Taking place in a Manhattan apartment building, Max's life as a favorite pet is turned upside down when his owner Katie brings home a sloppy mongrel named Duke, who was rescued from the pound. Little do they know, they have to put their quarrels behind when an adorable white rabbit named Snowball, the leader of an army of abandoned pets – called the "Flushed Pets" – is determined to take revenge on all happily-owned pets and their owners.
Carl Fredricksen is a young 8-year-old boy who idolizes famous explorer Charles Muntz. Muntz has been accused of fabricating the skeleton of a giant exotic bird he says he discovered at Paradise Falls, and vows to return there to catch one alive. One day Carl befriends a girl named Ellie, who is also a fan of Muntz. She confides to Carl her desire to move her "clubhouse"—an abandoned house in the neighborhood—to a cliff overlooking Paradise Falls. Carl and Ellie eventually get married and live together in the restored house. After suffering a miscarriage and being told they cannot have another child, the two decide to realize their dream of visiting Paradise Falls. They try to save for the trip, but repeatedly end up spending the money on more pressing needs. Finally, an elderly Carl arranges for the trip, but Ellie suddenly becomes ill and dies.
In Scotland, Merida, a young princess of the clan Dunbroch, is given a bow and arrows by her father, King Fergus, for her birthday. Her mother, Queen Elinor, is dismayed. While venturing into the woods to fetch a stray arrow, Merida encounters a will-o'-the-wisp. Soon afterwards, Mor'du, a huge demon-bear, attacks the family. Merida flees on horseback with Elinor, while Fergus fights off Mor'du at the cost of his left leg.
In Brazil, various exotic birds are smuggled out of the country. In Moose Lake, Minnesota, a crate with a male Spix's macaw hatchling falls out of a truck and is found by a little girl named Linda Gunderson, who names him Blu. Over the next 15 years, Linda owns a bookstore. Highly domesticated and unable to fly, Blu is ridiculed frequently by the Canada geese that come by outside of Linda's bookstore.
Blue macaws Blu and Jewel, and their three children, are living happily in the city until Jewel realises that her children are becoming more like humans. Meanwhile, Blu's former owner, Linda Gunderson and her ornithologist husband, Tulio are on an expedition in the Amazon and eventually discover a quick-flying spix's macaw that loses one of its feathers. When word gets out about this through television, Jewel believes that they should go to the Amazon to help find the blue macaws. While the kids are ecstatic, Blu is uncertain, but is pressured into going along. Rafael, Nico and Pedro decide to come along. Luiz attempts to follow, but fails. Blu brings a fanny pack full of supplies, one of which he uses mostly is a GPS, much to Jewel's displeasure.
A saber-toothed squirrel (known as Scrat) is trying to find a place to store his prized acorn. Eventually, as he tries to stomp it into the ground, he causes a large crack in the ground that extends for miles and miles and sets off a large avalanche. He barely escapes, but finds himself stepped on by a herd of prehistoric animals. The animals are trying to avoid the ice age by migrating south. Sid, a clumsy ground sloth left behind by his family, decides to move on by himself but is attacked by two Brontops whom he angered. Sid is soon saved by Manfred ("Manny"), an agitated mammoth who fights them off and is heading north. Not wanting to be alone and unprotected, Sid follows Manny. Meanwhile, Soto, the leader of a Smilodon pride, wants revenge on a group of humans by eating the chief's baby son, Roshan, alive. Soto leads a raid on the human camp, during which Roshan's mother is separated from the rest and jumps down a waterfall when cornered by Soto's lieutenant, Diego. For his failure, Diego is sent to find and retrieve the baby.
In a world where toys pretend to be lifeless in the presence of humans, Woody, a pullstring cowboy toy, is the leader of a group of toys that are owned by a boy named Andy Davis. With his family moving away one week before his birthday, Andy is given a week-early party to spend with his friends, while the toys stage a reconnaissance mission to discover Andy's new presents. Andy receives a spaceman action figure named Buzz Lightyear, whose impressive features see him replacing Woody as Andy's favorite toy. Woody becomes resentful, especially when he notices that Buzz also gets attention from the other toys. However, Buzz believes himself to be a real space ranger on a mission to return to his home planet, while Woody tries to convince him that he is just a toy.
Young journalist Tintin and his dog Snowy are browsing in an outdoor market in Brussels, Belgium. Tintin buys a miniature model of a ship, the Unicorn, but is then accosted by Barnaby and Ivan Ivanovitch Sakharine, who both unsuccessfully try to buy the model from Tintin. Tintin takes the ship home, but it is accidentally broken, resulting in a parchment scroll slipping out of the model and rolling under a piece of furniture. Meanwhile, detectives Thomson and Thompson are on the trail of a pickpocket, Aristides Silk. Tintin, later finds that the Unicorn has been stolen. He then visits Sakharine in Marlinspike Hall and accuses him of the theft when he sees a miniature model of the Unicorn, but when he notices that Sakharine's model is not broken, he realizes that there are two Unicorn models. Once Tintin returns home, Snowy shows him the scroll. Moments later, Barnaby arrives at Tintin's residence, but is fatally shot and killed. After reading an old message written on it, Tintin puts the scroll in his wallet, but it is stolen by Silk the next morning.
Stanley Ipkiss is a shy and unlucky bank clerk working at the local Edge City bank. He is frequently picked on by everyone around him like the Bank President's son Mr. Dickey, his ruthless landlady Mrs. Peenman, and the mechanics Irv and Burt Ripley who ripped him off. The only exception of this is his Jack Russell Terrier Milo and his co-worker and best friend Charlie Schumaker. Meanwhile, gangster Dorian Tyrell operates a nightclub called the Coco Bongo while plotting to overthrow his boss Niko. One day, Tyrell sends his singer girlfriend Tina Carlyle into Stanley's bank to record its layout, in preparation to rob the bank.
In 1607, the Susan Constant sails to the New World from England, carrying British settlers of the Virginia Company. On board are Captain John Smith and the voyage's leader Governor Ratcliffe, who seeks large amounts of gold in the New World to assure a strong position at the British court. Along the way, the Susan Constant is caught in a North Atlantic storm, and Smith saves a young, inexperienced crewmate named Thomas from drowning. In the Powhatan tribe in the New World, Pocahontas, daughter of Chief Powhatan, dreads being possibly wed to Kocoum, a brave warrior whom she sees as too "serious" for her free-spirited personality. Chief Powhatan gives Pocahontas her deceased mother's necklace as a present. Pocahontas, along with her friends, the gluttonous raccoon Meeko and hot-tempered hummingbird Flit, visit Grandmother Willow, a spiritual talking willow tree, and speaks of a possibly prophetic dream involving a spinning arrow, and her confusion regarding what her "path" in life should be. Grandmother Willow then alerts Pocahontas to the arriving British.
While scavenging for food, RJ the raccoon enters the cave of Vincent the bear who has a large wagon full of human food taken from a nearby rest stop. RJ accidentally wakes Vincent from his hibernation, and in a race to escape, causes the stash to roll out onto the nearby highway and get run over. To avoid being eaten himself, RJ promises Vincent that he will completely replace the stash within the week.
American video game designer Roger Dearly (Jeff Daniels) lives with his pet dalmatian, Pongo, in London. One day, he takes Pongo for a walk in St. James's Park, and he sets his eyes on a beautiful female dalmatian named Perdita. After a frantic chase through the streets of London, Roger and Pongo discover that Perdita likes Pongo; and her owner, Anita Campbell-Green (Joely Richardson), falls in love with Roger when they meet. After they both end up falling into the lake as a result of their dogs, they return to Roger's home, and Anita accepts his proposal to wed. They get married along with Perdita and Pongo.
A dog named Bolt (John Travolta) and a girl named Penny (Miley Cyrus) star on a hit television series called Bolt in which the titular character has various superpowers and must constantly thwart the evil plans of the nefarious Doctor Calico (Malcolm McDowell). To gain a more realistic performance, the TV show's producers have deceived Bolt his entire life, arranging the filming in such a way that Bolt believes the television show is real and he really has superpowers, including a powerful sonic scream-like "superbark". Mistakenly believing Penny has been kidnapped by the villain, Bolt escapes from his on-set trailer in Hollywood but falls into a box of foam peanuts and unknown to the film company is accidentally shipped to New York City. In New York, Bolt starts to notice that his "superpowers" aren't working, and rationalizes this is the effect that styrofoam has on his body. He then meets Mittens (Susie Essman), a female alley cat who bullies pigeons out of their food. Bolt forces Mittens to help him get back to Hollywood, and after Bolt knocks Mittens unconscious the two start their journey westward on a truck. In Hollywood, Penny is deeply saddened over Bolt's disappearance but is convinced by the studio to continue filming with a Bolt lookalike.
In a warehouse, the Mystery, Inc. gang illustrates a plan to catch the Luna Ghost who has kidnapped Daphne Blake (Sarah Michelle Gellar), flying around with her bound and gagged which goes astray but ends with Shaggy Rogers (Matthew Lillard) and Scooby-Doo (voiced by Neil Fanning) causing the Ghost to be caught. The gang unmasks the Luna Ghost, who is revealed the janitor of the Wow-O-Toy Factory, Old Man Smithers, who wanted revenge after Pamela Anderson refused to go out with him (it is implied that he kidnapped Daphne, mistaking her for Pamela). After solving the mystery, constant arguments among the members of Mystery Incorporated about Fred Jones (Freddie Prinze, Jr.) taking credit for Velma Dinkley's (Linda Cardellini) ideas and Daphne always getting kidnapped cause the gang to go their separate ways, much to the dismay of Shaggy and Scooby.