Gauri (Shobhana) the sole survivor of a tragic bus accident loses her memory. Admitted to a private nursing home, where she is diagnosed as suffering from 'hysterical amnesia' (retrograde amnesia), she falls in love with the doctor's son Sarath Menon (Jayaram). However, Narendran (Suresh Gopi), Gauri's husband arrives from USA searching for Gauri. When Gauri fails to recognise Narendran, he returns without a word, never showing Sarath his wedding photos with Gauri, that he was carrying with him.
The day of his fifth wedding anniversary, Nick Dunne returns home to find that his wife Amy is missing. Her disappearance receives heavy press coverage, as Amy was the inspiration for her parents' popular "Amazing Amy" children's books. Detective Rhonda Boney does a walkthrough of their house and finds poorly concealed evidence of a struggle. The police conduct a forensic analysis and uncover the remnants of cleaned blood stains, leading to the conclusion that Amy was murdered. Suspicions arise that Nick is responsible, and his awkward behavior is interpreted by the media as characteristic of a sociopath.
Two brilliant young aesthetes, Brandon Shaw (Dall) and Phillip Morgan (Granger), strangle to death a former classmate, David Kentley (Dick Hogan), in their apartment. They commit the crime as an intellectual exercise; they want to prove their superiority by committing the "perfect murder".
Rizwan Khan is a Muslim child who grew up with his brother Zakir and his mother Razia Khan in a middle-class family in the section of Mumbai. Rizwan is different from other children, however. He has certain gifts, particularly a special ability to repair mechanical things. His difference leads to special tutoring from a reclusive scholar and extra attention from his mother, both of which lead to heightened jealousy from his brother Zakir, who eventually leaves his family for a life in the United States.
The story may not be linear and exhibits several instances of temporal disruption. A dark-haired woman (Harring) escapes her own murder, surviving a car accident on Mulholland Drive. Injured and in shock, she descends into Los Angeles and sneaks into an apartment which an older, red-headed woman has just vacated. An aspiring actress named Betty Elms (Watts) arrives at the same apartment and finds the dark-haired woman confused, not knowing her own name. The dark-haired woman assumes the name "Rita" after seeing a poster for the film Gilda (1946), starring Rita Hayworth. To help Rita remember her identity, Betty looks in Rita's purse, where she finds a large amount of money and an unusual blue key.
Charlie (Logan Lerman) is uneasy about beginning his freshman year of high school; he is shy and finds difficulty in making friends, but he connects with his English teacher, Mr. Anderson (Paul Rudd).
Elwood P. Dowd (Stewart) is a middle-aged, amiable (and somewhat eccentric) individual whose best friend is an invisible 6' 3.5" tall rabbit named Harvey. As described by Dowd, Harvey is a pooka, a benign but mischievous creature from Celtic mythology who is especially fond of social outcasts (like Elwood). Elwood has driven his sister and niece (who live with him and crave normality and a place in society) to distraction by introducing everyone he meets to his friend, Harvey. His family seems to be unsure whether Dowd's obsession with Harvey is a product of his (admitted) propensity to drink or perhaps mental illness.
Under mysterious circumstances, Blanche DuBois, an aging highschool teacher, leaves her home in Auriol, Mississippi to travel to New Orleans to live with her sister, Stella Kowalski. She arrives on the train and boards a streetcar named "Desire" and reaches her sister's home in the French Quarter where she discovers that her sister and brother-in-law, Stanley Kowalski, live in a cramped and dilapidated two-room apartment in an old New Orleans tenement. Blanche and Stella are all that remain of an old aristocratic family. Blanche discloses that the family estate, Belle Reve, has been lost to creditors, and that she wants to stay with Stella and Stanley for a while. Blanche seems lost and broke, with nowhere to go. Stella welcomes her with an open heart.
The story takes place during a twenty-four hour period while four family members take their vacation on a remote island, shortly after one of them, Karin (Harriet Andersson), is released from an asylum where she has been treated for schizophrenia. Karin's husband Martin (Max von Sydow) tells her father, David, that Karin's disease is almost incurable. Meanwhile, Minus (Lars Passgård), Karin's 17-year-old brother, tells Karin that he wishes he could have a real conversation with his father and cries because he feels deprived of his father's affection. David (Gunnar Björnstrand) is a novelist suffering from "writer's block" who has just returned from a long trip abroad. He announces he will leave again in a month, though he promised he would stay. The others are upset and David gives them unthoughtful, last-minute presents. He leaves them and sobs alone for a moment. When he returns, the others cheerfully announce that they too have a "surprise" for David; they perform a play for him that Minus has written. David, while feigning approval of the play, takes offense since the play can be interpreted as an attack on his character.
Chance (Peter Sellers) is a middle-aged man who lives in the townhouse of an old, wealthy man in Washington, D.C. He is simple-minded and has lived there his whole life, tending the garden. Other than gardening, his knowledge is derived entirely from what he sees on television. When his benefactor dies, Chance naively says he has no claim against the estate, and is ordered to move out. Thus he discovers the outside world for the first time.
Drab Charlotte Vale (Bette Davis) is an unattractive, overweight, repressed spinster whose life is brutally dominated by her dictatorial mother (Gladys Cooper), an aristocratic Boston dowager whose verbal and emotional abuse of her daughter has contributed to the woman's complete lack of self-confidence. It is revealed that Mrs. Vale had already brought up three sons, and Charlotte was an unwanted child born to her late in life. Fearing Charlotte is on the verge of a nervous breakdown, her sister-in-law Lisa (Ilka Chase) introduces her to psychiatrist Dr. Jaquith (Claude Rains), who recommends she spend time in his sanatarium.
Dileep (Kamal Haasan) is a successful businessman with a dark side. He preys on nubile girls; tortures and kills them. These proceedings are video-recorded and watched by his adoptive father and mentor, another deranged woman-hater who, as with Dileep, had a disillusioning experience with the female sex in his past. The old man stays holed up in a far corner of Dileep's mansion watching his son carry out what he is too infirm to do. The murdered girls are buried in Dileep's garden and a rosebush is grown above.
The film opens in a church where a man named Francisco sees an attractive young woman from across the room. They have seen each other many times before, and she seems reluctant to engage him. She leaves the church and escapes Francisco, despite his attempt to chase after her. Another day, Francisco finds her again in the church. He works up the courage to speak with her, but she seems uninterested, and insists that they can never speak to each other again. Francisco follows her to a restaurant and sees her meeting with Raul, a close friend of his.