Set twenty-five years after Child's Play, the Chucky doll (voiced by Brad Dourif) mysteriously arrives in the mail of the home of paraplegic Nica Pierce (Fiona Dourif) and her mother, Sarah. Later that night Sarah is found dead from a stab wound and her death proclaimed a suicide.
Shortly after the events of the previous film, Tiffany (Jennifer Tilly), a former girlfriend and accomplice of serial killer Charles Lee Ray (voice of Brad Dourif), acquires the remains of Chucky from a police evidence locker after bribing and then murdering a police officer with access to the locker. Assuming that Ray's soul still inhabits the doll, Tiffany takes it back to her place. She crudely stitches Chucky back together and reenacts the voodoo ritual which instilled Ray inside the doll ten years ago.
Charles Lee Ray also nicknamed 'Chucky' and the 'Lakeshore Strangler' is a wanted fugitive and is on the run from the police in the streets of Chicago in November 1988. After he is fatally shot by Detective Mike Norris, Charles via a voodoo ritual transfers his soul into a 'Good-Guy' doll which destroys the store in an attempt to cheat death. Mike who survives the explosion finds Charles's body thinking he killed him.
Two years after Chucky was burned to a crisp and shot in the heart by detective Mike Norris, the killer "Good Guys" doll (voiced by Brad Dourif) is rebuilt from scratch by the Play Pals doll company to prove there is no fault with the dolls. The company had gone downhill ever since Andy Barclay (Alex Vincent) blamed Chucky for all the murders the doll committed two years prior. One of the men working on Chucky is killed via electrocution. The CEO of the company Mr. Sullivan (Peter Haskell) orders his assistant Mattson (Greg Germann) to cover the accident and get rid of Chucky.
Six years after the events of the previous film, Glen, the kind and gentle son of Chucky and Tiffany, has a nightmare in which he murders a little girl's parents. In reality, he is living a life of embarrassment and abuse as a ventriloquist's dummy from his own point of view. Desperate to know his parents, Glen tracks Chucky and Tiffany down to Hollywood, where they are first shown killing a man who is dressed as Santa Claus for a movie. Upon tracking down his mom and dad, who are now dummies in one of Jennifer Tilly's films, Glen uses a voodoo amulet to bring them back to life. When Chucky (voice of Brad Dourif) finds out that Glen is his child, he faints, while Tiffany is ecstatic and hugs her child. Tiffany and Chucky argue over whether Glen is male or female, due to his lack of genitals (though he is clearly a male). Chucky decides to continue labeling him as a boy, whereas Tiffany labels him as a girl, calling him "Glenda".
Eight years after the events of Child's Play 2, The Play Pals (Good Guys) has recovered from bad publicity arising from Chucky's (Brad Dourif) murder spree. The company releases a new line of Good Guy dolls and recycles Chucky's remains. However, the soul of serial killer Charles Lee Ray still inhabits the remains, and Chucky is soon revived. Chucky is unwittingly given to Play Pals' CEO Mr. Sullivan, whom Chucky tortures and kills using various instruments. He then uses computer records to relocate Andy Barclay (Justin Whalin).
Quatre ans après les événements de La Malédiction de Chucky, Nica est enfermée dans un asile psychiatrique après avoir été condamnée à tort pour le meurtre de sa famille. Quand une nouvelle poupée Brave Gars fait son apparition dans un but thérapeutique, une nouvelle série de meurtres se produit aussitôt. Andy Barclay est le seul à pouvoir venir en aide à Nica et vaincre Chucky, une bonne fois pour toutes..