Over the two years since the death of Deacon Frost, Blade (Wesley Snipes), the Daywalker, a vampire unaffected by sunlight and who chooses to defend humans and fight other vampires, has been trying to find his mentor Whistler (Kris Kristofferson), who survived his suicide attempt in the first crisis. Blade has been sweeping across Russia and eastern Europe, enlisting the aid of a young man, Scud (Norman Reedus), to design him a new line of gadgetry and weaponry. Blade carves his way through a large gang of vampires, sparing one, Rush (Santiago Segura), when he promises to reveal Whistler's location. Blade tells Rush he will be back for him. Blade finds Whistler locked in a tank by a gang of vampires who were keeping him alive to torture. Blade rescues Whistler and brings him back to the lair, ridding the latter's vampirism with a cure developed by Dr. Karen Jenson.
A group of vampires look for the hidden resting place of Drake, also known as Dracula—the genetic "father" of their species. They find him in a Syrian ziggurat tomb, although not before, in a moment of blood lust, he kills one of them. The vampires capitalize on Blade's reputation as a serial killer and frame him for the killing of a familiar. During the ensuing manhunt, the FBI locate Blade's latest hideout, and, during the siege, Abraham Whistler dies. With his mentor gone and surrounded by human authorities, Blade allows himself to be captured and arrested.
In an unnamed city, a young Japanese professional (Yusuke Iseya) is suddenly struck blind for no apparent reason. The Japanese man is approached by a few concerned people, one of whom (Don McKellar) offers to drive him home, and later steals his car. The blinded man describes his sudden affliction: an expanse of dazzling white, as though he is "swimming in milk".
In 1936, a German professor, Richard Wirth, is hosted by the Wollners, a family of German emigrants in West Virginia. The Wollners believe him to be a visiting scholar, but Wirth turns out to be a Nazi occultist who seeks a Viking runestone buried on their property. When Wirth reveals he wants to use it for evil, he is interrupted by the family, who trap him in their basement and bind him through a ritual that requires frequent human sacrifices. Linked to Wirth, the family survive through the decades, operating as both captors and servants to Wirth, who they keep weakened.
Billions of people are killed in World War III, and most of the surviving males are rendered sterile. As a result, humanity resorts to cloning as its primary form of reproduction. All goes well until the first generation of clones turn nineteen and degenerate into bestial killers. The military attempts to contain the threat, but they are unsuccessful. Three groups of survivors who have fled into rural Florida are besieged by the killer clones. Ultimately, Jesse is the last to survive, and the film ends as he is surrounded.
Alex McNetti (Rich George) has a rare disease which gives him very brittle bones. His friend Thomas Granger (Brian Paulin) believes that he has found the cure by feeding his friend dead flesh to counteract the terrible disease. However the process does have its side effects including making Alex cough up and vomit worms, and also turning him into a zombie. The dead start to rise from their graves and butcher every living human they see to pieces, including a heavily armed SWAT team. The zombies later invade a populated city, killing every living person in sight once again.
While working in the church, Grace finds a hidden crypt. While exploring she discovers a voodoo book, however she is soon sent away by Father Cornelius. Grace's son, Nathan attends the local high school, with his friends Henry and Diggs. Nathan likes his long-time friend Jessica however is too scared to ask her out, in case he is rejected. Also in the school are popular girls Charlotte, Glenda and Cheryl. Cheryl pursues Nathan, despite already having a boyfriend, Samson, who confronts Nathan along with his womanising friend Kenneth after seeing Cheryl talking to Nathan. Meanwhile, Henry and Diggs, fed up with Nathan not asking out Jessica, force the pair to meet after school.
A college professor, Dr. Douglas Newton, develops an experimental drug named Tryptophan (not to be confused with real Tryptophan) that has the side effect of turning his students into bloodthirsty zombie-like creatures, leading them to eventually explode. It is up to a couple of grad students, Jenny Wayne and Joe Larsen, along with the local newspaper reporter Ray Elsworth, to uncover Dr. Newton's dark secret and thwart his plans before time runs out.
When a meteor strikes a man on the head, alien slugs take over his brain and turn him into ravenous zombie. As a group of sorority sisters, born-again Christians, and escaped convicts converge in the remote area where he lives, he attacks them all.
In 1957, The "Sumatran Rat-Monkey" is a hybrid creature that, "according to legend", resulted from the rape of tree monkeys on Skull Island by plague-carrying rats. Stewart McAlden (Bill Ralston), an explorer returning from the depths of the island with his team, is carrying a rat-monkey in a cage and is stopped by fierce warrior natives that demand the return of the monkey. They escape to a waiting jeep, but Stewart gets bitten by the Rat-Monkey. Seeing the mark of the monkey's bite on his right hand, Stewart's men hold down the explorer and amputate it. A bite mark is then seen on his left arm, which results in the removal of that limb. Finally, they see a set of bloody scratches on Stewart's forehead and kill him. The captured rat-monkey is shipped to Wellington Zoo in New Zealand.
The movie centers on three high school students whose world is turned upside down by tainted moonshine which turns everyone who drinks it into a flesh eating zombie. It does not take long for the whole town to be overrun.
When their originally planned outing is cancelled, four friends go on a hunting trip in Texas. They include Craig, a straitlaced man; Jerry, a mysterious relative of Craig's from New York; Tom, a nerd; and Lance, a hedonist. When they arrive, they discover that a chupacabra has bitten their guide Clyde, and, unknown to all, he has begun to slowly turn into a zombie. As Clyde shows the friends their cabin, Lance and Candy, Clyde's daughter, make out in the next room. Clyde warns them not to cross onto the property of Billy Ray, a local gangster, and, discovering Lance and Candy, angrily leaves with his daughter. Later that night, Craig reveals that he intends to marry his girlfriend, and Lance behaves strangely; Jerry tells Craig that Lance and Craig's girlfriend have been having an affair, but Craig refuses to believe it.
Max is dating the overbearing Evelyn who he's afraid to break up with. When she's killed in a freak accident, he falls in love with Olivia, with whom he is much better suited. However Evelyn rises from the grave and wants to continue her relationship with Max.
A Manson Family style cult conduct a bizarre Satanic ritual in the woods at night. A member notices a local girl, Sylvia, furtively watching the event. She had befriended a member, Andy, who invited her to watch. The angered group leader Horace Bones leads an assault on the girl.