Des gamins des rues, avec à leur tête Joe Kirby, tentent de mettre fin aux agissements d'un escroc qui réussit à pirater les bandes dessinées d'un journal pour transmettre des messages codés à une bande de gangsters. Une bagarre mémorable, à laquelle tous les gosses du quartier prennent part, permettra d'arrêter le faussaire et ses acolytes.
A popular performer, Jeannie Laird decides to buy her first house and celebrate with a big party. The guests' enjoyment is interfered with by the happenings at the home of the next door neighbor, Bill Carter.
American Splendor retrace la véritable histoire du scénariste de comics Harvey Pekar. Au début du film, celui-ci mène une existence plutôt morose entre son travail de documentaliste, quelques conversations sur tout et rien avec ses collègues et quelques connaissances, et sa passion pour le jazz, qu'il assouvit en recherchant des pièces rares dans les garage sales (équivalent américain des vide-greniers) ou les magasins d'occasion. C'est ainsi qu'il fait la connaissance du célèbre dessinateur de bande dessinée Robert Crumb, alors inconnu, qui est lui aussi collectionneur. Plusieurs années plus tard, alors que Crumb est devenu célèbre, Harvey lui soumet les story-boards d'un projet de bande dessinée basée sur sa vie, lui proposant d'en assurer le dessin. Crumb accepte, et contre toute attente, cette série intitulée American Splendor relatant une vie simple, banale, obtient un grand succès. Harvey Pekar acquiert ainsi une certaine célébrité aux États-Unis, dont les conséquences sur sa vie quotidienne sont présentées dans le film. En particulier, American Splendor lui permet de rencontrer sa future femme Joyce Brabner, qui écrit elle aussi des comics, et avec qui il va réaliser d'autres histoires autobiographiques, également intégrées en partie dans le film (notamment Our Cancer Year).
Rick Todd (Dean Martin) is a struggling painter and smooth-talking ladies' man. His goofy young roommate Eugene Fullstack (Jerry Lewis) is an aspiring children's author who has a passion for comic books, especially those of the mysterious and sexy "Bat Lady."
Riggan Thomson (Michael Keaton) is a faded Hollywood actor best known for playing the superhero Birdman decades ago in a series of films. He is often tormented by the mocking, critical inner voice of Birdman, and frequently visualizes himself performing feats of levitation and telekinesis. The film opens with a quotation from Raymond Carver stating that the main fulfillment in life is related to having once been loved, then cuts to a dramatic atmospheric disturbance resembling a meteor descending in flames. The film then cuts to a surreal shot depicting Riggan as levitating in his stage room. Riggan hopes to reinvent his career by writing, directing, and starring in a Broadway production of a loosely based adaptation of Carver's short story "What We Talk About When We Talk About Love".
Stanley Ford (Jack Lemmon) is a successful, happily unmarried cartoonist enjoying the comforts of a well-to-do existence in an urban townhouse, including the services of his loyal and attentive valet, Charles Firbank (Terry-Thomas). Stanley's comic strip, Bash Brannigan, is a secret-agent thriller characterized by a high level of realism: no matter how outrageous the plot may seem, Stanley will not allow Brannigan to do anything physically impossible or use gadgets that don't exist. He hires actors and sets up elaborate enactments of storylines, playing Brannigan himself, while Charles takes photographs Stanley will use as models.
Woodrow "Woody" Wilkins is an imaginative, yet eccentric, comic book writer and illustrator who demands a sense of realism for his comic book hero "Condorman", to the point where he crafts a Condorman flying suit of his own and launches himself off the Eiffel Tower. The test flight fails as his right wing breaks, sending him crashing into the Seine River. Later after the incident, Woody is asked by his friend, CIA file clerk Harry, to perform what appears to be a civilian paper swap in Istanbul. Upon arriving in Istanbul, he meets a beautiful Soviet named Natalia Rambova, who poses as the Soviet civilian with whom the exchange is supposed to take place, but it is later revealed that she is in fact a KGB spy. Woody does not tell Natalia his real name, and instead fabricates his identity to her as a top American agent code-named "Condorman". During the encounter, Woody fends off a group of would-be assassins and saves her life by sheer luck before accomplishing the paper trade. Impressed by Woody, and disgusted by how she was treated by her lover/boss Krokov when she returns to Moscow, Natalia decides to defect and asks the CIA to have "Condorman" be the agent that helps her.
In 1945 Las Vegas, World War II veteran Frank Harris (Brad Pitt) returns to his mother. Riding on a motorcycle that he won in Italy during his service, Frank and his mother are struck by a drunk couple. Frank survives, but his mother dies. As an ambulance truck takes her away, Frank is transported to "Cool World", an animated city of surrealistic landscapes and random cartoon violence. He was inadvertently teleported by Dr. Vincent Whiskers (Maurice LaMarche), a doctor who created a "spike" that was supposed to take him to the real world, but brought Frank to Cool World instead. Whiskers finds Frank useful enough to run things in the Cool World while he is gone to the real world.
In Paris in 1969, young film editor Paul Ballard (Jeremy Davies) is currently working on a science-fiction adventure film called Codename: Dragonfly, written and directed by renowned director Andrezej (Gérard Depardieu).
Crumb is about the experiences and characters of the Crumb family, particularly Robert Crumb's brothers, Maxon and Charles, his wife and children (his sisters declined to be interviewed). Though Zwigoff had the consent of the Crumb brothers, some questioned the ability of the more disturbed brothers to provide that consent.
John Callahan , devenu tétraplégique à l'âge de vingt-et-un ans à cause de son alcoolisme, trouve dans le dessin une forme de thérapie avant de devenir un célèbre dessinateur de bandes dessinées.
Joey Wellman, an American cartoonist from Cleveland now largely forgotten at home, visits France with his partner Lena to attend an exhibition in Paris about the comic strip (bande dessinée) which features his work. He also hopes to be reconciled with his daughter Elsie who has been a student in Paris for two years, in flight from the American culture of which she sees her father as a typical example. Elsie is naively infatuated with French literature, and is trying to secure an introduction to the brilliant university professor Christian Gauthier, an expert on Flaubert but also an enthusiast for comic books. The meeting of father and daughter goes badly, but Elsie is persuaded to join Joey and Lena for the weekend at the country house of Gauthier's mother, Isabelle. During a comic-themed masquerade party, all of the characters are made to reconsider their present and past relationships.
Bob Neuman, jeune Suisse mythomane, invite chez lui un auteur de bandes dessinées dont il admire l'œuvre, Pierre Meyrand, et son épouse Jacqueline. L'artiste profite de cette rencontre pour imaginer un nouveau personnage totalement inspiré de son hôte, mais ce dernier suit le scénario de la bande dessinée de son invité dans sa propre vie.
American caricaturist Jim Crocker is a popular womanizer in London known by his pen name 'Piccadilly Jim'. He supports his father James, an out-of-work actor with a great admiration for Shakespeare, but also with an inability to remember lines from the Bard's work. Most characters in the film describe James as a ham. Jim lives with his impeccable valet, Bayliss. Jim is happy when he finds out that his father is to be engaged to Eugenia Willis, until it turns out that Eugenia's overbearing sister, Nesta Pett, refuses to give permission for the marriage due to doubts of James' sincerity and his financial background. One morning, James' tries to introduce the Petts to his son, whom he describes as an artist, but Jim, who has stayed out all night drinking again, comes staggering in to find that Nesta Pett has discovered that the "artist" is a caricaturist, which does not impress her.