neville (Will Smith) lives an isolated life in the ruins of New York City, which is now deserted, unsure if any other uninfected humans are left in the world.
A zombie outbreak erupts in metropolitan areas around the world; those bitten by the creatures become zombies themselves within twelve seconds. Retired UN investigator Gerry Lane, his wife Karen, and their two daughters manage to escape the outbreak in Philadelphia and take shelter with a family in Newark while waiting for special evacuation the next day, thanks to Gerry's friend UN Deputy Secretary-General Thierry Umuntoni. They find a shelter for the night while waiting for a rescue helicopter. Their hosts choose not to accompany them when they flee the next day, and are subsequently bitten and changed by zombies. Their son, Tommy, manages to escape, and Gerry's family takes him in. They are flown to an offshore U.S. Navy carrier group near New York where Umuntoni is overseeing the remaining worldwide governments' reactions.
A year after the events of Extinction, the Alice clones (Milla Jovovich) attempt to kill Albert Wesker (Shawn Roberts) at the current Umbrella Headquarters, Tokyo. The clones manage to kill the entire branch, but Wesker makes his way to his private charter tiltrotor plane and escapes before activating a bomb, leaving a massive sinkhole. However, the real Alice boarded his aircraft beforehand. As she pulls a gun on him, Wesker injects her with Anti-Virus before the lack of a pilot makes the aircraft crash in the mountains outside Tokyo. Only Alice emerges from the crash alive.
Alice (Milla Jovovich) and the others on the Umbrella Corporation freighter Arcadia face an attack by a fleet of tiltrotors led by Alice's former ally, Jill Valentine (Sienna Guillory), who is being mind controlled by Umbrella through a scarab device attached to her chest. Alice causes a tiltrotor to crash into Arcadia, resulting in an explosion that knocks her out and into the water. The fates of Chris Redfield, Claire Redfield and K-Mart are ambiguous.
Motaba, a fictional virus which causes a deadly fever, is discovered in the African jungle in 1967. To keep the virus a secret, U.S. Army officers Donald McClintock (Donald Sutherland) and William Ford (Morgan Freeman) destroy the camp where it was found.
In New York City's Central Park, people begin committing mass suicide. Initially believed to be caused by a bio-terrorist attack using an airborne neurotoxin, the behavior quickly spreads across the northeastern United States. Elliot Moore, a high school science teacher in Philadelphia, hears about the attacks and decides to go to Harrisburg by train with his wife, Alma. They are accompanied by his friend Julian and Julian's eight-year-old daughter Jess. Julian's wife is stuck in Philadelphia but is expected to meet them in Harrisburg. The train loses all radio contact en route and stops at a small town. They receive word that Philadelphia has been attacked by the toxin and Julian's wife was not able to get on the train to Harrisburg. Julian decides to go look for her, leaving his daughter with the Moores while he hitches a ride. However, the town has already been hit by the toxin. Succumbing to it, the driver and Julian both commit suicide.
Alice (Milla Jovovich) wakes up disoriented in a mansion. She wanders through the halls, where she defeats several obstacles, including a laser beam obstacle (from the first film) and a giant blade that falls from the ceiling. However, she is eventually killed by a miniature machine gun. Her body is dumped into a pit filled with hundreds of Alice clones. The camera zooms out to show a shack camouflaging the facility's above-ground entrance - with the rest of the facility located underground, surrounded by a high fence and thousands of zombies.
Returning from a Hong Kong business trip, Beth Emhoff has a layover in Chicago to have sex with a former lover before returning to her family in suburban Minneapolis. She appears to have contracted a cold during her trip. Her six-year-old son from a previous marriage, Clark, also becomes symptomatic and is sent home from school. Beth's condition worsens and two days later she collapses with severe seizures. Her husband, Mitch, rushes her to the hospital, but she dies of an unknown cause.
30 days after the contamination of The Hive seen in Resident Evil (2002), the Umbrella Corporation unwisely sends in a research team to re-open the complex and investigate the incident, since no one survived except Alice and Matt Addison, and as Alice was experimented on, Matt was put into a mysterious "Nemesis Program". When the team reprograms and opens the sealed blast doors, they are slaughtered by the massive crowd of infected.
Underneath Raccoon City exists a genetic research facility called the Hive, owned by the Umbrella Corporation. A thief steals the genetically engineered T-virus and contaminates the Hive with it. In response, the facility's artificial intelligence, the Red Queen, seals the Hive and kills everyone inside.
Un chauffeur de camion est arrêté sur une petite route par des hommes portant des tenues de protection contre les risques biologiques. Ils désinfectent son véhicule avant de le laisser passer. Peu après, il percute une biche qui, bien que morte, se relève.
In Cambridge, three animal liberation activists break into a medical research laboratory with the intent of freeing captive chimpanzees. They are interrupted by a scientist, who desperately warns them that the chimps are infected with a highly contagious rage-inducing virus that is spread through blood and saliva. Ignoring the scientist's pleas, the activists release a chimpanzee, who attacks one of them and immediately infects her — leading her to attack and infect everyone else present.
During the original outbreak of the Rage Virus, Don, his wife Alice, and four other survivors hide in a barricaded cottage on the outskirts of London. They hear a terrified boy pounding at their door, and let him in. A few minutes later, they discover that the infected have followed the boy to them. The infected attack and kill most of the survivors, while Don, Alice, and the boy are chased upstairs. Don is separated from Alice and when the boy is seen hiding in the closet. Alice rushes to get the boy, while Don tells her to just leave him. Soon the infected break into the room and after Alice pleading with Don to "help us", he decides to leave, abandoning them. Don desperately sprints to a nearby motorboat and narrowly escapes.
In 2008, an unknown killer virus, dubbed "The Reaper Virus" infects Scotland. The UK government cannot contain or cure the virus, and they decide to build a 60-foot containment wall over the border with Scotland and its islands, isolating it from the rest of Britain.
Ten years after a covert military experiment on a remote Pacific island went wrong and killed eighteen servicemen and his assistant, Dr. Richard Long (David Paymer) is still trying to forget the havoc and death that his experiment caused.