En 1998, trois ans après avoir écarté la menace de Skynet, Sarah et John Connor profitent de la vie sur une plage de Livingston, au Guatemala, lorsqu'ils sont soudainement attaqués par un Terminator T-800. Renvoyé dans le temps par Skynet avant son effacement, le Terminator assassine John avant de disparaître.
L'an 2563, 300 ans après que la Terre a connu une catastrophe appelée "l'effondrement" consécutive à une guerre contre Mars. Dans la ville d'Iron City infestée par le crime, le Dr Dyson Ido, médecin spécialisé dans les augmentations biomécaniques, cherche des pièces détachées dans une décharge à ciel ouvert venant de Zalem, dernière cité céleste de la planète, surplombant Iron City, et où chacun rêve d'aller. Ido trouve le corps d'une cyborg en piteux état. Il va alors la ramener dans sa clinique pour la réparer. La jeune cyborg se réveille, réparée mais amnésique. Le docteur Ido la rebaptise Alita (du prénom de sa fille décédée) et lui fait découvrir le monde dans lequel ils survivent. Mais Alita se découvre des réflexes combatifs et une force surhumaine, veut toujours en savoir plus et aller plus loin. Elle fait la connaissance d'Hugo, un jeune revendeur de pièces détachées auquel elle se lie rapidement. Alita va tenter de comprendre qui elle est réellement et d'où elle vient. Elle croise la route du terrible Vector, qui contrôle les matches du sport ultra-populaire de la ville, le Motorball.
À Berlin en 2052, le chaos règne entre immigrants et autochtones dans cette ville où l'Est affronte l'Ouest. Leo Beiler (Alexander Skarsgård), un barman muet, est enlevé alors qu'il affronte les truands de sa ville afin de retrouver une femme disparue qui est sa seule raison de vivre. Durant sa plongée dans les entrailles de la ville, deux étranges chirurgiens américains (Paul Rudd et Justin Theroux) semblent être le seul fil rouge, et Leo ne sait pas s'il peut leur faire confiance.
En 2049, des humanoïdes issus du génie biologique, appelés réplicants, ont été intégrés dans la société pour assurer la survie de l'humanité. K, l'un des plus récents modèles conçus pour obéir, travaille comme blade runner au LAPD. Sa mission consiste surtout à pourchasser et éliminer les anciens modèles délinquants.
Dans un futur proche.
Le Major Mira Killian est unique en son genre. En effet, il y a un an, cette jeune femme a été sauvée d'un terrible accident en transférant son cerveau dans un corps synthétique aux capacités cybernétiques. À la suite de l'opération, elle a tout oublié de son passé. Elle a ensuite rejoint une unité d'élite anti-terroriste, la section 9, pour lutter aux côtés de Batou contre les plus dangereux criminels. Lorsque sévit une menace d'un nouveau genre, capable de pirater et de contrôler les esprits, le Major s'avère être la seule à pouvoir la combattre. Alors qu'elle s'apprête à affronter ce nouvel ennemi, elle découvre qu'on lui a menti ; sa vie n'a pas été sauvée, mais on la lui a volée. Rien ne l'arrêtera pour découvrir son véritable passé, trouver les responsables et les empêcher de recommencer avec d'autres cobayes.
Two decades after the events at Jurassic Park, a new theme park, Jurassic World, now operates in Isla Nublar, off the Pacific coast of Central America. This new park is run by the Masrani Global Corporation, which also owns InGen, the genetics company that creates the dinosaurs. Brothers Zach and Gray Mitchell are sent to visit their aunt, Claire, Jurassic World's operations manager. Claire's assistant greets them as she is too busy recruiting corporate sponsors.
At a nuclear plant in Chai Wan, Hong Kong, a hacker causes the coolant pumps to overheat and explode. Not long after in Chicago, the Mercantile Trade Exchange gets hacked, causing soy futures to rise. The Chinese government and the FBI determine that the hack was caused by a Remote Access Tool (RAT). A military officer in China's cyber warfare unit, Captain Chen Dawai (Leehom Wang), is tasked to find the people responsible for the attacks, and enlists the aid of his sister Chen Lien (Tang Wei), a networking engineer. He meets with FBI Agent Carol Barrett (Viola Davis) in Los Angeles and reveals the code in the RAT was written by himself and Nicholas Hathaway (Chris Hemsworth), his college roommate, in their school days years before Hathaway was sent to prison for an unrelated hack. Dawai asks that the FBI arrange for Hathaway to be released from prison, where he is serving a sentence for computer crimes. Hathaway is offered temporary release in exchange for his services.
Told from Igor's perspective, it shows the troubled young assistant's dark origins, his redemptive friendship with the young medical student Victor Frankenstein, and become eyewitnesses to the emergence of how Frankenstein became the man who created the legend we know today. The two's experiments eventually get them into trouble with the authorities and they are near to becoming fugitives as they complete their goals to use science to create life, with Frankenstein's ultimate endgame of creating a man.
In 2029, Human Resistance leader John Connor (Jason Clarke) launches a massive final offensive against Skynet, an artificial general intelligence system seeking to eliminate the human race. Before the Resistance wins the offensive, Skynet activates a time machine and sends back a T-800 Terminator to 1984 to kill John's mother, Sarah Connor (Emilia Clarke). John's right-hand man, Kyle Reese (Jai Courtney), volunteers to travel back in time to protect her. As Kyle floats in the machine's magnetic field, he witnesses John being attacked by another Resistance soldier (Matt Smith). He then has visions from his childhood about events in 2017.
OsCorp scientist Richard Parker records a video message to explain his disappearance. Later, he and his wife, Mary, are aboard a private jet hijacked by a man sent to assassinate Richard. The plane crashes, killing both Richard and Mary, after he uploads the video.
Ten years after the worldwide pandemic of the deadly ALZ-113 virus (known as the Simian Flu), human civilization is completely destroyed following martial law, civil unrest and the economic collapse of every country in the world. Over 90% of the human population has died in the pandemic, while apes with genetically enhanced intelligence have started to build a civilization of their own.
In 1795, Dr. Victor Frankenstein (Aden Young) creates a monster (Aaron Eckhart), a soulless creature patched together from corpses, and then rejects it, disgusted with what he's made. In a fit of rage, the creature kills Victor's wife Elizabeth (Virginie Le Brun) and Victor chases it to the Arctic to get revenge, but succumbs to the weather. The creature buries his creator in the Frankenstein family crypt and is then attacked by demons before being rescued by the gargoyles Ophir (Mahesh Jadu) and Keziah (Caitlin Stasey), who bring it before the gargoyle queen Leonore (Miranda Otto) and their commander Gideon (Jai Courtney). Leonore explains that they were created by the Archangel Michael to battle demons on Earth and protect humanity. They name the creature "Adam" and invite him to join them, but he declines and departs after being given heavy, baton-like weapons to protect him, as more demons will come after him. The weapons allow him to "descend" demons (destroying their bodies and trapping their souls in Hell) as they have the symbol of the Gargoyle Order carved on them.
In 2028, multinational conglomerate OmniCorp revolutionizes warfare with the introduction of robotic peacekeepers capable of maintaining law and order in hot spots such as Iran. Led by CEO Raymond Sellars, the company moves to market its tech to domestic law enforcement, but the passage of the Dreyfus Act, forbidding deployment of drones on U.S. soil, prevents this. Aware that most Americans oppose the use of military systems in their communities, Sellars asks Dr. Dennett Norton and his research team to create an alternative. The result is a proposal for a cyborg police officer. However, Norton informs Sellars that only someone who is stable enough to handle being a cyborg can be turned into one, and some candidates are rejected.