In 2027, after 18 years of global human infertility, civilization is on the brink of collapse as humanity faces extinction. The United Kingdom, the only stable nation with a functioning government, is deluged by asylum seekers fleeing the chaos and war which have taken hold around the world. In response, Britain has become a militarized police state as British government forces round up and detain immigrants. Theo Faron, a former activist turned cynical bureaucrat, is kidnapped by the Fishes, a militant immigrants' rights group. They are led by Theo's estranged wife, Julian Taylor, from whom he separated after their son's death.
A race of extraterrestrials called Mimics has taken over continental Europe. In England, General Brigham, head of humanity's United Defense Force, orders Major William Cage, a public affairs officer with no combat experience, to cover the next day's amphibious assault in France. Cage objects to the dangerous assignment and threatens to blackmail Brigham to avoid it. Brigham has Cage arrested; Cage is knocked out trying to escape. He wakes in handcuffs at a forward operating base at Heathrow Airport and discovers he has been demoted to private, charged with desertion, and assigned to a combat squad named "J" squad under the command of Master Sergeant Farell.
Okuyama's face was disfigured in an industrial accident, and his face is completely covered in burns; he wears bandages to cover them. He visits Dr. Hira, a psychiatrist who is able to fashion a "mask" for Okuyama to wear which is indistinguishable from the face on which it is modeled.
On a stormy night, Percy Bysshe Shelley (Douglas Walton) and Lord Byron (Gavin Gordon) praise Mary Shelley (Elsa Lanchester) for her story of Frankenstein and his Monster. Reminding them that her intention was to impart a moral lesson, Mary says she has more of the story to tell. The scene shifts to the end of the 1931 Frankenstein.
In a European village Henry Frankenstein, a young scientist, and his assistant Fritz, a hunchback, piece together a human body, the parts of which have been collected from various sources. Frankenstein desires to create human life through electrical devices which he has perfected.
The commercial opens with a dystopic, industrial setting in blue and grayish tones, showing a line of people (of ambiguous gender) marching in unison through a long tunnel monitored by a string of telescreens. This is in sharp contrast to the full-color shots of the nameless runner (Anya Major). She looks like a competitive track and field athlete, wearing an athletic "uniform" (red athletic shorts, running shoes, a white tank top with a cubist picture of Apple’s Macintosh computer, a white sweat band on her left wrist, and a red one on her right), and is carrying a large brass-headed hammer. Rows of marching minions evoke the opening scenes of Metropolis.
As part of an expedition from Earth on the ship "Pegas", Captain Zelyonyy, Professor Seleznyov and his daughter Alice Selezneva search for new animal species for Moscow Zoo. On the advice of the archeologist Gromozeka they look for with the help of doctor Verkhovtsev, the director of the museum of Two Captains, but the doctor behaves suspiciously: doesn't show them diaries of captains and starts spying on the expedition. On the planet Blukthey make some valuable purchases, among them a Chatterer — the bird belonging to the missing captain Kim. A suspicious fat man, Merry Fellow U, tries to steal a bird. Having listened to the speech of the Chatterer, the crew of "Pegas" heads for system of the Jellyfish. On the road heroes rescue robots of the planet of Shelezyak from diamond dust, admixed in greasing.
Makoto Konno, who enjoys playing baseball, lives with her parents and younger sister Miyuki in the Shitamachi area of Tokyo, Japan. Her aunt Kazuko Yoshiyama, is an art restorer at the Tokyo National Museum.
In the near future, a revolutionary new psychotherapy treatment called dream therapy has been invented. A device called the "DC Mini" allows the user to view people's dreams. The head of the team working on this treatment, Doctor Atsuko Chiba, begins using the machine illegally to help psychiatric patients outside the research facility, using her alter-ego "Paprika", a sentient persona that she assumes in the dream world.
In the distant future, the gargantuan blue humanoid Draags have brought human beings (who are called Oms as a play on the French word for "man", Homme) from Earth to the planet Ygam, where they maintain a technologically and spiritually advanced society. They consider them animals, and while some Oms are kept as pets by Draags, others live in the strange wilderness and are periodically slaughtered by the Draags who wish to keep their population controlled. Draags have much longer lifespans than Oms, but reproduce much less.
Psychiatrist Dr. Hill is called to the emergency room of a hospital, where a screaming man is being held in custody. Dr. Hill agrees to listen to his story. The man identifies himself as doctor, and he recounts, in flashback, the events leading up to his arrest and arrival at the hospital:
At the Institute for Cybernetics and Future Science ("Institut für Kybernetik und Zukunftsforschung, IKZ"), a new supercomputer hosts a simulation program that includes an artificial world with over 9,000 "identity units" who live as human beings, unaware that their world is just a simulacron. Professor Vollmer (Adrian Hoven), who is technical director of the program, is apparently on the verge of an incredible secret discovery. He becomes increasingly agitated and anti-social before dying in a mysterious accident. His successor, Dr. Fred Stiller, has a discussion with Günther Lause, the security adviser of the institute, when the latter suddenly disappears without trace, before passing on Vollmer's secret to Stiller. More mysterious still is the fact that none of the other IKZ employees seem to have any memory of Lause.
On a snowy night, a mysterious stranger, his face swathed in bandages and his eyes obscured by dark goggles, takes a room at The Lion's Head Inn in the English village of Iping in Sussex. The man demands that he be left alone. Later, the innkeeper, Mr. Hall (Forrester Harvey) is sent by his wife (Una O'Connor) to evict the stranger after he makes a huge mess in his room while doing research and falls behind on his rent. Angered, the stranger throws Mr. Hall down the stairs. Confronted by a policeman and some local villagers, he removes his bandages and goggles, revealing that he is invisible. Laughing maniacally, he takes off his clothes, making himself completely undetectable, and drives off his tormenters before fleeing into the countryside.
In April 2054, Washington, D.C. has a special police force called PreCrime that stops murderers before they act. Murders are predicted using three Precogs, mutated humans who "previsualize" crimes by receiving visions of the future. Over the past six years, PreCrime has successfully reduced the city's murder rate to zero, and the Federal government is on the verge of adopting it, even though the public finds it controversial. Captain John Anderton (Tom Cruise), the head of PreCrime, has been suffering from drug addiction since the unresolved disappearance of his son, Sean, which led to his wife, Lara (Kathryn Morris), divorcing him. With PreCrime poised to go nationwide, the system is being audited by Danny Witwer (Colin Farrell), an agent from the United States Department of Justice. In the middle of the audit, the Precogs generate a new prediction, one saying that Anderton will murder a man named Leo Crow in thirty-six hours. Anderton does not know Crow, but flees the area as Witwer begins a manhunt.
Scott Carey (Grant Williams) is a businessman who is on vacation with his wife Louise (Randy Stuart) on a boat off the California coast. When Louise goes below deck momentarily, a large, strange cloud on the horizon passes over the craft, leaving a reflective mist on Scott's bare skin. Louise is slightly alarmed when she comes above deck, and the two are puzzled by the phenomenon that disappears as quickly as it had it shown up.