Le Titan Thanos ayant réussi à s'approprier les six Pierres d'Infinité et à les réunir sur le Gantelet doré, a pu réaliser son objectif de pulvériser la moitié de la population de l'Univers d'un claquement de doigts. Les quelques Avengers et Gardiens de la Galaxie ayant survécu, Captain America, Thor, Natasha Romanoff, Bruce Banner, War Machine, Nébula et Rocket, espèrent réparer le méfait de Thanos. Ils le retrouvent mais il s'avère que ce dernier a détruit les pierres et Thor le décapite. Cinq ans plus tard, alors que chacun essaie de continuer sa vie et d'oublier les nombreuses pertes dramatiques, Scott Lang, alias Ant-Man, parvient à s'échapper de la dimension subatomique où il était coincé depuis la disparition du Docteur Hank Pym, de sa femme Janet Van Dyne et de sa fille Hope Van Dyne. Lang propose aux Avengers une solution pour faire revenir à la vie tous les êtres disparus, dont leurs alliés et coéquipiers : récupérer les Pierres d'Infinité dans le passé grâce à l'univers quantique.
Harry Potter, now aged 13, has been spending another dissatisfying summer at Privet Drive. When Uncle Vernon's sister, Marge, insults Harry's parents, he becomes angry and accidentally causes her to inflate and float away. Harry flees with his luggage, fed up with his life with the Dursleys. The Knight Bus delivers Harry to the Leaky Cauldron, where he is forgiven by Minister of Magic Cornelius Fudge for using magic outside of Hogwarts. After reuniting with his best friends Ron and Hermione, Harry learns that Sirius Black, a convicted supporter of the dark wizard Voldemort, who murdered Harry's parents, has escaped Azkaban prison, intending to kill Harry.
Shrek has grown steadily tired of being a family man and celebrity among the local villagers, leading him to yearn for the days when he felt like a "real ogre". When he takes his family to Far Far Away to celebrate his children's first birthday, a series of mishaps further injure his ego, causing him to lose his temper and walk out in anger.
In the future, robots known as Sentinels are exterminating mutants and their human allies. A band of mutants, including Kitty Pryde, Colossus, Iceman, Bishop, Warpath, Blink and Sunspot, evade the Sentinels due to Pryde's ability to send a person's consciousness to the past. Pryde's group convenes with Logan, Storm, Professor Charles Xavier, and Erik Lehnsherr at a monastery in China. Pryde sends Logan's consciousness 50 years back in time to 1973 to prevent Mystique from assassinating Dr. Bolivar Trask, creator of the Sentinels. Following the assassination, Mystique was captured, and her DNA was used by Trask's company to improve the Sentinels, whose ability to adapt to any mutant power makes them almost invincible. Xavier and Lehnsherr advise Logan to find both of their younger selves for help.
A young monster named Michael "Mike" Wazowski dreams of being a scarer (a monster who enters the human world at night to scare children so their screams can be harvested for energy) when he grows up, after visiting Monsters Inc. (Monstropolis' most profitable and best-known scaring company) on a school field trip. Eleven years later, Mike is a first-year scare major at Monsters University, where he meets a monster named James P. "Sulley" Sullivan.
Crop blight has made growing food on Earth nearly impossible, threatening the existence of humanity. Joe Cooper, a widowed former NASA pilot, runs a farm with his father-in-law Donald, son Tom, and daughter Murphy. Murphy believes her bedroom is haunted by a poltergeist. When the "ghost" creates a pattern of dust on the floor, Cooper realizes an unknown intelligence is using gravity to communicate, and interprets the pattern as geographic coordinates, which Cooper and Murphy follow to a secret NASA installation.
In 2012, an alien criminal, Boris the Animal, a Boglodite, escapes from a maximum-security prison on the moon and arrives on Earth, bent on taking revenge on Agent K, who shot off his left arm and captured him in 1969. He confronts K, who is with his partner Agent J, telling him he is "already dead". J then discovers that K was responsible not only for capturing Boris, but for deploying the "ArcNet", a shield that prevented the Boglodites from conquering Earth and caused their extinction.
As the Smurfs get ready for the Blue Moon Festival, Papa Smurf sees in his cauldron a vision of Clumsy Smurf reaching for a dragon wand and the Smurfs in cages while Gargamel laughs. Not wanting this vision to come true, Papa Smurf disallows Clumsy to pick Smurf Roots. Clumsy disobeys Papa and ends up unintentionally leading Gargamel and Azrael to the village. The Smurfs all flee for their lives while Clumsy unknowingly runs towards the Forbidden Falls, with Papa Smurf, Smurfette, Grouchy, Brainy and Gutsy running after him. They find him at the edge of a cliff, and while trying to help him up, they are sucked into a gigantic vortex that spirits them to present day New York City. To make matters worse, Gargamel and Azrael follow and the Smurfs end up in the apartment of Patrick and Grace Winslow, a married and expectant couple and their Basset Hound Elway. After clarifying things, the Winslows befriend them and allow them to stay in their apartment. The next day, needing to find a "star gazer" (a telescope), the Smurfs follow Patrick to his work place at Anjelou Cosmetics, misunderstanding the previous explanation of his job as fortune-telling. He calls Grace to pick them up.
The parallel city of Monstropolis is inhabited by monsters and powered by the screams of children in the human world. At the factory of Monsters, Inc., employees called "scarers" venture into children's bedrooms to scare them and collect their screams, using closet doors as portals. This is considered a dangerous task because the monsters believe children are toxic and that touching them would be fatal. However, production is falling as children are becoming harder to scare and the company's chairman Henry J. Waternoose III is determined to find a solution. The top scarer is James P. "Sulley" Sullivan, who lives with his friend and assistant Mike Wazowski and has a rivalry with the ever-determined chameleon-like monster Randall Boggs. During an ordinary day's work on what is known as the "Scarefloor", another scarer accidentally brings a child's sock into the factory, causing the Child Detection Agency (CDA) to arrive and cleanse him. Mike is frequently ridiculed by the company's clerk Roz for never completing his paperwork on time.
Suneo shows everyone a fossilized claw of a Tyrannosaurus rex and Nobita is angry that he doesn't get a look. Nobita claims that he will be able to find a living dinosaur. Panicking, Nobita researches on dinosaurs and starts digging in a hill. But then, a landlord shouts at him and makes him dig a hole in the ground to dispose of some egg shells. Nobita unearths a rock shaped like an egg. Using the time-wrap, he returns the rock into its former form and plans to hatch the egg. He spends a day and night wrapped tightly in a blanket with it on his futon, despite it being the peak of summer. A "Futabasaurus" comes out, and Nobita decides to name the plesiosaur Piisuke. Suneo and Gian come looking for Nobita but because Piisuke is still too small, Nobita doesn't show them the plesiosaur and instead makes a deal with them. If he cannot show them a real dinosaur, he would have to eat spaghetti through his nose. Meanwhile, Nobita and Piisuke form a strong bond between them with Nobita working very hard to make sure the baby plesiosaur is well looked after, feeding it his own dinner of sashimi and playing with it. He grows very attached to Piisuke.
In 1995, John Connor is ten years old and living in Los Angeles with foster parents. His mother Sarah Connor had been preparing him throughout his childhood for his future role as the leader of the Human Resistance against Skynet, but was arrested after attempting to bomb a computer factory and imprisoned at a mental hospital under the supervision of Dr. Silberman. Skynet sends a new Terminator, designated as T-1000, back in time to kill John. The T-1000 is an advanced prototype composed of a mimetic polyalloy that allows it to take on the shape and appearance of almost anything it touches, and transform parts of its anatomy into knives and other stabbing weapons. The T-1000 arrives under a freeway, kills a policeman and assumes his identity. Meanwhile, the future John Connor has sent back a reprogrammed T-800 (Model 101) Terminator to protect his younger self.
In 2029, Human Resistance leader John Connor (Jason Clarke) launches a massive final offensive against Skynet, an artificial general intelligence system seeking to eliminate the human race. Before the Resistance wins the offensive, Skynet activates a time machine and sends back a T-800 Terminator to 1984 to kill John's mother, Sarah Connor (Emilia Clarke). John's right-hand man, Kyle Reese (Jai Courtney), volunteers to travel back in time to protect her. As Kyle floats in the machine's magnetic field, he witnesses John being attacked by another Resistance soldier (Matt Smith). He then has visions from his childhood about events in 2017.
John Connor has been living off the grid in Los Angeles in the years following the death of his mother, Sarah, from leukemia. Although Judgment Day did not occur on August 29, 1997, as expected, John still believes that a war between humans and the machines will occur. Unable to locate John in the past, Skynet sends a new model of the Terminator called the T-X back to July 24, 2004 to kill other members of the Human Resistance. The T-X is more advanced than previous Terminators, and has an endoskeleton with built-in weaponry, a liquid metal exterior similar to the T-1000, and the ability to reprogram other machines. Unlike previous Terminators, its standard appearance is female. The Resistance sends a reprogrammed Terminator (T-850 - Model 101) back in time to protect the T-X's targets including John and his future wife, Kate Brewster.
In the 23rd century, the Federation starship USS Kelvin is investigating a "lightning storm" in space. A Romulan ship, the Narada, emerges from the storm and attacks the Kelvin. Narada 's first officer, Ayel, demands that the Kelvin 's Captain Robau come aboard to negotiate a truce. Once aboard, Robau is questioned about the current stardate and an "Ambassador Spock", whom he professes not to know. Narada 's commander, Nero, kills him, and continues his attack on the Kelvin. George Kirk, the Kelvin 's first officer, orders the ship's personnel, including his pregnant wife Winona, to evacuate the ship while he pilots the Kelvin on a collision course with the Narada, as the auto-pilot function has been damaged. At the cost of his life, Kirk ensures Winona's survival as she gives birth to James T.
Teenager Marty McFly is an aspiring musician dating girlfriend Jennifer Parker in Hill Valley, California. His father George is bullied by his supervisor, Biff Tannen, while his mother Lorraine is an overweight, depressed alcoholic. Whilst expressing disapproval of Marty's relationship with Jennifer, Lorraine recounts how she met George when her father hit him with a car.