The film opens with George W. Bush (Josh Brolin), dreaming of being a baseball player and is in the stadium with a empty crowd cheering for him. In 1966, Bush endures an alcohol-fueled initiation by his fellow Yale University students as a Delta Kappa Epsilon pledge. During the hazing, Bush successfully recalls the names and nicknames of many of the fraternity members, and states that his family's political legacy is one in which he has no interest. A little later, after Bush is jailed in New Jersey for rowdiness following a football game, his father, George H. W. Bush (James Cromwell), states that he will help Bush, but for the last time. Following his graduation from Yale, Bush takes a job at an oil patch back in his home state of Texas, but he quits after only a few weeks. In 1972, "Junior" reveals his real aspirations in a father-son talk: working in professional baseball, in some capacity. Soon afterwards, Bush is accepted into Harvard Business School with the help of his father. That night after drinking heavily, Bush crashes his car into his family estate and challenges his father to a fistfight. His brother, Jeb (Jason Ritter) intervenes and stops the fight.
Jahangir "George" Khan is a Pakistani Muslim who has lived in England since 1937. He has a wife in Pakistan. He and his second wife Ella, a British Roman Catholic woman of Irish descent, have been married for 25 years and have 7 children together: Nazir, Abdul, Tariq, Maneer, Saleem, Meenah, and Sajid. George and Ella run a popular fish and chips shop in the neighbourhood.
Actress Georgia Hines is being released from a rehab center where she has been undergoing treatment for alcoholism and weight gain. She returns to her Manhattan apartment to begin a new sober life with her supportive friends: Jimmy, an unemployed actor, and Toby, a sophisticated, vain socialite. She pledges to both that she will maintain her sobriety and slowly ease back into theatre work.
Uxbal lives in a shabby apartment in Barcelona with his two young children, Ana and Mateo. He is separated from their mother Marambra, a woman suffering from alcoholism and bipolar disorder. Having grown up an orphan, Uxbal has no family other than his brother Tito, who works in the construction business. Uxbal earns a living by procuring work for illegal immigrants and managing a group of Chinese women producing forged designer goods along with the African street vendors who are selling them. He is able to talk to the dead and is sometimes paid to pass on messages from the recently deceased at wakes and funerals. When he is diagnosed with terminal prostate cancer leaving him with only a few months to live, his world progressively falls apart.
Set against the backdrop of the Cold War and Soviet political repression of the early 1980s prior to perestroika, Vladimir Ivanoff (Robin Williams), a saxophonist with the Moscow circus, lives in a crowded apartment with his extended family. He stands in lines for hours to buy toilet paper and shoes. When the apparatchik assigned to the circus (Kramarov as Boris) criticizes Vladimir for being late to rehearsal and suggests Vladimir may miss the approaching trip to New York, Vladimir gives Boris a pair of shoes from the queue that made Vladimir late.
Roy Munson, a bowling prodigy, wins the 1979 Iowa state amateur championship and plans to leave his tiny (fictional) hometown of Ocelot, Iowa, to go on the Professional Bowlers Tour. He wins his first tournament, defeating an established pro named Ernie McCracken. Soon after, McCracken convinces Roy to help him hustle some bowlers. The con goes badly with McCracken fleeing and letting Roy take the fall when the bowlers mutilate Roy's hand in revenge.
Paul Kemp (Johnny Depp) is an author who hasn't been able to sell a book. He gets a job at a newspaper in San Juan, Puerto Rico. There, he meets Sala (Michael Rispoli), who gets him acclimatised and tells him he thinks the newspaper will fold soon. Kemp checks into a hotel and while idling about on a boat in the sea, meets Chenault (Amber Heard), who is skinny-dipping while avoiding a Union Carbide party. Kemp is immediately smitten with her.
U.S. Marine Tommy Riordan visits his father, Paddy Conlon (Nick Nolte), a recovering alcoholic who has returned to his Catholic faith. Tommy had to run away from Paddy with his dying mother when he was just a boy due to Paddy having previously been an abusive alcoholic, and has never quite forgiven him. Paddy tries to convince him that he has changed, but to no avail. The next day, Tommy enters a gym where he beats a professional fighter named Pete "Mad Dog" Grimes (Erik Apple) unconscious in less than 30 seconds, in a fight which is filmed via a cell phone's video camera and later uploaded to the Internet, where it goes viral. Tommy learns about a winner-takes-all mixed martial arts tournament called Sparta in which the winner will receive $5,000,000. Tommy asks his father to help him train for the tournament, but only under the condition that Paddy does not try to reconcile their relationship.
Set in Paris in the 1960s, the film is a social comedy that pits the propriety of a well-to-do French family with the earthiness and humour of Spanish cleaning ladies who work in their apartment building. It follows Monsieur Joubert (Fabrice Luchini), an unadventurous stockbroker, as he befriends the Spanish maids who live on the top floor of his building. Maria (Natalia Verbeke), his new maid, introduces him to her compatriots and their simple but happy lives animated by friendship and folklore, in contrast to the relative emotional austerity of his own life. Slowly he recovers his joie de vivre by tasting life's simple pleasures; when his wife (Sandrine Kiberlain) falsely accuses him of having an affair he moves into an empty room in the servants' quarters upstairs, the first time he has had a bedroom of his own.
Elliot is in a hospital, discussing funeral arrangements over the phone. His wife died in an accident. His colleague/friend Rick arrives, Elliot tells him what happened, and Rick tries to offer him support. Elliot goes home alone and drinks himself to sleep. Next morning, he hides the liquor bottle as his granddaughter Eloise, who is bi-racial, knocks on the door and asks where her grandmother is. He tells her he will take her to school and to finish getting ready. He sees visions of his wife and attempts to brush Eloise’s hair, but is unsuccessful. She is upbeat as usual, and they are having difficulty as Elliot tries to do her hair, get her ready, and then take her to school. Elliot admits that he has never driven his granddaughter to school before, and that he got lost.
The film begins with Beau (Hedlund), singing with Kelly (Paltrow), a recovering alcoholic going through rehab. Beau is clearly smitten by her, and it is later revealed that the two have been having an affair, even though Kelly is married to James (McGraw). Kelly is checked out of rehab a month early by James, who wants her to go on a three-city tour to restore her image. She agrees on the condition that Beau becomes her opening act, but James has already made plans to see Chiles Stanton (Meester), a beauty queen with potential to become a rising singer, perform that night in hopes that she will be Kelly's opener instead.
Benjy Stone (Mark Linn-Baker), the narrator, tells of the summer (in his "favorite year" of 1954) he met his idol, swashbuckling actor Allan Swann (Peter O'Toole). In the early days of television, Benjy works as a junior comedy writer for a variety show starring Stan "King" Kaiser (Joseph Bologna). As a special upcoming guest, they get the still famous (though largely washed-up) Swann. However, when he shows up, they realize that he is a roaring drunk. Kaiser is ready to dump him, until Benjy intervenes and promises to keep him sober during the week leading up to the show.
Walter Vale (Richard Jenkins) is a widowed Connecticut College economics professor who lives a fairly solitary existence. He fills his days by sometimes taking piano lessons in an effort to emulate his late wife, a classical concert pianist, and infrequently works on a new book. When he is asked to present a paper at an academic conference at New York University, he is not enthusiastic to make the trip, given he is only the nominal co-author and has never even read the complete work. Charles (Michael Cumpsty), his department head, insists and Walter is forced to attend.
Tom Hepple, a geologist, and Gerri Hepple, a counsellor, are an older married couple who have a comfortable, loving relationship. The film observes them over the course of the four seasons of a year, surrounded by family and friends who mostly suffer some degree of unhappiness. Gerri's friend and colleague, Mary, works as a receptionist at the health centre. She is a middle-aged divorcee seeking a new relationship, and despite telling everyone she is happy, appears desperate and depressed. She often seems to drink too much. The Hepples' only child, Joe, is 30 and unmarried and works as a solicitor giving advice on housing.
Late one night, a drunken Brick Pollitt (Paul Newman) is out trying to recapture his glory days of high school sports by leaping hurdles on a track field, dreaming about his moments as a youthful athlete. Unexpectedly, he falls and breaks his leg, leaving him dependent on a crutch. Brick, along with his wife, Maggie "the Cat" (Elizabeth Taylor), are seen the next day visiting his family's estate in Mississippi, there to celebrate Big Daddy's (Burl Ives) 65th birthday.