The film opens in Gethsemane as Jesus prays and is tempted by Satan, while his disciples Peter, James and John (James' brother) sleep. Satan appears in Jesus' form, and tempts him by saying, "It's not right for one man to die for their sins." After Jesus' sweat becomes like blood and drips to the ground, a snake comes out from Satan. Jesus hears his disciples calling him, then he steps on the snake's head, and the Devil disappears. After receiving thirty pieces of silver, Judas, another of Jesus' disciples, approaches with the temple guards and betrays Jesus with a kiss on the cheek. As the guards move in to arrest Jesus, Peter cuts off the ear of Malchus, a servant of the high priest Caiaphas, but Jesus heals the ear. As the disciples flee, the temple guards arrest Jesus and beat him during the journey to the Sanhedrin. John tells Mary and Mary Magdalene of the arrest while Peter follows Jesus at a distance. Caiaphas holds trial over the objection of some of the other priests, who are expelled from the court. When questioned by Caiaphas whether he is the Son of God, Jesus replies "I am". Caiaphas is horrified and tears his robes, and Jesus is condemned to death for blasphemy. Peter, who is secretly watching, is confronted three times and denies three times, but then runs away sobbing after remembering that Jesus had foretold that. Meanwhile, the remorseful Judas attempts to return the money to have Jesus freed, but is refused by the priests. Tormented by Demons, he flees the city and hangs himself upon a tree with a rope he finds on a dead donkey.
Lester Burnham is a middle-aged magazine writer who despises his job. His wife, Carolyn, is an ambitious real estate broker; their sixteen-year-old daughter, Jane, abhors her parents and has low self-esteem. The Burnhams' new neighbors are retired United States Marine Corps Colonel Frank Fitts and his introverted wife, Barbara. Their teenage son, Ricky, obsessively films his surroundings with a camcorder, collecting hundreds of recordings on video tapes in his bedroom. He also secretly deals marijuana, using a job as a part-time bar caterer to help keep it secret from his father. Having been previously forced into a military academy and a psychiatric hospital, Ricky is subjected by Col. Fitts to a strict disciplinarian lifestyle. Jim Olmeyer and Jim Berkley, a gay couple who live nearby, welcome the family to the neighborhood; Col. Fitts later reveals his homophobia when angrily discussing the incident with Ricky.
Four high school seniors from western Michigan are good friends: Jim Levenstein (Jason Biggs), an awkward, nerdy and sexually naïve character whose dad Noah (Eugene Levy) attempts to offer sexual advice including purchasing and giving him pornography; Chris "Oz" Ostreicher (Chris Klein), a member of the high school lacrosse team; Kevin Myers (Thomas Ian Nicholas), their geeky leader who wants to lose his virginity with his girlfriend named Vicky (Tara Reid); and Paul Finch (Eddie Kaye Thomas), a mochaccino-drinking sophisticate and a nerd. They are four outsiders who are geeks, usually get laughed at by arrogant jock Steve Stifler (Seann William Scott). These four boys make a pact, at Kevin's prompting, to lose their virginity before their high school graduation after a dorky classmate, Chuck Sherman (Chris Owen), claims to have done so at a party hosted by Stifler an ignorant and obnoxious lacrosse player who happens to be a close friend of the group (to a lesser degree, Finch, with whom he has a love-hate friendship).
Thirteen years after graduating high school, Jim Levenstein (Jason Biggs), Chris "Oz" Ostreicher (Chris Klein), Kevin Myers (Thomas Ian Nicholas), Paul Finch (Eddie Kaye Thomas), and Steve Stifler (Seann William Scott) are well-established in their lives and careers. Jim is still married to Michelle (Alyson Hannigan) and now has a two-year-old son, Evan. Since the birth of their son, Jim and Michelle's sex life has deteriorated. Oz is an NFL sportscaster living in Los Angeles with his supermodel girlfriend Mia (Katrina Bowden). Kevin is married to Ellie and works from home as an architect. Finch tells his friends that he has been travelling the world, and still searching for his one true love. Stifler works as a temp at an investment firm, where he is also the victim of humiliating verbal abuse by his cold-hearted employer.
Andy Stitzer (Steve Carell) is a 40-year-old virgin who is involuntarily celibate. He lives alone, collects action figures, plays video games, and his social life seems to consist of watching Survivor with his elderly neighbors. He works in the stockroom at an electronics store called SmartTech. When a friend drops out of a poker game, Andy's co-workers David (Paul Rudd), Cal (Seth Rogen), and Jay (Romany Malco) reluctantly invite Andy to join them. At the game (which he wins, due to playing online poker constantly), when conversation turns to past sexual exploits, Andy desperately makes up a story, but when he compares the feel of a woman's breast to a "bag of sand", he is forced to admit his virginity.
In AD 26, Judah Ben-Hur (Charlton Heston) is a wealthy prince and merchant in Jerusalem, who lives with his mother, Miriam (Martha Scott); his sister, Tirzah (Cathy O'Donnell); their loyal slave, Simonides (Sam Jaffe); and his daughter, Esther (Haya Harareet), who loves Ben-Hur but is betrothed to another. His childhood friend, the Roman citizen Messala (Stephen Boyd), is now a tribune. After several years away from Jerusalem, Messala returns as the new commander of the Roman garrison. Messala believes in the glory of Rome and its imperial power, while Ben-Hur is devoted to his faith and the freedom of the Jewish people.
In the year 2019, Lincoln Six Echo and Jordan Two Delta live with others in an isolated compound. Their community is governed by a set of strict rules. The residents believe that the outer world has become too contaminated for human life with the exception of one contagion-free island. Every week a lottery is conducted and the winner gets to leave the compound to live on the island.
A group of Florida high school students plan on losing their virginity. They go to Porky's, a nightclub out in the Everglades, believing that they can hire a prostitute to satisfy their sexual desires. Porky takes their money but humiliates the kids by dumping them in the swamp. When the group demand their money back, the sheriff, who turns out to be Porky's brother, arrives to drive them away, but not before his minions extort the rest of their money and cause them more embarrassment. After Mickey (who returned to Porky's for revenge) is beaten so badly he has to be hospitalized, the gang becomes hellbent on exacting revenge on Porky and his brother, eventually succeeding in sinking his establishment in the swamp. Porky and his men, joined by the sheriff, chase after the group, but they make it across the county line (out of Porky's brother's jurisdiction), where they are met by a group of the local police officers, one of whom is Mickey's older brother Ted, and the high school band. After Ted repeatedly damages Porky's car, he says that all charges against Porky for driving an unsafe vehicle will be dropped if the night's events are forgiven. Because the boys were too young to be legally allowed in Porky's in the first place, Porky and his brother have no choice but to agree. The film ends with the group getting their revenge and Pee Wee finally losing his virginity.
Seth (Jonah Hill) and Evan (Michael Cera) are two high school seniors who lament their virginity and poor social standing. Best friends since childhood, the two are about to go off to different colleges, as Seth didn't get accepted into Dartmouth like Evan. After Seth is paired with Jules (Emma Stone) during Home-Ec class, she invites him to a party at her house later that night. Later, Fogell (Christopher Charles Mintz-Plasse) comes up to the two and reveals his plans to obtain a fake ID during lunch. Seth uses this to his advantage and promises to bring alcohol to Jules' party. Fogell's fake ID is met with derision by Seth and Evan, as it states that Fogell's name is simply "McLovin". After contemplating their options, Seth decides they have no choice but to have Fogell buy the alcohol with his fake ID. Fogell goes in and successfully buys the alcohol, but is interrupted when a robber enters the store, punches him in the face, and takes money from the cash register.
Benjamin Braddock, aged twenty, has earned his bachelor's degree and has returned home to a party celebrating his graduation at his parents' house in Pasadena, California. Benjamin, visibly uncomfortable as his parents deliver accolades and neighborhood friends ask him about his future plans, evades those who try to congratulate him. Mrs. Robinson, the neglected wife of his father's law partner, insists that he drive her home. Benjamin is coerced inside to have a drink and Mrs. Robinson attempts to seduce him. She invites him up to her daughter's bedroom to see her portrait and then reenters the room naked, making it clear that she is available to him. Benjamin initially rebuffs her, but after a few days, he clumsily organizes a tryst at the Taft hotel.
In the 1960s, a young woman nicknamed Babydoll (Emily Browning) is institutionalized by her abusive widowed stepfather (Gerard Plunkett) at the Lennox House for the Mentally Insane after she is blamed for the death of her younger sister. The stepfather bribes Blue Jones (Oscar Isaac), an asylum orderly, into forging the signature of the asylum's psychiatrist, Dr. Vera Gorski (Carla Gugino), to have Babydoll lobotomized so she cannot inform the authorities of the true circumstances leading to her sister's death. During her admission to the institution, Babydoll takes note of four items that she would need to attempt an escape.
Teenage friends Will McKenzie, Simon Cooper, Jay Cartwright, and Neil Sutherland have finished their A-levels and are about to leave Rudge Park Comprehensive, much to the relief of Mr. Gilbert, their sardonic sixth form tutor. Within their final week of school, Jay's grandfather dies, Simon is dumped by his girlfriend Carli D'Amato, and Will's divorced father tells him he has married his much younger mistress. The boys decide to go on holiday together and Neil books them a trip to Malia, Crete.
In an upscale New York City mansion, wealthy and popular Kathryn Merteuil (Gellar) is discussing her prep school with Mrs. Caldwell (Christine Baranski) and Caldwell's daughter Cecile (Selma Blair). Kathryn promises Mrs. Caldwell that she will look out for the sheltered and naive Cecile. Sebastian (Phillippe) enters and Mrs. Caldwell reacts to him coldly and leaves with Cecile. Kathryn reveals that her real intention is to use Cecile to take revenge on Court, her ex-lover, who had dumped her for Cecile. Kathryn asks her step-brother Sebastian to seduce Cecile; he refuses as he is planning to seduce virgin Annette Hargrove (Witherspoon), the daughter of their school's headmaster. Annette is a 'paradigm of chastity and virtue' who recently wrote a published essay about saving herself for marriage and has been temporarily staying with Sebastian's aunt. The two make a wager: If Kathryn wins, she gets Sebastian's vintage Jaguar XK140; if Sebastian wins, Kathryn will have sex with him. It is mentioned that Sebastian keeps a journal detailing his conquests.
Olive Penderghast, a teenage girl living in Ojai, California lies to her best friend Rhiannon Abernathy about going on a date in order to get out of camping with Rhiannon's hippie parents. Instead, she hangs around the house all weekend listening to Natasha Bedingfield's "Pocketful of Sunshine". The following Monday, pressed by Rhiannon, Olive lies about losing her virginity to a college guy. Marianne Bryant, a prissy and strictly religious Christian at their school, overhears her telling the lie and soon it spreads like wildfire. The school's conservative church group run by Marianne decides Olive will be their next project. Olive confides the truth to her friend Brandon, and he explains how others bully him because of his homosexuality. He later asks Olive to pretend to sleep with him so that he will be accepted by everyone.