During a solar eclipse in 1986, young Naina Shah, while traveling in the backseat of her England-based dad's car, is struck by glass from the shattered windshield during an accident, and loses her eyesight. Her parents do not survive, and she is brought up by her paternal grandmother. Years later, Naina gets a successful cornea transplant, and is able to see. She complains of vision problems, seeing hooded persons, and people dying, which a psychiatrist, Samir Patel, diagnoses as hallucinations. But when Naina reports seeing someone else in her mirror reflection, Sameer decides to investigate who the original cornea actually belonged to. This investigation will lead them to an impoverished village in New Bhuj, Gujarat, where she will find her life endangered by hostile villagers who believe that the donor of her cornea was cursed.
After Robocop 2, Detroit is on the verge of bankruptcy after a series of failed business plans and drop of stocks, and are now struggling with their plans to create the new Delta City. To speed up the process, OCP creates an armed force called the Urban Rehabilitators, nick-named "Rehabs," under the command of Paul McDaggett (John Castle). Ostensibly its purpose is to combat rising crime in Old Detroit, augmenting the ranks of the Detroit Police Department in apprehending violent criminals. In reality, it has been set up to forcibly relocate the residents of Cadillac Heights. Nikko, a Japanese-American computer whiz kid, loses her parents in the process.
Mr. Quincy Magoo (Leslie Nielsen), a wealthy canned vegetable factory owner, goes to the museum to attend a party. While there, Waldo (Matt Keeslar), Mr. Magoo's nephew, spies a woman named Stacey Sampanahoditra (Jennifer Garner), whom he develops a crush on. Later that night, jewel thieves Luanne LeSeur (Kelly Lynch) and Bob Morgan (Nick Chinlund) steal the museum's beautiful ruby "The Star of Kuristan" and escape on a boat to Austin Cloquet (Malcolm McDowell), Bob's boss.
On his way home from a party, James Fhelleps is involved a car crash that kills his daughter Heather, and leaves his wife Alice disfigured, paralyzed and catatonic. While James aimlessly wanders the city, Alice is cared for by Barry, a coprophilic physical therapist who sexually abuses her. One day, James gives a prostitute named Emmy Bruzze a lift to her house, where James experiences a psychotic break when Emmy tries to seduce him, resulting in him killing her. As James stares at Emmy's body in shock, it begins speaking to him in Heather's voice, begging for help and claiming that God is keeping her from him. James returns home, gets rid of all religious objects in the house, and holds a conversation with Alice, who he is convinced communicates with him telepathically.
Alex Shaw is on a motorcycle chase after a vehicle with stolen goods. He eventually catches the driver of the vehicle, but his girlfriend Annie runs into him during her driving test. She finds out that Alex is on the SWAT team after he lied and told her he was a beach cop. As an apology, Alex surprises her with a Caribbean cruise on Seabourn Legend.
Redheaded twins Anna (Nikki Haddad) and Sarah (Jessi Haddad) Woodruff, roughly 10 or 11 years old, both have Asperger, an autism spectrum disorder (ASD), and Sarah is going blind. Child psychologist and researcher Dr. Reineger (Edmund Gildersleeve) tries to assure their parents (Courtney Sanford, Travis Poelle) that the kids are smart and "intricately involved in their own imagination". The children enter an institute to be studied, two family tragedies occur, and the girls escape the institution. Throughout much of the film, we see a magical, distorted world through their eyes.
Unable to bring in anymore money for Leroy, her abusive pimp, the pregnant Rose tries to run away in the middle of the night, but is caught by Leroy. Using a clothes hanger, Leroy performs an impromptu abortion on Rose, unintentionally killing her in the process. Leroy disposes of Rose's baby in a dumpster, where its cries attract the attention of a homeless man, who raises the disfigured child as "Hanger".
The quiet suburb of New Salem is being terrorized by a serial killer who abducts and tortures young women, holding them captive for weeks before murdering them. Aubrey Fleming (Lindsay Lohan), a pianist and aspiring writer, appears to be his latest victim when she disappears during a night out with her friends. She is later seen bound and gagged on an operating table as her hands are exposed to dry ice. As the days tick by, the special FBI Task Force convened to track the killer begins to lose hope of finding her before it's too late.
Harpooner Ishmael (Corey Sevier) joins Ahab (Danny Glover) and his crew on the Pequod, in this instance an armored land boat that hunts for dragons. The seven-strong crew ostensibly seeks the precious "vitriol", a highly explosive liquid substance found inside the fire-breathing winged creatures, which powers the mythical realm they live in. Ishmael joins their quest, and soon learns that in fact, Ahab's mission is one of revenge on a particular great white dragon that decades ago scarred and injured him, and also killed his sister. Forced to hide from the sunlight due to the burn wounds on his body, Ahab now tries to kill all dragons, and especially the white one. Conflict arises through a romantic entanglement between Ishmael and Ahab's adopted daughter, Rachel (Sofia Pernas), which causes hostility from the jealous hothead Flask (Larry Bagby). In the white dragon's lair, Ahab's secrets are revealed and Rachel must choose between following him on his dark quest or escaping to a new life with Ishmael. She chooses the latter and in a final confrontation, Ahab's spear, which was tied to his foot, becomes entangled in the White Dragon's neck. The creature flies off with a screaming Ahab, until he is slammed against a rock pillar and silenced. The white dragon flies off into the distance, with Ahab's body clinging on to it.
A NASA spacecraft has landed on an unknown planet and begins to take rock and soil samples. Four aliens discover it and are sucked up through its vacuum, after which it makes its way back to Earth. The aliens are able to escape from a military base by using their powers (with which they can destroy or heal anything they touch). During the escape, the youngest one hides in a passing van, occupied by a wheelchair-bound boy named Eric Cruise, his older brother, Michael, and their single mother, Janet, who are moving to California from Illinois.
A female mental patient (Patsy Kensit) believing she is the reincarnated soul mate of Jack the Ripper, terrorizes her psychiatrist (Patrick Muldoon), whom she believes is her reincarnated lover. Determined to find her man, and willing to use her sensuality to get to him, she breaks out of the mental institution and is determined to, at any cost, free him of his wife (Amy Locane) and young daughter to restart their previous work as mass murderers, and lovers.
Jessicka (Elske McCain) is a mute and mentally challenged young woman that lives with her cousins Marley (Trent Haaga) and Brad Hoffman (Jeff Sisson). They mistreat and abuse her on a regular basis, subjecting Jessicka to beatings and rape when they aren't locking her up in a dog cage and treating her like a pet. It's only after Jessicka is bitten by a rabid dog that she begins to turn on her cruel captors and the porn director they pimp her out to.
At a lake, the mentally handicapped Nina spots her brother Jacob, his girlfriend Jamie, and their friends Tony and Sammy skinny dipping. Nina follows Jacob and Jamie into the woods, observes them having sex, and is dragged off by Tony and Sammy. When Jacob and Jamie finish, Jamie goes off alone, and is chased by a man who has murdered Tony and Sammy. The man drowns Jamie in the lake, while Jacob (who was looking for Nina) watches in shock. Jacob goes to the police station, where he tells the chief that he received a call from his father, Willy, who he thinks has committed suicide.
During routine administration at the Lyndon B. Johnson Space Center, Dr. Rhodes discovers that a comet has suddenly veered off its orbit and smashed into Mars. The explosion causes debris to travel towards Earth with the possibility of causing an extinction level event. At Ben Marshall's house, Ben refuses to give his son, Leo, a ride as he complained his own car smelled of mildew. However, Ben drives Leo to school and discovers Leo is in love with a fellow student, Lindsey. Leo is chatting with Lindsey when her ex-boyfriend, Sean, gives them threatening looks.