During the Prohibition era, 13-year-old Lila Lee (Cheryl Smith) is summoned by letter to visit her injured father, a gangster, before he dies. She runs away from the Reverend (Blackburn), who has raised her and in whose church she has become well known as a singer, though her extraordinary beauty is beginning to attract attention as well. She ends up taking a bus to the strange town of Astaroth, where people have the "Astaroth Look."
After inheriting a 12th-century castle which belonged to a famed Duchess, John Reilly and his family, including his wife Susan and their blind teenage daughter Rebecca, travel to Italy to live. Susan blames him for the death of their son in a drunk driving accident which killed his five-year-old son and cost their daughter her eyesight.
The film opens outside the Winthrop house from the first film, only this time it is swarming with police officers and medical technicians. Howard is being wheeled into an ambulance because he has three deep gashes in his chest, Tanya is put into a police car, and Randolph is carrying Joshua Winthrop's book of spells, which he gives to Howard for safe keeping. Randolph confronts the Dean of the university about the house, who tells him not to dabble in things that he could never understand. Then Randolph goes to Professor Warren, who agrees to help.
Two romantic couples, consisting of four teenagers, decide to spend a weekend together located in a remote cabin found in the woods. An unseen force stalks and watches the group without their knowledge. Ellen (Ellen Sandweiss) and her boyfriend Bruce (Bruce Campbell) enter the woods to have a picnic lunch. The other couple, Scotty (Scott Spiegel) and Shelly (Mary Valenti), remain at the cabin playing Monopoly to pass time. During their lunch, Bruce announces to Ellen that they're camping on an Indian burial ground. Ellen is concerned, but Bruce assures her that they will be fine as long as they don't disturb the graves of the dead. Bruce then explores the area and discovers an ancient dagger belonging to the Indians. Ignoring his own advice, he takes the dagger with him.
Eight months after the events of Re-Animator, Doctors Herbert West and Dan Cain are working as medics in the middle of a bloody Peruvian civil war. In the chaos of battle and with plenty of casualties to work on, they are free to experiment with West's re-animation reagent. When their medical tent is stormed by the enemy troops, West and Cain return home to Arkham, Massachusetts. There, they resume their former jobs as doctors at Miskatonic University Hospital, and West returns to the basement laboratory of Cain's house to continue his research.
Ward stars as 1948 hardboiled private detective H. Philip Lovecraft, in a fictional universe where magic is real, monsters and mythical beasts stalk the back alleys, zombies are used as cheap labor, and everyone—except Lovecraft—uses magic every day. Yet, cars, telephones and other modern technology also exist in this world.
Ex-con John Martense (Blake Adams) returns to his childhood home of Lefferts Corner after serving time for a crime he didn't commit. Martense visits family friend Knaggs (Vincent Schiavelli), a mortician who has been holding half of a map for him. The map leads to a graveyard where Martense's father hid the money from his last heist. Arriving at an abandoned church, Martense is confronted by Cathryn (Ashley Laurence), a young woman seeking revenge for the murder of her sister, and town doctor Dr. Haggis (Jeffrey Combs). This group is quickly joined by a trio of criminals who are looking to find the money John's father stole from them. What everyone is not aware of are the humanoid creatures lurking underneath the holy grounds.
Following a violent storm, a small campsite in the Southern states is found littered with mutilated bodies. Journalist Clint Harrison investigates and learns of a family called the Dansens who kept a terrible secret. Resolving to get to the bottom of things, Harrison and his buddies decide to spend the night in the abandoned Dansen home with the result that there are more deaths, and Harrison finds out a terrible truth: he is related to the Dansens.
Hopper stars as 1950s hardboiled private detective H. Phillip Lovecraft, in a fictional universe where magic is real, monsters and mythical beasts stalk the back alleys, zombies are used as cheap labor, and everyone—except Lovecraft—uses magic every day. Yet, cars, telephones and other modern technology also exist in this world.
John (Roy Dupuis) and Kathleen (Kristin Lehman) Strauss are a couple attempting to uncover the secret to John's rare blood disease. Along the way, they encounter Dr. Marlowe (Rutger Hauer), who is intrigued by the case. Little do they know that the island which they are about to set foot upon is home to the Van Dam family, mutant-like creatures who have become deformed and bloodthirsty from centuries of inbreeding. Their mutation began with their relative Eva Van Dam, who had an incestuous relationship with her twin brother. Also, they are fully functioning hermaphrodites, capable of reproducing with themselves. They need to survive on (dead or alive) human flesh.
In the 1920s, impoverished horror writer Randolph Carter rents a room from Mrs. Caprezzi, an elderly land lady. Not long after settling into the shabby and almost bare room, he discovers a pool of ammonia on the floor that has leaked down from the room above. Mrs. Caprezzi, while cleaning up the ammonia, regales Randolph with strange stories of Dr. Muñoz (Jack Donner), the eccentric old gentleman who lives in the room upstairs. Later, Randolph suffers a heart attack and painfully makes his way to the doctor's room where he is treated with an unconventional medicine and makes a remarkable recovery. Befriending the doctor, Carter soon discovers the awful truth about the doctor's condition, why his room is kept intensely cold, and the fragile line that separates life and death.
The film opens with a dream sequence in which stock market tycoon Paul Marsh discovers a mermaid with razor sharp teeth while scuba diving into a carven pit. Paul awakes on a boat off the shores of Spain, where he is vacationing with his girlfriend, Barbara, and their friends Vicki and Howard. A sudden storm blows their boat against some hidden rocks. Vicki is trapped below deck, and Howard stays with her while Paul and Barbara take a lifeboat to the nearby fishing village of Imboca. During their absence, an unseen creature from the deep attacks the two in the boat.
For the past 13 years, Dr. Herbert West (Jeffrey Combs) has been serving a prison sentence due to a murder at the hands of one of his zombies. With what scant supplies he has on hand in the prison medical center, Dr. West has been capable of performing only extremely basic experiments on rats. However, his lack of supplies does not prevent him from uncovering a key element in his re-animation process. Dr. West has discovered "NPE" (Nano-Plasmic Energy), an energy that can be extracted from the brain of a living organism through an electrocution-like process, to be stored in a capsule resembling a small light bulb. The capsule can then be connected to a corpse and used in conjunction with West's previously developed reagent to restore the former dead to a lifelike state. The NPE prevents the degeneration seen in previous instances, where the reanimated are nothing more than mindless zombies. Used together with the re-agent, reanimated corpses regain their skills, memories, and motor functions and nearly fully resemble normal humans.
The film adheres very closely to Lovecraft's story, but there are a few changes. The sailors aboard the Emma first encounter the Alert abandoned at sea, rather than crewed by Cthulhu cultists and taken over by Emma 's crew after a violent confrontation as in the original story. Additionally, the film depicts the narrator present at the time of his great-uncle's death, who dies peacefully in his sleep, rather than being summoned upon the mysterious death of his great-uncle, who was presumably killed by Cthulhu cultists in the original short story. The narrator (Matt Foyer) notes as well that Inspector Legrasse, who had directed the raid on cultists in backwoods Louisiana, had died before the narrator's investigation began.