Don Anderson is the Mickey's hamburger chain marketing director who helped develop the "Big One", its most popular menu item. When he learns that independent research has discovered a considerable presence of fecal matter in the meat, he travels to the fictitious town of Cody, Colorado to determine if the local Uni-Globe meatpacking processing plant, Mickey's main meat supplier, is guilty of sloppy production. Don's tour shows him only the pristine work areas and most efficient procedures, assuring him that everything the company produces is immaculate.
Bernard is a teacher in the suburbs and lives with Victoria. Didier is a wealthy Parisian pharmacist and is married to Murielle, Victoria's sister. While the former drives a rusty car, the latter drives a black Mercedes. Both brothers-in-law are complete opposites and hate each other. During dinner, Didier and Bernard make a bet: to stop smoking for fifteen days, until the next family get-together. The first days go off like a dream and both are on top of the world. But things quickly turn sour. Didier and Bernard find it harder and harder to resist the temptation. They become irritable, suspicious, they lie; until the fifteenth day: the family get-together. They have kept their word, but relations between them and their wives are at an all time low. Despite this, they are both determined to remain non-smokers.
Trajectoires croisées d'une jeune femme en lutte contre le quotidien, de sa mère en déni de surpoids, de son copain en pertes de repères et d'un vieillard esseulé. Jusqu'au drame...
À Ramlé, en Israël, quatre amis obèses décident d'arrêter les régimes, et adoptent la culture sumo. L'un d'eux, Herzl, va même jusqu'à tenter de se faire entraîner par Kitano, un ancien entraîneur japonais exilé en Israël à la suite de ses déboires avec les yakusas.
Dans un couple en perdition, l'épouse tente de rendre son mari jaloux en faisant semblant de le tromper avec un obèse, Canabol. Celui-ci tente alors de maigrir.
Richard Séléna, commissaire principal de 160 kg du SRPJ de Marseille, comprend que la très belle Elsa, artiste peintre, aurait tué son oncle, Victor Lachaume, armateur du port. Il pense en avoir les preuves. Si elle n'avoue pas vraiment, elle ne semble pas contester la conviction du policier.
En plein lycée, Jochem est fréquemment malmené par ses trois camarades à cause de son obésité sous les yeux des autres lycéens qui n'osent le soutenir… et David, ayant le cœur brisé, tente de le secourir.
Jim is a 12-year-old outsider. He has a mother with anxiety and he lives a hard life. At school he is smallest in his class, and compelled to buy beer and smoke and have party's in his garage. Home is different: He's the father of the house, and takes care of his mother, who has isolated herself in bed with a video of the moon landing on VHS. She's not going out of her house due to anxiety. One day Terje (an overweight boy who claims to own a pit bull) starts in his class. He gets excluded from the class society, but he considers Jim as his best friend making him choose between an outsider friend and his poor social status.