Mr. Quincy Magoo (Leslie Nielsen), a wealthy canned vegetable factory owner, goes to the museum to attend a party. While there, Waldo (Matt Keeslar), Mr. Magoo's nephew, spies a woman named Stacey Sampanahoditra (Jennifer Garner), whom he develops a crush on. Later that night, jewel thieves Luanne LeSeur (Kelly Lynch) and Bob Morgan (Nick Chinlund) steal the museum's beautiful ruby "The Star of Kuristan" and escape on a boat to Austin Cloquet (Malcolm McDowell), Bob's boss.
Brigitte, Danielle, Hedwige, Bertrand et Saïd ont perdu la vue à différents stades de leurs vies. Pour eux, à quoi ressemble le monde qui les entoure ?