Two American college students, David Kessler (David Naughton) and Jack Goodman (Griffin Dunne), backpack across the North York Moors. As darkness falls, they stop for the night at a pub called "The Slaughtered Lamb". Jack notices a five-pointed star on the wall. When he asks about it, the pubgoers stop talking and become hostile, telling them to keep to the road and beware of the full moon. The pair decide to leave, but while talking they wander off the road onto the moors.
Darren Shan and his best friend Steve Leonard visit a traveling freak show. Steve believes a performer, Larten Crepsley, is a vampire. Steve talks to Crepsley after the show and asks to become a vampire. Crepsley initially refuses but is talked into testing Steve's blood, that he spits out telling Steve he has bad blood. Steve furiously swears revenge and leaves. Darren overhears everything because he has been hiding in a cupboard after stealing Crepsley's spider, Madam Octa.
Andy McDermott is a tourist seeing the sights of Paris with his friends Brad and Chris. When Serafine Pigot leaps off the Eiffel Tower just before Andy is about to bungee jump, he executes a mid-air rescue. She vanishes into the night, leaving Andy intrigued – and also unaware that she is the daughter of David Kessler and Alex Price, the couple seen 16 years earlier in the first film. That night, Andy, Chris, and Brad attend a night club called "Club de la Lune". The club's owner, Claude, is actually the leader of a werewolf society that uses the club as a way to lure people (preferring tourists) in to be killed. Serafine arrives, tells Andy to run away and transforms into a werewolf. The club owners transform into werewolves as well and butcher all the guests. Chris escapes and goes back to Serafine's house. Brad's heart is eaten by a werewolf and Andy is bitten by another werewolf.
The film is set in Bailey Downs, a suburb where a rash of dog killings has been occurring. Brigitte and Ginger Fitzgerald are teenage sisters who harbor a fascination with death and, as children, formed a pact to die together. One night, while on the way to kidnap a dog owned by school bully Trina Sinclair, Ginger begins her first period, which results in the girls being attacked by the creature responsible for the maulings. The creature wounds and bites Ginger, but Brigitte rescues her. As the girls flee, the creature is run over by a van belonging to Sam MacDonald, a local drug dealer. Ginger decides not to go the hospital as her wounds heal quickly.
The film begins in Hollywood Los Angeles, when two friends, Jenny Tate and Becky Morton, are at a pier and decide to get their fortune told by Zela, asking about a boy. Zela foretells that they will suffer a horrible fate, but they don't believe her and walk away laughing. A little while later, Becky realizes Jenny has disappeared and can't find her on the pier.
In medieval Europe, Philippe Gaston (Broderick), a thief facing execution who is known as "The Mouse", escapes from the dungeons of Aquila via the sewers. The Bishop of Aquila (Wood) sends his Captain of the Guard, Marquet (Hutchison), to hunt Philippe down. At a country tavern, Philippe unknowingly reveals himself to Marquet and his men, and is about to be killed. But the former captain, Etienne of Navarre (Hauer), intervenes and defeats Marquet and his men. He then takes Philippe away.
Karen White (Dee Wallace) is a Los Angeles television news anchor who is being stalked by a serial murderer named Eddie Quist (Robert Picardo). In cooperation with the police, she takes part in a scheme to capture Eddie by agreeing to meet him in a sleazy porno theater. Eddie forces Karen to watch a video of a young woman being raped, and when Karen turns around to see Eddie she screams. The police enter and shoot Eddie, and although Karen is safe, she suffers amnesia. Her therapist, Dr. George Waggner (Patrick Macnee), decides to send her and her husband, Bill Neill (Christopher Stone), to the "Colony", a secluded resort in the countryside where he sends patients for treatment.
Jane Coslaw (Follows), the narrator of the film, is the oldest sister in a dysfunctional family of four. Her narration starts in the Spring of 1976 and centers on her strained relationship with her younger, paraplegic brother Marty (Haim) and their parents Nan and Bob. Their rocky relationship changes after a series of murders in their small rural town of Tarker's Mills, Maine.
Former NYPD Captain Dewey Wilson (Albert Finney) is brought back to the force and assigned to solve a bizarre string of violent murders after high-profile magnate Christopher Van der Veer (Max M. Brown), his wife (Anne Marie Pohtamo), and his bodyguard are slain in Battery Park. Executive Security, Van der Veer's client, prefers to blame the murders on terrorists; but knowing that the victim's bodyguard was a 300-pound Haitian with voodoo ties makes Wilson skeptical. At the crime scene, Wilson meets with Warren (Dick O'Neill), his superior. With pressure to solve the case coming down from both the Police Commissioner and the Mayor, Warren partners Wilson with criminal psychologist Rebecca Neff (Diane Venora). Meanwhile, a homeless man goes exploring an abandoned church in Charlotte Street, South Bronx, which was going to be demolished by Van der Veer along with the rest of the ruined buildings in the area, to be able to build apartment complexes. He is suddenly attacked and torn to pieces by an unseen monstrous being. Wilson and Neff arrive to investigate his murder. While investigating the abandoned church, sounds of crying lure Neff up the bell tower. Wilson follows her but doesn't hear the crying; however, once Neff is separated from him, he hears a wolf howl. He goes up after Neff and drags her forcibly to safety. Later, during the night, a bridge worker is apparently murdered by the same creature.
Todd Howard (Jason Bateman), the cousin of Scott Howard, has recently been accepted into Hamilton University on a full athletic scholarship on the recommendation of Coach Bobby Finstock (Paul Sand), who was Scott's basketball coach at Beacontown High. Finstock's hope is that Todd has the family genes to become a werewolf and turn Finstock's new struggling boxing team into championship contenders. Having never been much good at sports, and because he is more interested in being a veterinarian, Todd is certain that Finstock has the wrong guy. During a meet and greet reception of school alumni, Todd has his first "wolf-out" while dancing with a seductive hostess. At first, Todd is horrified by his "family affliction", and fellow students begin to harass him. Then, during his first boxing match, after nearly getting knocked out, Todd has his second "wolf-out" only this time he is able to display his supernatural agility and strength and has a dramatic come from behind victory, thus earning the admiration of the students as well as the strict Dean Dunn (John Astin).
Jack Harrison (Goldblum) and Gil Turner (Begley) are writers for The Sensation, a supermarket-grade tabloid run by Turner's father, Mac (Norman Fell). Jack is a more serious journalist using The Sensation as a stepping stone to a better career, while Gil is a gangling yes-man ever ready to win his father's approval.
Vivian (Agnes Bruckner) is a nineteen-year-old werewolf born in Bucharest, Romania to American parents who then moved back to America. When Vivian was nine years old, her parents and two siblings were killed by two hunters who then proceeded to burn down their house. She then moved back to Bucharest to live with her aunt Astrid (Katja Riemann), who was the mate of the pack's leader, Gabriel (Olivier Martinez) at that time. To Astrid's distress, Gabriel left her after seven years in accordance with pack law to choose a new mate. The culmination of another seven years is only a few months away and Gabriel wants the reluctant Vivian as his.
Four vampires - Viago, Vladislav, Deacon, and Petyr - share a flat in the Wellington suburb of Te Aro. Although Viago, Vladislav, and Deacon are all several centuries old, they have retained normal human appearances, but the 8,000-year-old Petyr resembles Count Orlok and acts more savagely than the younger vampires. Each night, Viago, Vladislav, and Deacon prowl the streets of Wellington searching for people to kill, but they must stay in the flat during the day to avoid sunlight—which is lethal to vampires—therefore they have not adapted to 21st-century life. Deacon has a human servant (familiar)—Jackie—who runs errands for the vampires, but she is frustrated that Deacon will not turn her into a vampire. Jackie leads her ex-boyfriend Nick to the vampire's flat so they can drink his blood: he escapes before they can kill him, but as he leaves the flat, Petyr attacks him and later turns Nick into a vampire.
Lawrence Talbot (Lon Chaney, Jr.) is making an urgent call from London to a Florida railway station where Chick Young (Bud Abbott) and Wilbur Grey (Lou Costello) work as baggage clerks. Wilbur answers the phone and Talbot tries to impart to him the danger of a shipment due to arrive for the "McDougal House Of Horrors" (a local wax museum) which purportedly contains the actual bodies of Count Dracula (Béla Lugosi) and the Frankenstein Monster (Glenn Strange). However, before he is able to warn Wilbur, a full moon rises and Talbot transforms into a werewolf, who proceeds to destroy his apartment while Wilbur is on the line. Wilbur, thinking the call is just a prank, hangs up and continues on with his work day. Immediately thereafter, the actual Mr. McDougal (Frank Ferguson) shows up to claim the shipments and, fearing them damaged when Wilbur and Chick mishandle them, demands that the crates be delivered in person so his insurance agent can inspect them.
In New Orleans, Dylan Dog, an ace detective whose specialty is paranormal cases, narrates how he helped people with their cases until his wife, Cassandra, was killed by vampires. Since then he has been doing regular cases with his "partner", Marcus Deckler.