A bartender is working at a saloon, serving drinks to customers. After he fills a stereotypically Irish man's bucket with beer, Carrie Nation and her followers burst inside. They assault the Irish man, pulling his hat over his eyes and then dumping the beer over his head. The group then begin wrecking the bar, smashing the fixtures, mirrors, and breaking the cash register. The bartender then sprays seltzer water in Nation's face before a group of policemen appear and order everybody to leave.
The government develops genetically modified marijuana as part of the War on Drugs, and Norbert the Nark accidentally gives the prototype to the Fabulous Furry Freak Brothers. With the government on their trail, Phineas Freakears, Freewheelin' Franklin, and Fat Freddy are forced to leave town, acquiring a remote plot of land in order to fulfill their dream of retiring to grow marijuana in the country. Three women join the Freak Brothers' commune, but because gender politics have changed since the 1970s, they do not see eye to eye with the Brothers' free love philosophy.