The film follows Max Parry (Kevin Howarth), a disturbed wedding video cameraman, and his unnamed assistant (Mark Stevenson) as they perform several murders that they have videotaped. The two have used a video store tape in order to record the proceedings, breaking the fourth wall and insinuating that the copy of the film being watched is the only existing version of the tape. Throughout the film Max uses meta-references in order to show off his gruesome activities as a serial killer. The film raises questions surrounding visceral pleasure, this can be seen in one scene in particular during which the audience cannot see the victims (two at once) being murdered, Max Parry then asks the audience "I bet you wanted to see that, and if you didn't, why are you still watching?"
The story follows five contestants who agree to take part in a reality webcast. The rules are simple: "Spend 6 months in a house for $1 MILLION. If someone leaves, everyone loses!" With the end of the 6 months nearing, the tension between contestants Matt (Sean Cw Johnson), Emma (Laura Regan), Charlie (Jennifer Sky), Danny (Stephen O'Reilly) and Rex (Kris Lemche) is at a high level. Instead of their regular food deliveries, packages containing sinister object arrive. A letter stating that Danny's grandfather has died, a gun with 5 bullets and a bottle of champagne.
Tyler is obsessed with the film, considered being the scariest movie ever made, with the deranged serial-killer Babyface in the lead role. However, the director, Wilson Wyler Concannon, and the movie vanished many years ago and there is no known copy. When Tyler discovers that Concannon's daughter Alexa works in a night club, he decides to meet her and ask about the lost film. Tyler's obsession with the film causes him to neglect his girlfriend Serena. He visits Alexa, who works as a stripper, and asks her about the project. As she gives him a nude lap dance, the audience sees Serena cheating on Tyler with their best friend Lalo. After Tyler helps Alexa with her addiction to heroin, she tells him that the movie might be in her father's home in the woods.
A man, known only as "The Counselor", and his girlfriend Laura are talking sexily in bed. Meanwhile, somewhere in Mexico, cocaine is packaged in barrels and concealed in a sewage truck, driven across the border and stored at a sewage treatment plant.
Unsuspecting couple Steve and Rachel become completely immersed in a town of blood-drunk crazies. Led by sickos Howard and Eli, these backwater psychopaths produce and watch their own snuff movies in which the victims are outsiders or citizens trying to leave the close-knit community of killers. One day an unmarked tape shows up in the return bin of Steve's just-opened video store, and it's the town postmaster being savagely mutilated. "Can it be real, or just a gag?" wonders Steve. He'll soon discover the horrifying answer...
The film opens with a family being hung up like scarecrows in a corn field with sacks over their heads and burned alive. It is revealed to be the nightmare of nine-year-old Dylan Collins, who is staying in a rural farmhouse with his twin brother Zach, and their mother Courtney (Shannyn Sossamon).
A young woman with amnesia breaks out of a coffin in a funeral home, and dials 911 in the morgue, but accidentally unhooks the telephone while speaking to the operator. The mortician appears, and is impaled by a man equipped with a chrome skull mask, and a shoulder mounted camera. The girl stabs ChromeSkull in the eye, and runs off while he treats his wound. The girl is picked up by Tucker, who takes her home to his wife Cindy, and promises her that they will go to the sheriff's station in the morning, as Tucker's truck is low on gas, and their phone service has been cut off.
Keri Russell plays Katie Armstrong, an American student in Germany studying criminal psychology. She chooses a notorious subject for her thesis: the cannibal killer Oliver Hartwin (played by Thomas Kretschmann). Oliver dreamed of eating a willing victim, and thanks to the internet, he was able to find a volunteer, a young man Simon Grombeck (played by Thomas Huber).
Terry Hawkins (Watkins) has just been released after spending a year in state prison on drug charges. He wants to get into filmmaking, and claims he previously made stag films that he was unable to sell. Terry believes audiences want something more, so he decides to make snuff films.
In the intro, a mother reads the story of Hansel and Gretel to her young boy. The setting then moves to the present day, where The Man goes about his day-to-day routines and occasionally chats with others on his computer, where he looks for someone who shares his cannibalistic fantasies. The Man meets with several people he had chatted with, but he either rejects them or is rejected (and in one case attacked) by them, except for The Flesh, a suicidal man who volunteers to be killed and eaten by The Man. The Flesh travels to The Man from Berlin, and the two bond, having sex and frolicking in the nude in and around The Man's home.
Semi-retired porn star Miloš (Srđan Todorović) lives with his wife, Marija (Jelena Gavrilović), and six-year-old son, Petar (Luka Mijatović). His brother, Marko (Slobodan Beštić), a corrupt police officer, is attracted to Marija. Marija is curious about her husband's past and is concerned about the family's income. Lejla (Katarina Žutić), a former co-star, offers Miloš a starring role in an art film directed by Vukmir (Sergej Trifunović), an independent pornographer, who wishes to cast Miloš for his powerful erection. Having already caught Petar watching one of his films and unaware of the details of Vukmir's film, Miloš is hesitant to participate and continue his career, but accepts to secure his family's financial future. While meeting Vukmir, Miloš passes a bald man and his entourage, regarding them warily.
The minions of serial killer Jesse "ChromeSkull" Cromeans locate their employer and bring him back from the brink of death, though the injuries he sustained have left him disfigured. As ChromeSkull recuperates, tended to by an assistant named Spann, his disgruntled second-in-command, Preston, tracks Princess and Tommy, the survivors of the previous film, to a motel. Preston kills Princess, which infuriates ChromeSkull, while Tommy is spared, due to being out at the time of Preston's attack.