Bella awakens from her transformation from human to vampire, aware of her new abilities, but unaware of changes within the coven, such as Jacob having imprinted on her child, Renesmee. It also appears that Bella's father, Charlie, has been attempting to contact the Cullens for updates on Bella's illness. They intend to tell him she didn't survive, which requires that they move out of Forks, Washington to protect their identities. Jacob, desperate not to lose Renesmee, tells Charlie that his daughter is in fact alive and well, and explains that Bella has had to change in order to survive. He morphs into a wolf, revealing his tribe's shape-shifting power, but does not tell Charlie about vampires.
Bella Swan is getting ready for her wedding. During the reception, her best friend, Jacob Black the were-wolf returns after hearing about Bella and Edward's engagement. While dancing with him in the woods, away from everyone else, Bella admits that she and Edward plan to consummate their marriage on their honeymoon while she's still human. Jacob becomes furious, knowing that Edward could easily kill Bella but the other wolves restrain him from hurting Edward.
On her 18th birthday, Bella Swan wakes up from a dream in which she sees herself as an old woman. She expresses her distaste about growing older than her boyfriend Edward Cullen, a vampire who stopped aging physically at 17. Despite her lack of enthusiasm, Edward's adoptive family throw Bella a birthday party. While unwrapping a gift, Bella gets a paper cut. Edward's brother, Jasper, becomes overwhelmed by the scent of Bella's blood and attempts to kill her. Realizing the danger that he and his family pose to Bella, Edward ends their relationship, and the Cullens leave Forks, Washington.
In Seattle, not far from Forks, Victoria (Bryce Dallas Howard) attacks and bites Riley Biers (Xavier Samuel), in order to begin creating an army of newborns with him. Back in Forks, Edward Cullen (Robert Pattinson) and Bella Swan (Kristen Stewart) discuss the complications of becoming an immortal vampire. At 18 years old, one year older than the age Edward was when he became a vampire, Bella expresses her aversion to the idea of marrying so young, though Edward refuses to turn her into a vampire until they are married, his argument that she should have various human experiences she would otherwise miss. While Charlie Swan (Billy Burke) investigates the disappearance of Riley Biers, Edward suspects his disappearance was caused by the newborn vampires, furthering his suspicions is Riley's intrusion into Bella's room.
In 2009, a genetically re-engineered measles virus, originally created as a cure for cancer, turns into a lethal strain which kills 90% of those it infects, and mutates the remaining 10% into predatory, nocturnal mutants called "Darkseekers" who are extremely vulnerable to sunlight and other sources of UV. Three years after the outbreak, US Army virologist Lieutenant Colonel Robert Neville (Will Smith) lives an isolated life in the ruins of New York City, which is now deserted, unsure if any other uninfected humans are left in the world.
A short time after the first film, Mavis (Selena Gomez) and her fiance Johnny (Andy Samberg) are married, with the approval of her father Dracula (Adam Sandler) and the world has become aware of (and unfased by) the existence of monsters. Mavis later reveals to Drac that she is pregnant and a year later, she gives birth to a son named Dennis (Asher Blinkoff), who befriends Wayne's werewolf pup daughter Winnie (Sadie Sandler). Nearing his fifth birthday, Dennis has yet to grow his fangs and Drac worries that his grandson might not gain vampire powers. Noticing the dangers of Transylvania, Mavis starts to consider raising Dennis where Johnny grew up, much to Drac's disapproval.
Seventeen-year-old Isabella "Bella" Swan moves to Forks, a small town on the Washington coast, to live with her father, Charlie. Her mother, Renée, is remarried to a minor league baseball player, and they are often traveling. Bella makes many friends at her new high school, but she is intrigued by the mysterious and aloof Cullen siblings. Bella sits next to Edward Cullen in biology class on her first day of school, but he seems to be repulsed by her. A few days later, Bella is nearly struck by a van in the school parking lot. Edward saves her by instantaneously covering a distance of some 30 feet and putting himself between Bella and the van, stopping it without injury with only his hand. He subsequently refuses to explain his actions to Bella and warns her against befriending him.
In the aftermath of the death of Dracula's wife Martha (Jackie Sandler) at the hands of an angry mob, Count Dracula (Adam Sandler) designs and builds a massive five-star hotel in Transylvania in which to raise his daughter Mavis (Selena Gomez) and to serve as a getaway for all the world's monsters.
In 1887, Transylvanian Doctor Victor Frankenstein brings to life his Monster with the aid of his assistant Igor and Count Dracula. After Dracula betrays and kills Doctor Frankenstein, the Monster escapes to a windmill, which is burned down by a pursuing mob. The mob flees as Dracula and his three brides mourn the loss of the Monster.
In the Middle Ages, Vlad Tepes (Luke Evans) is the Prince of Wallachia and Transylvania. As a child, he was a princely hostage of the Ottoman Empire and was trained to be a soldier in the Sultan's elite Janissary corps, where he became their most feared warrior. He was called Vlad the Impaler after slaughtering thousands by impaling them on spears. Eventually sickened by his acts, he put aside his past and returned to rule his domains in peace. One day in the forest, Vlad and his soldiers discover a helmet in a stream. Fearing that an Ottoman scouting party is preparing the way for invasion, they follow the stream to a high mountain cave called Broken Tooth Mountain. Upon entering the cave, they discover the ground of the cave is carpeted in crushed bone; and they are attacked in the dark by an unknown creature (Charles Dance) with shining red eyes, as well as inhuman speed and strength. While his men are killed, Vlad cuts the creature of the cave with his sword before being thrown to the ground. The blood on the sword he used to cut the creature dissolves when exposed to sunlight, and the creature does not pursue Vlad into the sunlight at the mouth of the cave. Returning to his castle, Vlad learns from a local monk that the creature is a vampire, who was once a man who summoned a demon from the depths of hell and made a pact with it for dark powers before being tricked by the demon and cursed to remain in the cave forever until he is released by someone who drinks his blood, then drinks the blood of a human. The person is welcome to share his power in exchange for the freedom to escape the cave.
In 1462, Vlad Dracula, a member of the Order of the Dragon, returns from a victory against the Turks to find his wife, Elisabeta, has committed suicide after receiving a false report of his death. Enraged that his wife is now damned for committing suicide, Dracula desecrates his chapel and renounces God, declaring that he will rise from the grave to avenge Elisabeta with all the powers of darkness. In a fit of rage, he stabs the chapel's stone cross with his sword and drinks the blood which pours out of it.
In 1899, men dressed as German soldiers, using a large armored vehicle and wielding machine guns, attacked the Bank of England and stole Leonardo da Vinci’s layouts of Venice’s foundations. Shortly after, led by their leader the “Fantom”, men dressed as British officers, again using highly advanced technology for the time, kidnapped German scientists and destroyed a factory, causing tension between the United Kingdom and Germany, which could lead to an international war. Sanderson Reed (Tom Goodman-Hill) of the British Empire ventures to Kenya, visiting a Gentleman's club to recruit world-renowned hunter and adventurer Allan Quatermain (Sean Connery). Quatermain, retired and mourning the loss of his son after his last adventure, has no interest in serving the British Empire further. After armed men attempt to assassinate Quatermain, he is left with no-other choice but to agree to go with Reed to London and meet with Reed's superior officer to help keep the threat of a war from spilling into Africa.
Six months after the events of the second film, humans have captured Selene during "The Purge", a global military crusade to exterminate vampires and lycans. Vampires have waged guerrilla warfare against the government, but the humans have overrun them, forcing the survivors to hide underground and resist the humans on their own.