Alice Racine est une ancienne interrogatrice de la CIA. Traumatisée par un échec professionnel deux ans plus tôt, elle a préféré se retirer. Bob Hunter, son ancien directeur, la contacte pour déjouer une attaque imminente sur Londres. Elle est chargée d'interroger un homme suspecté d'être le messager de terroristes djihadistes. Pour appréhender son terrible adversaire, Alice reçoit l’aide de son ancien mentor, Eric Lasch, et d’un membre des forces spéciales, Jack Alcott. Trahie et manipulée, elle va rapidement s'apercevoir que l’agence a été infiltrée et va devoir déjouer cette conspiration.
A British couple, Perry (McGregor) and Gail (Harris), get embroiled with a Russian oligarch and high-profile money launderer Dima (Skarsgård) while on holiday in Marrakech. Dima leads them into a tortuous journey through Paris, the Swiss Alps and London.
On a mission in Mexico, unofficially ordered by the previous M, James Bond kills two men arranging to blow up a stadium; in doing so the building they are in explodes and collapses. Bond gives chase to Marco Sciarra, who survived the blast; Sciarra boards a helicopter to escape. Bond follows and in the ensuing struggle he throws both Sciarra and the pilot out of the helicopter, stealing Sciarra's octopus ring as he does so. On his return to London Bond is indefinitely taken off field duty by the current M, who is in the midst of a power struggle with C, the head of the Joint Intelligence Service, which consists of the recently merged MI5 and MI6. C also wants to create the "Nine Eyes" intelligence co-operation agreement between nine countries, and close down the '00' section in the process.
In 1963, professional thief turned CIA agent Napoleon Solo extracts Gaby Teller, daughter of Udo Teller, an alleged Nazi scientist turned United States collaborator at the end of World War II, from East Berlin, evading KGB operative Illya Kuryakin. He later reports to his superior, Saunders, who reveals that Teller’s uncle Rudi works in a shipping company owned by Alexander and Victoria Vinciguerra, a wealthy couple of Nazi sympathizers who intend to use Teller's father to build their own private nuclear weapon. Due to the potentially world-ending nature of this crisis, the CIA and KGB have reluctantly teamed up and Solo and Kuryakin are ordered to stop the Vinciguerras from succeeding, with both men secretly assigned to steal Udo Teller's research for their respective governments.
During a raid in the Middle East, a probationary secret agent sacrifices himself to save his team. Feeling guilt over the loss of his colleague, Harry Hart, code-named "Galahad", delivers a bravery medal to the agent's widow, Michelle Unwin, and her young son, Gary "Eggsy", saying that if they ever need help, they should call the phone number on the back of the medal and deliver a coded message.
Set several years after the end of the TV series, Harry Pearce (Peter Firth) is still head of the counter-terrorism department (Section D) at MI5. Harry's team is transporting apprehended terrorist Adem Qasim (Elyes Gabel) through London when the convoy is attacked, allowing Qasim to escape and a CIA operative to be killed. MI5 is humiliated in the press, and relations between British and American intelligence agencies are frayed. Realising that the CIA will demand a scapegoat and that he is soon to be decommissioned from MI5, Harry seemingly commits suicide by jumping off Lambeth Bridge into the Thames.
Susan Cooper (Melissa McCarthy) is a desk-bound CIA analyst guiding her partner Agent Bradley Fine (Jude Law) on a mission to Varna from a CIA office in the Washington, D.C. area. Fine kills Tihomir Boyanov after he sneezes without first finding a suitcase nuke whose location is known only to Boyanov. Meanwhile, the agency learns that Boyanov's daughter Rayna (Rose Byrne) might know the location of her father's device, so they send Fine to infiltrate her home. However, Rayna shoots Fine dead while Susan watches online. Rayna knows the identities of all the agency's top agents, including Fine and Rick Ford (Jason Statham). Susan, who is unknown to Rayna, volunteers to become a field agent, and her boss, Elaine Crocker (Allison Janney), agrees. Ford quits in disgust over Susan being chosen for the assignment.
After intercepting nerve gas being sold to terrorists, Impossible Missions Force (IMF) agent Ethan Hunt (Tom Cruise) is convinced he can prove the existence of the Syndicate, an international criminal consortium that the Central Intelligence Agency (CIA) does not believe exists. Hunt is captured by the Syndicate, but escapes a torture chamber led by Syndicate member Janik "Bone Doctor" Vinter (Jens Hultén) with the help of MI6 agent and Syndicate operative Ilsa Faust (Rebecca Ferguson).
In 1957 Brooklyn, New York, Rudolf Abel retrieves a secret message from a park bench and reads it just before FBI agents burst into his rented room. He prevents discovery of the message, but other evidence in the room leads to his arrest and prosecution as a Soviet spy.
Set in the 1930s during Japan's colonial rule of Korea, many Korean resistance activists are based in Manchuria, northeastern China while hiding from Japanese authorities. In 1933, orders are given to assassinate Kawaguchi Mamoru, the governor of the Japanese garrison in Gyeongseong, and Kang In-gook, a pro-Japanese Korean business tycoon. For this covert mission, Yeom Seok-jin, an agent of the provisional Korean government who had broken out of prison in 1911, is tasked to do the same for three people and bring them to Shanghai: topnotch sniper Ahn Ok-yun, who's in a Manchurian jail for shooting her superior; Chu Sang-ok (nicknamed "Big Gun"), one of the last graduates of the Independence Military School and in prison after stealing guns from Chiang Kai-shek's army then selling them; and Chu's cellmate Hwang Deok-sam, an explosives specialist imprisoned for selling faulty product. The squad arrives in Gyeongseong, not knowing that one of them is secretly working for the Japanese and has hired freelance assassin Hawaii Pistol and his sidekick Old Man to kill members of the team.
Issa Karpov (Grigoriy Dobrygin), a political refugee from Chechnya who has been tortured by Russian security forces, enters Hamburg, Germany, illegally.
After the terrorist attacks on 9/11, Jack Ryan (Pine), studying at the London School of Economics, becomes a U.S. Marine second lieutenant fighting in Afghanistan, where his spine is critically injured when his helicopter is shot down. During a lengthy recovery, he attracts the attention of Cathy Muller (Knightley), the medical student helping him learn to walk again, and Thomas Harper (Costner), an official with the CIA who recruits him.
Veteran CIA officer Peter Devereaux (Pierce Brosnan) supervises a young operative David Mason (Luke Bracey), and chides him for becoming intimate with a local woman. Relationships can be used against an agent, he says laying out a scenario forcing an agent to choose between the job and someone they love. Subsequently, in a mission to protect a US Ambassador in Montenegro. Devereaux, wearing Kevlar, impersonates the ambassador in a public square, drawing the fire of an assassin. Mason disobeys Devereaux's orders not to fire as the crowd is too close, and in shooting the assassin, Mason accidentally kills a child.