As a young boy, Noah witnesses his father, Lamech, killed by a young Tubal-cain. Many years later an adult Noah is living with his wife Naameh and their sons Shem, Ham, and Japheth. After seeing a flower grow instantly from the ground and being haunted by dreams of a great flood, Noah takes them to visit his grandfather Methuselah.
God and Lucifer are engaged in a war for the souls of humanity; a standing wager for the souls of all mankind. Angels and demons are forbidden to manifest on Earth, but they are allowed to possess and influence humans, and half-breeds are used to peddle influence. Exorcist John Constantine was born with the power to see angels and demons. At age 15, he committed suicide to escape his visions, but he was revived after spending two minutes in Hell, and his soul is bound for Hell when he dies for the sin of taking his own life.
Seth (Nicolas Cage) is one of many angels who watch over humans and protect them in unseen ways. Seth's main responsibility is to appear to those who are close to death and guide them to the next life. As part of this task, Seth and one of his fellow angels, Cassiel (Andre Braugher), like to ask people what their favorite thing in life was. Despite these daily encounters, they have trouble understanding human beings and their ways.
Billionaire media mogul William "Bill" Parrish is considering a merger between his company and another media giant, while also about to celebrate his 65th birthday with an elaborate party being planned by his eldest daughter Allison. He begins to hear mysterious voices, which he tries with increasing difficulty to ignore. His youngest daughter Susan, an internal medicine resident, is involved with one of Bill's board members, Drew. She is considering marriage, but her father can tell she's not passionately in love. When she asks for the short version of his impassioned speech, he simply says, "Stay open.
Vartan Malt (Bob Hoskins) is the editor of a tabloid called the National Mirror that specializes in unlikely stories about celebrities and frankly unbelievable tales about ordinary folkspersons. When Malt gets word that a woman is supposedly harboring an angel in a small town in Iowa, he figures that this might be up the Mirror's alley, so he sends out three people to get the story – Frank Quinlan (William Hurt), a reporter whose career has hit the skids; Huey Driscoll (Robert Pastorelli), a photographer on the verge of losing his job (even though he owns the Mirror's mascot Sparky the Wonder Dog); and Dorothy Winters (Andie MacDowell), a self-styled "angel expert" (actually a dog trainer hired by Malt to eventually replace Driscoll).
Après la tragique disparition de sa fille, Mack Philipps, père de trois enfants, est rongé par la tristesse et la culpabilité, niant l'existence de Dieu. Un jour, il reçoit une mystérieuse invitation le conviant à un week-end sur les lieux du crime, une cabane abandonnée où sa fille a été retrouvée assassinée. Intrigué, il s’y rend et rencontre trois personnages. De reproches en échanges, il va découvrir qui sont vraiment Dieu, Jésus et le Saint-Esprit. Cette rencontre va non seulement lui permettre de guérir sa souffrance, mais également le réconcilier avec lui-même et avec Dieu.
New York City teenager Clary Fray begins seeing a strange symbol, worrying her mother Jocelyn Fray and her mother's friend Luke Garroway. Later, at a nightclub with her friend, Simon Lewis, Clary is the only person who sees Jace Wayland killing a man. Meanwhile, Jocelyn is abducted by two men, Emil Pangborn and Samuel Blackwell, but she is able to call Clary and warn her about someone named Valentine. Jocelyn drinks a potion putting her in a comatose state. Returning home, Clary finds her mother missing and is then attacked by a demon. Jace appears and kills it. Jace explains that he and her mother Jocelyn are both Shadowhunters (also called Nephilim), warriors that slay demons and rule over the downworlders. Clary has inherited her powers, including the ability to use runes.
Pete Sandich (Dreyfuss) is an aerial firefighter, flying a war-surplus A-26 bomber dropping fire retardant slurry to put out forest wildfires. His excessive risk taking in the air deeply troubles his girlfriend, Dorinda Durston (Hunter), a pilot who doubles as a dispatcher, and is also of concern to his best friend, Al Yackey (Goodman), a fellow fighter. On one flight, Pete makes one extra drop, runs out of fuel, and barely manages to glide onto the runway.
The Archangel Michael (Paul Bettany) falls to Earth in Los Angeles and cuts off his wings. He steals a police car after a policeman is killed by another officer who is possessed. He travels towards the Paradise Falls Diner, near the edge of the Mojave Desert. Meanwhile, Kyle (Tyrese Gibson), a single father driving to Los Angeles, stops at the diner. He meets the owner, Bob Hanson (Dennis Quaid); Bob's son, Jeep (Lucas Black); Percy (Charles S. Dutton), the short-order cook; Charlie (Adrianne Palicki), a pregnant waitress; Howard (Jon Tenney) and Sandra (Kate Walsh) Anderson, a married couple; and Audrey (Willa Holland), their rebellious teenage daughter. An old woman (Jeanette Miller) enters the diner and begins taunting the diner's patrons. When Howard confronts her, she rips his throat open, screeches that they are all going to die, and climbs up the ceiling. Kyle shoots her before she can kill Jeep. Percy, Kyle, Sandra, Audrey and Charlie try to get Howard to the hospital but they are forced to turn back after passing through a swarm of flies.
The story revolves around a struggle to determine which of Satan's (Harvey Keitel) three sons will succeed their father as ruler of Hell. Adrian (Rhys Ifans) is the most devious, Cassius (Tom Lister Jr.) is the cruelest, and Nicky (Adam Sandler) is their father's favourite. Adrian and Cassius claim that Nicky's mother is a goat and torment him by controlling his body with their minds. Nicky has had a speech impediment and a disfigured jaw since Cassius hit him in the face with a shovel.
Joe Gideon is a theater director and choreographer trying to balance work on his latest Broadway musical with editing a Hollywood film he has directed. He is a workaholic who chain-smokes cigarettes, and without a daily dose of Vivaldi, Visine, Alka-Seltzer, Dexedrine, and sex, he wouldn't have the energy to keep up the biggest "show" of all — his life. His girlfriend Katie Jagger, his ex-wife Audrey Paris, and daughter Michelle try to pull him back from the brink, but it is too late for his exhausted body and stress-ravaged heart. In his imagination, he flirts with an angel of death named Angelique.
Bartleby (Affleck) and Loki (Damon) are fallen angels, banished for eternity from Heaven to Wisconsin for insubordination after an inebriated Loki (with Bartleby's encouragement) resigned as the Angel of Death. When the trendy Cardinal Glick (Carlin) announces that he is rededicating his cathedral in Red Bank, New Jersey in the image of the "Buddy Christ", the angels see their salvation: Anyone entering the cathedral during the rededication festivities will receive a plenary indulgence; all punishment for sin will be remitted, permitting direct entry into Heaven. They receive encouragement from an unexpected source: Azrael (Lee), a demon, once a Muse, also banished from Heaven (for refusing to take sides in the battle between God and Lucifer); and the Stygian Triplets (Barret Hackney, Jared Pfennigwerth, and Kitao Sakurai), three teenage hoodlums who serve Azrael in Hell.