Deux petites souris, habillées comme des Indiens (dont une avec une plume bleue, l'autre avec une plume rouge) marchent vers la maison de Jerry. Ils frappent à la porte et lui remettre une note qui se lit: "Cher chef scout Jerry. "Ce sont les deux petits orphelins que vous avez promis de prendre pour faire une randonnée. Merci"...
Mickey est aux commandes de sa propre radio amateur, nommée ICU (I See You) et émise depuis sa grange. Minnie et quelques amis l'aident en jouant des morceaux. La musique attire un chat qui décide de miauler dans le micro. Pluto qui écoute depuis sa niche part à sa poursuite. Mickey chasse le chat mais d'autres félins s'attaquent aux équipements radiophoniques puis courent à travers les musiciens poursuivis par Mickey, armé d'un balai, et par Pluto. La cavalcade génère beaucoup d'actions.
Donald is a plumber fixing pipes in the basement of a house (presumably Mickey's house, since Mickey is mentioned on the title cover of the episode). Donald first has trouble with pulling his hammer off a magnet, which it gets stuck to. When he unscrews the lid covering the pipe, water spurts out and hits Donald in the face, angering him. To stop the flow, Donald uses the magnet to pull a larger hammer toward himself, which he uses to put on another lid to the hole. In doing so he accidentally wakes Pluto and later accidentally pulls Pluto's bone away from him. While Pluto wrestles with the magnet to get his bone back, he swallows the magnet and gets his bone stuck to his bottom. As he fights to get the bone, he tumbles into the pile of furniture Donald is standing on, causing Donald to come crashing to the ground. Pluto eventually runs into the kitchen and the magnet inside him causes many cooking items to be pulled onto his rear.
En Espagne, un chat espagnol est plus intéressé à jouer de la guitare flamenco que d'essayer d'attraper la souris El Magnifico (Jerry).
La maîtresse de maison fait venir le champion du monde de capture de souris des USA qui n’est autre que Tom.
Celestine is a young mouse who lives in the underground world of rodents. At the orphanage where she lives, the caretaker known as the Gray One tells scary stories about the evil nature of the bears that live in the outside world, though Celestine doubts they are entirely true. She loves to draw but must soon study dentistry, since that's what all rodents do, and to prepare, she must travel above ground to collect bear cubs' lost teeth from underneath pillows. On one such occasion, the cub's family catches Celestine in the act and chase her into a trash can where she is trapped and spends the night. The next morning, a destitute and starving bear named Ernest discovers Celestine and attempts to eat her. Celestine convinces him to let her go by helping him break into the basement of a candy shop, where he can eat his fill. He is soon caught by the store's owner, however, and arrested. Celestine, who is behind on her quota of collected teeth, agrees to free him from the police wagon if he will help her break into and rob the teeth from the office of the store owner's wife, who happens to be a dentist.
Jasper s'amuse à terroriser Jinx. Lorsque ce dernier s'accroche à la moustache de Jasper, il lui met le doigt dans l'œil. Jasper se met à poursuivre Jinx mais brise par accident une statue. Sa maîtresse « Mammy Two Shoes » (voix originale : Lillian Randolph) le menace alors de le jeter dehors s'il brise un autre objet. Lorsque la souris se moque de lui, Jasper essaye de le pourchasser mais Jinx lui menace de jeter un verre s'il le prend dans ses mains. Jasper recule, ayant peur de se faire jeter dehors. Mais Jinx jete quand même le verre et Jasper, heureusement, le rattrape. Mais la souris lance également un plateau, d'autres verres et un vase que le chat réussit à rattraper. Jasper imagine alors une stratégie : mettre des coussins sur le sol pour pouvoir attraper Jinx sans se faire jeter dehors. Une nouvelle course-poursuite se produit dans le salon. Mais Jinx fait porter à Jasper un tas de vaisselles puis finit par jeter une assiette que Jasper ne rattrape pas. Le chat finit alors par se faire jeter dehors par sa maîtresse comme menacé au début du cartoon.
Le film est composé de sept séquences illustrant huit morceaux de musique classique, réorchestrés et dirigés par le chef d'orchestre Leopold Stokowski à la tête de l'Orchestre de Philadelphie. La dernière séquence illustre deux morceaux et un intermède sépare la séquence 4 et 5. Chaque séquence est précédée d'une courte introduction où l'orchestre est en ombre chinoise.
Several years after settling in to their new home in The Bronx, New York, the impoverished Mousekewitz family soon finds that conditions are not as ideal as they had hoped, as they find themselves still struggling against the attacks of mouse-hungry felines. Fievel spends his days thinking about the wild west dog-sheriff Wylie Burp, while his sister, Tanya, dreams of becoming a singer. Meanwhile, Tiger's girlfriend Miss Kitty leaves him to find a new life out West, remarking that perhaps she's looking for "a cat that's more like a dog."
Fievel, his friend, Tony and his sister, Tanya all get jobs at the local newspaper, where the audience is introduced to Nellie, who wants to be an important reporter, but only gets small assignments, as if she were a secretary to Reed, the newspaper's editor. Throughout the film, Tanya tries to win Reed's heart, while Tony tries to get noticed by Reed and promoted to a reporter. Like in the previous movies, where a mouse installation is directly below its human installation counterpart, the newspaper offices the mice work in is directly underneath the newspaper offices the humans work in.
The story starts off in New York City setting sometime after the first movie (which began in 1885) presumably between 1886 and 1889, as Fievel and Tony discover that an ancient treasure lies underneath Manhattan when snooping around an abandoned subway (the Beach Pneumatic Transit system) and stumbling upon the remains of a dead mouse clutching a treasure map, deciding they must find it with the help of an archaeologist Tony knows: Dr. Dithering, along with fighting five villains as well.
Chez Minnie, le chat Figaro cherche à attraper Frankie le canari dans sa cage. Comme Minnie ne voit plus l'oiseau, elle pense qu'il est parvienu à l'attraper. Mais Frankie s'était caché et s'enfuit par la fenêtre tombant alors entre les crocs de Butch le bouledogue. Figaro se bat contre sa conscience ayant alors pris une certaine subsistance et part sauver le canari... après une lutte avec le chien, Minnie remercie Figaro d'avoir sauvé Frankie.