Remy (Nick Swardson), Augie (T.J. Miller), and Curt (Rob Riggle) are best friends since birth. When they jokingly take a blood oath and break it, Curt is dragged to Hell to be sacrificed. Remy and Augie must save Curt from a slew of misfit demons, Greek legends, and the Devil (Bob Odenkirk) himself.