In the year 10,001 B.C., a caveman runs away from a predator through a plain and immediately gets into a fight with Wolf (Ike Barinholtz). After defeating him, the caveman then encounters the predator: a saber-toothed, gasoline-drinking Amy Winehouse (Nicole Parker), who after checking her Facebook account, informs him that the world will end on August 29, 2008 (the film's release date) revealing that their fate lies in a crystal skull. The film flash-forwards to the present, treating the first scene as a dream sequence of Will (Matt Lanter). He then finds out that his girlfriend Amy (Vanessa Minnillo) is having an affair with Flavor Flav (Abe Spigner), and she breaks up with Will because he is not admitting his true feelings for her.
In the Arctic waters near the Helheim Glacier in Greenland, a person is surfing on waves created by falling chunks of ice that fall off the glacier and into the ocean caused by the effects of global warming. However, a very large chunk of ice falls into the water, creating an especially large wave. The surfer tries to escape from the wave, but it is far too fast for him, and in a matter of seconds, it catches up to him then drowns and kills him instantly.
Deux frères, Jimmy et Kamango, tentent de survivre à une catastrophe planétaire. Des « choses » ont envahi le monde. Elles se nourrissent d'êtres vivants, y compris d'êtres humains. Les deux frères logent désormais dans l'appartement d'un ancien militaire, Kuter, toujours accompagné de son garde du corps. Alors que les deux frères rêvent de partir en direction du sud, une femme muette fait irruption dans leur vie…