A group of animal activists, consisting of Dr. Nikki Riley (Debbie Gibson), Gia (Arden Cho) and Ben (Patrick Hancock), break into a house and steal dozens of exotic pythons before setting them free into the Florida Everglades. Their actions inadvertently cause the snakes to grow into alarming sizes and threaten the ecosystem, as they kill over 72 alligators in a matter of days. Due to the threat of the invasive species, Park Ranger Terry O’Hara (Tiffany) issues permits to the local hunters to exterminate the pythons – much to Nikki’s dismay. However, the hunters themselves – including Terry’s fiancé Justin (Carey Van Dyke) – are quickly eliminated by the giant snakes. Vowing to avenge her fiancé’s death, Terry and Angie (Kathryn Joosten) take boxes of anabolic steroids from Angie’s grandson Manny (Chris Neville) and inject them into dead chickens before feeding them to alligators. Among the steroids is an experimental serum that neutralizes muscle growth inhibitors with a side effect of increased aggression. Meanwhile, Nikki and her group set up cameras all over the Everglades to monitor Terry’s activities. They catch and record Terry and Angie feeding the steroid-laced chickens to the alligators.
When two young boys are savagely attacked and killed by a legion of rattlesnakes in a small California desert town, the local sheriff (Tony Ballen) calls upon herpetologist Dr. Tom Parkinson (Sam Chew), a Los Angeles college professor, to discover why the snakes are displaying abnormal aggression and swarming behavior. The sheriff teams Parkinson with war photographer Ann Bradley (Elisabeth Chauvet).
A genetics laboratory run by Dr. Irwin Burns (Joseph Ruskin) to research aggressive behavior has an accident, resulting in a chemical fire and explosion, and the escape of a thirty foot long hybrid snake with traits of both the Asian King Cobra (in the film, it is referred to as the African King Cobra, even though the King Cobra species doesn't inhabit the African Subcontinent) and the Eastern Diamondback Rattlesnake. Loose in the countryside and filled with the experimental aggressiveness drug, the snake, nicknamed "Seth", eventually outgrows his woodland prey, it begins hunting the residents of the small brewery town of Filmore.
The crew of a plane gets nervous when the cargo it is carrying starts making noises and shifting. When one of the crew opens the crate, the pilot hears screams from the back. Something attacks him, causing the plane to crash near a town called Ruby. The cargo survives the crash and begins attacking Ruby citizens, starting with a lesbian couple camping in the woods.
Neang Nhi (Ampor Tevi), a woman neglected by her abusive husband, Manop, is working in the fields one day when she accidentally loses her hoe in some shrubbery and encounters a giant python. The snake speaks to Nhi, and says he will return her hoe if she agrees to have sex with him. That night, the snake transforms into a man (Tep Rindaro), brings back the hoe, and has sex with Nhi, a union that results in Nhi's pregnancy.
In 1991, a group of Iraqi commandos penetrates a secret American government lab, releasing genetically modified rattlesnakes. Over the following years, the snakes breed and multiply. In the present days, an earthquake drives them from the underground to the surface, and the snakes infect whoever they bite with a fatal virus. A small-town doctor tries to correct the situation, but the government wants to hide the traces of its wrongdoings.
Paleontologist Robert Trenton (Dean Cain) is called to Northeastern Antarctica near the Indian Ocean to help the FBI build an underground maximum-security military base and prison for the world's most dangerous criminals and terrorists. The prison is dubbed "New Alcatraz" by the staff. While building the prison, the staff accidentally awaken and unleash a prehistoric Boa Constrictor from its 200 million year hibernation. The snake escapes unnoticed until the staff notice a massive hole chewed in the five-foot thick concrete walls. Soon, the staff, and prisoners begin disappearing as they are brutally hunted and eaten by the snake. The FBI agents, Trenton and the rest of the prisoners try to escape, but are hampered as they don't have many weapons. They begin to give up hope as most of the survivors die. However, Trenton manages to kill the snake by kicking it off the helicopter, which it had bitten into, and it is assumed the fall kills the snake.
The sequel to The Snake King's Child, after Vaha and Soriya married, they gave birth to a boy and named him, Mek. However, Vaha, then, married another woman and gave birth to another boy named Sok but the new wife got jealous to Soriya and stole her ring. Suddenly Soriya turned to the snake and Vaha dropped dead by a heart attack. The new wife took everything and blamed Mek as the servant.
Although taking the same basic idea from Snakes on a Plane (lots of deadly snakes loose on a claustrophobic, high speed means of transport), the background story of how the snakes end up on the train is completely different.
There is a secret lab where scientifically enhanced snakes are bred for their venoms—used to treat various diseases. One day, the snakes escape the lab and slither on over to nearby Eden Island, a secluded land of fishing tourism. The homeland security is notified and plans an air strike.
In Romania, a female anaconda and a male anaconda captured, are being held in a genetic research facility, Wexel Hall for experimentation. The research project is led by Dr. Amanda Hayes (Crystal Allen) and funded by J.D. Murdoch (John Rhys-Davies), a well-known industrialist. While visiting the facility, Murdoch agitates the male anaconda with a large flashlight, and has it gassed to calm it down. However, as Murdoch, his assistant Pinkus (Ryan McCluskey) and a scientist leave, the anaconda breaks through his enclosure's wall. As it escapes, it kills many of the people working in the lab, though Cupboard escapes the destruction. In looking through the facility, Amanda and another researcher realize that the second (Queen) anaconda has also escaped. Murdoch calls in a team of animal hunters, led by Hammett (David Hasselhoff), to capture both snakes. Amanda and Pinkus go with them. At a small farm in the middle of the woods, the owner is eaten alive by one of the snakes.
The film begins with an outlaw named Wild Bill (Brad Johnson) riding onto an apparent battlefield, he finds an elderly Mexican who asked him "what happened" in Spanish "Qué pasa aqui?" he replies, "La Serpienta Del Diablo." Bill then walks to a carriage, a woman falls out, a copperhead slithers out, and Bill shoots it with his gun. He then rides away.
A baby anaconda, which was captured at the end of the previous film, is being used for experiments by a man named Peter Reysner from the previous film. Peter creates a hybrid of the blood orchids from Borneo that enabled the anaconda to grow so large and live so long, and creates a serum for cell regeneration. After the test seemingly work for the baby anaconda to regenerate, Peter burns it. When he disappears, the long anaconda escapes from the cage and kills Peter in a mine filled with blood orchids. J.D. Murdoch, a billionaire suffering from bone cancer, sends his assassin Eugene and his team of henchmen mercenaries to find Peter and the serum of Peter created it that can cure him. He also tells them to be careful of Dr. Amanda Hayes, and to kill her if needed. As Dr. Amanda Hayes, the sole survivor of the previous snake attack, and two officers also go in search of Peter, determined to destroy the serum and kill the snake.
According to a myth, when snakes are of certain age, they can assume human form. Thus, the film begins with a male and a female in their human forms, singing and dancing amorously with each other. When the male turns back into a snake, he is shot by a member of a hunting party, who thought the snake was going to attack the woman. The rest of the story deals with the female taking revenge on the group of friends responsible for her lover's death. In the end, Vijay is the only one alive and the nagin dies before killing him and realizes that she was wrong and that her revenge destroyed many lives just like her own life was destroyed. Near death, she sees her beloved in the sky calling out to her. She dies and reunites with him in heaven.
After being dumped by his girlfriend Eva, who was tired of his constant negative and sexist attitude, Gene decides to take revenge killing her through a mamba, a poisonous snake, to which he also injected hormones to increase its aggressiveness.