In 1897, Mrs. Sarah Hargrave, a widow, and two young children (one of whom is the son of the castaways from the original film) are cast off from the ship they are travelling on, because the ship's crew are infected with cholera. After days afloat, Kearney, a sailor who has been sent with them, tries to kill the boy because of his excessive crying. Sarah angrily beats Kearney to death with a harpoon and dumps his body overboard. The trio arrives at and is stranded on a beautiful tropical island in the South Pacific. Sarah tries to raise them to be civilized, but soon gives up, as the orphaned boy Richard was born and raised by young lovers on this same island, and he influences the widow's daughter Lilli. They grow up, and Sarah educates them from the Bible, as well as from her own knowledge, including the facts of life. She cautiously demands the children never to go to the forbidden side of the island.
We see Mary Magdalene, here portrayed as a wild courtesan, entertain many men around her. Upon learning that Judas is with a carpenter she rides out on her chariot drawn by zebras to get him back. Peter is introduced as the Giant apostle, and we see the future gospel writer Mark as a child who is healed by Jesus. Mary, the mother of Jesus, is shown as a beautiful and saintly woman who is a mother to all her son's followers. Our first sight of Jesus is through the eyesight of a little girl, whom He heals. He is surrounded by a halo. Mary Magdelene arrives afterwards and talks to Judas, who reveals that he is only staying with Jesus in hopes of being made a king after Jesus becomes the king of kings. Jesus casts the Seven Deadly Sins out of Mary Magdalene in a multiple exposure sequence.
The film opens during Spring Break on the Upper East Side. White Mike, once a wealthy, carefree teenager, now struggles to scrape out a living as a pot dealer, dealing to his former classmates. His mother died from breast cancer a year prior to the events of the film, her treatment having completely consumed his family's wealth, and left a deep emotional trauma on Mike. Mike's good friend, Molly Norton, a sweet girl from the poorer side of town, doesn't know he is a drug dealer. Mike's supplier, Lionel, also deals the addictive drug cocktail "Twelve" to Mike's cousin, Charlie. Charlie attempts to mug Lionel one night, as he is unable to pay for the drug. Lionel turns the gun on Charlie, shooting him at point blank range, before finding and executing Nana, an innocent observer, returning home after a basketball game at the Harlem Recreation Center. Mike and Charlie's good friend, Hunter, another resident of the wealthy Upper East Side, set on attending Harvard, who had played basketball with—-and got in a fight with—-Nana earlier that evening, is taken into custody for the murders. He visits Harlem regularly because he detests the high society of his classmates.
In the Mississippi Delta, failing, bigoted, middle-aged cotton gin owner Archie Lee Meighan (Karl Malden) has been married to pretty, empty-headed 19-year-old virgin Baby Doll Meighan (Carroll Baker) for two years. Archie impatiently waits for Baby Doll's 20th birthday just a few days away when, by prior agreement with Baby Doll's dying father, the marriage can finally be consummated. In the meantime, Baby Doll still sleeps in a crib, wearing childish shorty-nightgowns and sucking her thumb, while Archie, an alcoholic, spies on her through a hole in a wall of their decrepit antebellum mansion, Fox Tail. Baby Doll's senile Aunt Rose Comfort (Mildred Dunnock) lives in the house as well.
When porn star Roxy Doujor is denied entrance into the afterlife, she is given one last chance to help some poor soul on Earth. She finds Rudy Gerner (whose character was the center of the original film as an adolescent) working at a summer river resort. Roxy is given the task of helping Rudy lose his virginity in order to be allowed into the afterlife.
Four teenagers from late 1950s Los Angeles are on their way to Tijuana, Mexico: Dave, Woody, Spider, and Dave's brother Wendell. Dave, Spider, and Woody are there to lose their virginity, while Wendell came along with them to buy fireworks. They end up picking up a woman named Kathy, who goes with them because she wants a fast divorce from her husband, and they get into a series of misadventures south of the border.
Anaïs (Anaïs Reboux) and her older sister, Elena (Roxane Mesquida) are vacationing with their parents on the French seaside. Bored of staying in their vacation home, the two walk into town while discussing relationships and their virginity. Although the highly attractive Elena has been promiscuous, she is saving herself for someone who loves her, while heavy-set, overweight Anaïs thinks it is better to lose one's virginity to a "nobody" just to get it over with.
The story centers around four gay friends who have recently graduated from San Torum High School. Andy (Michael Carbonaro) is an awkward, sex-crazed character who frequently masturbates with his mother's fruits and vegetables. Jarod (Jonathan Chase) is a handsome and fit jock who is quite insecure. Griff (Mitch Morris) is a nerdy, well-dressed guy who is secretly in love with Jarod. Nico (Jonah Blechman) is the most flamboyant, outgoing, and effeminate of the group. The four of them decide to make a pact to have sex by the end of the summer. Each boy proceeds to pursue sex in different ways, with both tragic and comedic results. Nico tries to secure an online date with a man named Ryder (Matthew Rush), but ends up with Muffler's grandfather (George Marcy). Andy pursues his long-time crush, his math teacher, Mr. Puckov (Graham Norton), but fails; he instead ends up going threesome with Angel (Darryl Stephens), a male stripper, and Beau (James Getzlaff), a baseball pitcher. Jarod seeks out fellow jocks, including Beau, but ends up dumping him in order to have sex with Griff, who tries to earn the affection of Angel; it starts out successfully, but then Griff chooses Jarod as his true love. Much of the humor comes from how awkward each boy is at romance and how naive they are about sex. Each plot backfires horribly, until the boys finally begin to change their attitudes towards sex at the end of the film.
Jack Slavin (Daniel Day-Lewis), a Scottish farmer with a heart illness, lives on an island which had been a hippie commune decades before. He is struggling to keep landowners from building developments on the wetland. His teenaged daughter Rose (Camilla Belle) is a beautiful but isolated girl with a passion for gardening. Since Rose's mother had left the family, Jack homeschooled his daughter and did not expose her to life beyond their small island home. Jack believes that they both "need a woman around." He travels to the mainland to ask his girlfriend Kathleen (Catherine Keener) to move in with him. Jack breaks the news to a shocked Rose, from whom he had kept his relationship a secret. Rose remains disdainful when Kathleen and her two teenage sons move in.
Four male teenage friends in New Orleans, Louisiana: Matt, Zack, Jacob and Justin, buy a bong and agree to use it only to celebrate when one of the four have sex for the first time. The boys are beginning to lose their virginity and Matt is the last one. Matt is the adopted brother of Zack after Matt's mother died from cancer when he was 9. Matt's father had drug issues, and only plays a minor role in his life. Matt has been with his girlfriend Nicole for almost two years and the two decide to lose their virginity together on their second anniversary. Zack decides to videotape the entire process to make his own documentary-type film.
The Flemish boys Lars, Philip and Jozef are somewhere between 20 and 30 years of age and each has a physical handicap. Jozef is almost blind and needs to use a magnifier. Philip suffers from paraplegia. He can only move his head and can use one hand which gives him the strength to control his automated wheelchair. Lars has an incurable brain tumor a side effect of which is that he is restricted to a wheelchair as a result of his increasing paralysis. The three are good friends and visit each other frequently.
Pendant les vacances, Jamie rencontre la belle Juliana qui est de passage dans sa ville et tombe amoureux d'elle. Mais petit à petit, Jamie remarque que depuis l'arrivée de Juliana, plusieurs choses étranges se passent. Un de ses amis disparaît, puis un second et puis un monsieur vient lui annoncer qu'un loup garou circule parmi eux et qu'il est à la recherche de personnes vierges. Depuis, tous les jeunes de la ville cherchent à perdre leur virginité.
Dorri Lawrence (Cook) is an actress and singer who resides in Hollywood, California. She is an undiagnosed schizophrenic, which causes problems in her career. After another concert goes wrong due to her untreated disease, she is finally sent to get help for her schizophrenia.
In what would later become the last 48 hours of his life, Jesus of Nazareth (Jean-Claude La Marre), a Black man, leads a group of 12 disciples to the biblical city of Arimathea to celebrate the Jewish holiday of Passover. The city of Arimathea is governed by the elite Jewish Sanhedrin under the administrative jurisdiction of the Roman Empire who persecute and discriminate against the Jewish population. Growing weary of the popular influence displayed by Jesus, a Jew claiming to be a messiah, the Sanhedrin wish to call an emergency meeting to discuss his growing power and clout. From the Sanhedrin, some of the members find it hard to believe a black man although Jewish, could in fact be the messiah. The members attempt to formulate a plan to capture and interrogate Jesus over his alleged blasphemy. Meanwhile, Jesus with the help of his disciple John (Akiva David), discovers a safe dwelling in Arimathea to consume the Passover meal away from the watchful patrol of Roman soldiers who are also attempting to subdue him over his reputation. Accordingly Mary (Debbi Morgan), the mother of Jesus, comes to believe her son is being individually singled out on motivations based on race. In addition to persecuting Jews in general, the Romans also view Jews who are black in skin color as a more troublesome ramification than just ordinary white Jews.
Deena (Kate Bosworth) and Kim (Krysten Ritter) each bring home a guy one night. Realizing they have no condoms, they go looking around in their house where Deena ultimately finds the last one and Kim has unprotected sex. One year later, Kim is a single mother. She still lives with her two girlfriends, Deena and Laura (Rachel Bilson) while trying to juggle her son named Max. She takes Max to his father Mark (Coiro) but he announces that he is not interested in being a father. Kim brings Max along to work with her one day, as a dog service company assistant to her youth-obsessed boss Francesca (Kristen Johnston). Franchesca reprimands Kim for bringing Max with her and says that she would be fired if she does it again. Kim then takes Max to her grandfather (Seymour Cassel) who is currently living in a retirement home. Meanwhile, Deena tries to finish writing her book in a library and ends up hooking up with a guy. One night, as Kim works as a bouncer in one of Francesca's party, she falls for a guy named Nicolas (Stults) who was with two of his friends, Henri (Kirk) and Sergei (Biggs), attending the party. That night, Francesca finally allows Kim to have a break and meet up with Nicolas who promised to buy her a drink earlier and they spend the night getting to know each other. They quickly form a relationship after Nicolas intently asks Francesca to have Kim take his dog in his house. Kim brings along Max with her yet again where she lies to Nicolas that Max is a child of one of her roommates and that she was just relied on to look after Max. Kim asks Deena to come with her on her date with Nicolas that evening where Deena agrees. Nicholas arrives along with his friend Henri, where they look to Deena as her roommate with the baby. Kim begs Deena to just go with the lie they've come up with where Deena responds that it wouldn't take long enough for them to know that Kim is the one with a baby. They have a double date where it seems that Deena and Henri are attracted to each other, although Henri dresses up in hippie clothing. The next day, Deena seems promoted from her career as a writer when someone could recognize her from an article she wrote. Kim on the other hand, seems to be an underdog as Francesca wouldn't allow to invest in her own dog service business. Laura, the other roommate seems to be unstable as she has been shifting jobs every week. Kim asks her to take care of Max since she has a date with Nicholas that night, but tells her she can't. She then freaks out and calls Deena who isn't answering her calls. Finally, she asks a young boy to babysit Max for her. Nicolas and Kim have sex after their romantic date, but it's not long before Nicolas discovers Kim's secret when milk leaks out of her breasts. This leaves Nicholas upset and Kim leaves. On her way home, she sees a paramedic leave and asks Deena what happened. Kim yells at Deena for not returning home early where Deena strikes back at her saying that Max is her responsibility and there is nothing that could excuse her behavior. Deena and Kim's friendship is compromised. Kim spends all day around the house and finally quits her job telling Francesca she never looked 21. The next day, Kim informs Deena that she has to move out of the house and focus her life on being a mother and as for Deena, her successful career. Kim buys a house and visits Mark who regrets everything he said about not being ready and he wants a shot of being a dad for once. Laura then enters a show competition and seems to be successful. Kim finally reconciles with Deena and Nicolas where they all play pool together.