Four gifted street magicians—J. Daniel "Danny" Atlas, Merritt McKinney, Henley Reeves, and Jack Wilder—are brought together by an unknown benefactor and, one year later, are performing in Las Vegas as "The Four Horsemen," sponsored by insurance magnate Arthur Tressler. For the finale of their first show, they declare they will rob a bank, and invite audience member Étienne Forcier, an account holder at the Crédit Républicain de Paris, to do it. Forcier is apparently teleported to his bank in France, where he activates an air duct that vacuums up the money and showers it onto the Las Vegas crowd. Upon the discovery that the money really is missing from the bank vault, FBI agent Dylan Rhodes is called to investigate the theft and is partnered with Interpol agent Alma Dray. They arrest the Horsemen, but are forced to release them due to lack of evidence.
Stanley Ipkiss is a shy and unlucky bank clerk working at the local Edge City bank. He is frequently picked on by everyone around him like the Bank President's son Mr. Dickey, his ruthless landlady Mrs. Peenman, and the mechanics Irv and Burt Ripley who ripped him off. The only exception of this is his Jack Russell Terrier Milo and his co-worker and best friend Charlie Schumaker. Meanwhile, gangster Dorian Tyrell operates a nightclub called the Coco Bongo while plotting to overthrow his boss Niko. One day, Tyrell sends his singer girlfriend Tina Carlyle into Stanley's bank to record its layout, in preparation to rob the bank.
Benjamin Franklin Gates (Nicolas Cage) is an American historian, amateur cryptologist, and the youngest descendant of a long line of treasure hunters. While his father Patrick Henry Gates (Jon Voight) discourages him from following in the family line, Ben is driven on by a story told by his grandfather, John Adams Gates (Christopher Plummer). According to John, a clue - the phrase "The secret lies with Charlotte" - was entrusted to the family by Charles Carroll of Carrollton in 1832, and would lead to the fabled "national treasure", a wealth of artifacts dating from Ancient Egypt and secretly hidden by the Founding Fathers and the Freemasons during the American Revolutionary War.
Four days after the events of the first film, detective James Carter is on vacation in Hong Kong, visiting his friend, Hong Kong Police Force Chief Inspector Lee, as he was sent along with Lee in saving the life of the Chinese counsel's daughter in Los Angeles. The fun is put on hold when a bomb explodes at the United States Consulate General, killing two undercover U.S. custom agents inside. Inspector Lee is assigned to the case, which becomes personal when it is discovered that it somehow involves Ricky Tan, his late police officer father's former partner. Tan, who was suspected of having a role in Lee's father's death - though the connection was never proven - is now a leader of the Triads. This, however, causes a rift between Lee and Carter, the later who simply wants to enjoy his vacation and not get into any danger.
Three years after the events of the first film, Arthur Tressler's son, Walter (Daniel Radcliffe), seeks to bring "The Four Horsemen" to justice, after his father's imprisonment.
Reuben Tishkoff is conned by Willy Bank, his former business partner, by being forced to sign over the ownership rights of the new hotel-casino they were building together, "The Bank". Reuben suffers a heart attack and becomes bedridden. Daniel Ocean offers Bank a chance to set things right, given his long history in Las Vegas and the fact that he "shook hands with Sinatra," though Bank refuses. To avenge Reuben, he gathers his partners-in-crime and plans to ruin Bank on the opening night of the hotel.
In Moscow, Viktor Chagarin (Sergei Kolesnikov), a high-ranking, but corrupt Russian official, plans on incriminating political prisoner, former billionaire and government whistleblower, Yuri Komarov (Sebastian Koch), without a fair trial when Komarov refuses to hand over a secret file believed to have convicting evidence against Chagarin. In a separate incident, Jack McClane (Jai Courtney) is arrested as a result of an assassination attempt but agrees to testify against Komarov for a shorter sentence. John McClane (Bruce Willis), who has not been in touch with his son for several years, learns of his son's actions and travels to Russia to help. When John finally arrives and approaches the courthouse that holds Komarov on trial, a bomb explosion orchestrated by Chagarin's henchman Alik (Radivoje Bukvić) occurs in the courthouse, and Jack breaks free with Komarov. Seeing his son, John confronts him, but their dispute is cut short when Alik and his men chase them in a US Cougar MRAP on the streets of Moscow. John, Jack and Komarov manage to escape.
Debbie (Sandra Bullock), la sœur de Daniel Ocean qui vient de mourir, sort de prison après cinq ans de détention. Elle a passé tout ce temps à préparer un projet particulièrement ambitieux : il s'agit de dérober le Toussaint, un collier de diamants de Cartier estimé à 150 millions de dollars, lors du gala au Metropolitan Museum of Art de New York, qui est organisé dans le cadre d'une exposition de bijoux royaux.
As a child, Colin Sullivan (Damon) had been introduced to organized crime by Irish-American mobster Frank Costello (Nicholson) in the Irish neighborhood of South Boston. Over the years, Costello grooms him to become a mole inside the Massachusetts State Police, until Sullivan is accepted into the Special Investigations Unit, which focuses on organized crime.
Lorna Cole (Rene Russo) is pregnant with LAPD sergeant Martin Riggs' baby; they are not married, but both are thinking about it. Police sergeant Roger Murtaugh's daughter Rianne (Tracie Wolfe), is also pregnant, and Riggs later learns from Lorna that Rianne has secretly married Lee Butters (Chris Rock), a young detective who works at the same station as Murtaugh and Riggs – secretly because Roger had made it clear that he does not want his daughter to marry a police officer. Due to the many disasters caused by both sergeants while on duty, the police department has lost its insurance carrier, and cannot get a new one while they're still out on the streets. Because firing them is not an option, the Chief uses a special privilege and they get temporarily promoted to captains, given that there aren't any lieutenant spots available.
Eight years after the events of the first film, Miami Police Department (MPD) narcotics division detectives Marcus Burnett and Mike Lowrey are investigating the flow of highly-potent ecstasy into the city. Their surveillance of boats coming in from Cuba leads them to a Ku Klux Klan meeting and drug drop in a swamp docks outside Miami. The subsequent raid on the Klan members proves to be a disaster; malfunctioning radios delay back-up, causing a firefight when Mike accidentally shoots Marcus in the buttocks, while the Klan members are revealed to be mere small-time buyers and not the distributors of the ecstasy. The incident leaves Marcus to further question if he still wants to partner with Mike, while Mike fears that Marcus may discover his new relationship with Marcus' sister, Syd.
Mitch McDeere (Tom Cruise) is a young man from an impoverished background, but with a promising future in law. About to graduate from Harvard Law School near the top of his class, he receives a generous job offer from Bendini, Lambert & Locke, a small, boutique firm in Memphis specializing in accounting and tax law. He and his wife, Abby (Jeanne Tripplehorn), move to Memphis and Mitch sets to work studying to pass the Tennessee bar exam. Avery Tolar (Gene Hackman), one of the firm's senior partners, becomes his mentor and begins introducing Mitch to BL&Ls professional culture, which demands complete loyalty, strict confidentiality, and a willingness to charge exceptional fees for their services. Seduced by the money and perks showered on him, including a house and car, he is at first totally oblivious to the more sinister side of his new employer, although Abby has her suspicions. Mitch passes the bar exam and begins working long hours that put a strain on his marriage. Working closely with Avery, Mitch learns that most of the Firm's work involves helping wealthy clients hide large amounts of money in off-shore shell corporations and other dubious tax-avoidance schemes. While on a trip to the Cayman Islands on behalf of a client, Mitch lets himself be seduced by a local woman. But the encounter is a set-up and their tryst on the beach is photographed by people working for the firm's sinister "head of security", Bill DeVasher (Wilford Brimley), who uses it to blackmail Mitch into keeping quiet about what he knows.
Walt Kowalski (Clint Eastwood) is a cantankerous, retired Polish American assembly line worker and Korean War veteran, who has recently been widowed after 50 years of marriage, causing him to be a lapsed Catholic. His Highland Park, Michigan neighborhood in the Detroit area, formerly populated by working class white families, is now dominated by poor Asian immigrants, and gang violence is commonplace. Adding to the isolation he feels is the emotional detachment of his family.
In 1968, Frank Lucas, the limo driver-turned-right-hand man of Harlem gangster Ellsworth "Bumpy" Johnson, inherits Johnson's gang when Johnson dies of a heart attack. Disliking the new, flashy gangsters of the neighborhood, Lucas decides to take control of Harlem's crime scene.
L.A.P.D. Detective Carter is directing traffic. Concurrently, Chinese Ambassador Han addresses the importance of fighting the Triads at the World Criminal Court, announcing that he may know the whereabouts of Shy Shen, a semi-mythical individual of great importance to the Chinese mob. Before announcing, an assassin shoots Han in the shoulder, disrupting the conference. Chief Inspector Lee pursues the shooter and corners him, discovering that the assassin is his childhood Japanese friend Kenji. When Lee hesitates to shoot Kenji, he makes his escape when Carter (having heard what's happening over the police radio) arrives and tries to intervene.