The film takes place in Australia and Vampire Rock, a rock formation shaped like a vampire head. There is a legend of a vampire named the Yowie Yahoo, who lives in the rock. The film starts at Vampire Rock where the "Vampire Rock Music Festival" is being set up. Many people are excited for it, but some don't think it should take place because it would anger the Yowie Yahoo. One such person is Malcolm Illiwara, even though his own grandson Daniel is the manager of the contest. One night, as Malcolm and his grandson watch a sure-to-win performer named Matt Marvelous, the Yowie Yahoo appears. The Yowie Yahoo and its three vampire minions capture Matt Marvelous and take him away. Everybody is scared, and Malcolm blames the contest for what happened.
The film begins with an introductory song by Tulie, a bayou dweller, who tells the story of Valdronya and the Mystery Inc. Gang. After solving the mystery of a Cockroach Monster that terrorized a factory, Fred, Daphne, Velma, Shaggy, and Scooby decide to take a much needed vacation. Velma drives everyone to Chauve Sourie Ville, a small town in Louisiana which is hosting a vampire festival called "Vampire Palooza." They meet Lita Rutland, the festival organizer, who explains that tourism is down and the festival is losing money. They also meet their host, Vincent Van Helsing, who runs a vampire museum and is an aspiring author, although his books are not selling. Jesper Poubelle, an anti-vampire agitator, is also stirring up trouble by protesting the festival. Van Helsing takes the Gang back to his museum and shows them various jewelry and a glass-faced casket containing the inert body of Valdronya, a centuries-old vampire.
The Joker and the Penguin break out of Arkham Asylum and race each other to find a stash of stolen money hidden within a crypt in Gotham Cemetery after an inmate, who had hidden it, told them about it. The Joker is quickly intercepted by the Batman and is electrocuted when he falls into a river by his super-charged joy buzzers while the Penguin takes the opportunity to enter the cemetery himself. While searching through a crypt, the Penguin accidentally cuts his hand while using his umbrella-sword to open a coffin he hopes contains the money, finding a body instead. Blood from his hand drips on the corpse's heart, which brings it to life; it is none other than the vampire lord Count Dracula, his body having been moved from Transylvania to Gotham City after his "death." After attacking and turning a watchman at the cemetery into a vampire, Dracula hypnotizes the Penguin into becoming his non-vampiric servant so that he may lead him through Gotham to feed and guard his coffin during the day while he regains his strength.
A short time after the first film, Mavis (Selena Gomez) and her fiance Johnny (Andy Samberg) are married, with the approval of her father Dracula (Adam Sandler) and the world has become aware of (and unfased by) the existence of monsters. Mavis later reveals to Drac that she is pregnant and a year later, she gives birth to a son named Dennis (Asher Blinkoff), who befriends Wayne's werewolf pup daughter Winnie (Sadie Sandler). Nearing his fifth birthday, Dennis has yet to grow his fangs and Drac worries that his grandson might not gain vampire powers. Noticing the dangers of Transylvania, Mavis starts to consider raising Dennis where Johnny grew up, much to Drac's disapproval.
The story is set in 1966. Its main protagonist is a girl named Saya, who hunts bat-like creatures called chiropterans. Saya is introduced on a subway train, where she assassinates a man in a suit. Her American contacts or handlers arrive. One of them, David, begins to brief Saya on another mission, while the other, Louis, discovers that the man Saya has just killed was probably not a chiropteran.
A prologue replays the final scenes from Dracula, in which Dr. Van Helsing (Peter Cushing) destroys Dracula (Christopher Lee) by driving him into the sunlight. These scenes are accompanied by voice-over narration that describes how Van Helsing, a scholar of vampirism, was able to end Dracula's century-long reign of terror and destroy his cult; only the memory of Dracula's evil remains.
A gloomy wood is seen as a voice is heard, narrating:
Transylvania, land of dark forests, dread mountains and black unfathomable lakes. Still the home of magic and devilry as the nineteenth century draws to its close. Count Dracula, monarch of all vampires is dead. But his disciples live on to spread the cult and corrupt the world...
Miriam Blaylock (Catherine Deneuve) is a beautiful and dangerous immortal vampire, promising specially chosen humans eternal life as her vampire lovers. As the film begins, her vampire companion is John (David Bowie), a talented cellist whom she married in 18th century France. The film opens in a night club in New York, to a live performance from Bauhaus. There they connect with another young couple who are brought home and fed upon by slashing their throats with a bladed Ankh pendant. The bodies are disposed of by an incinerator in the basement of John and Miriam's elegant New York townhouse, where they pose as a wealthy couple who teach classical music. The only student shown is a young tomboy violinist named Alice Cavender (Beth Ehlers).
Maria and Frieda, recently orphaned identical twin teenage girls, move from Venice to Karnstein in Central Europe to live with their uncle Gustav Weil. Weil is a stern puritan and leader of the fanatical witch-hunting 'Brotherhood'. Both twins resent their uncle's sternness and one of them, Frieda, looks for a way to escape. Resenting her uncle, she becomes fascinated by the local Count Karnstein, who has the reputation of being "a wicked man".
Barrow, Alaska is preparing for its annual "30 Days of Night", a period during the winter when there is a month-long polar night. As the town gets ready, a stranger rows ashore from a large ship. Once ashore, he sabotages the town's communications and transport, destroying all means of communication with, and travel to, the outside world. Barrow's sheriff, Eben Oleson, investigates. Eben learns that his ex-wife, Stella Oleson, missed the last plane and must stay the 30 days. Although they try to avoid one another, when Eben confronts the stranger in the town diner, Stella helps to subdue him and take him to the station house.
Twelve-year-old Goku seeks out Master Roshi to ask to be accepted as a student, while the little monk, Krillin, arrives for the same reason (and uses a porno magazine as a bribe). Roshi sends them on a quest far to the west, where "five mountains stand, called the 'Devil's Hand'." Inside a castle, there lies the legendary, and beautiful, "Sleeping Princess." Whoever brings back the Sleeping Princess will become Master Roshi's student. The two boys set out, and Krillin uses all the standard tricks to trip Goku up.
Baron Boris von Frankenstein (voiced by Boris Karloff) achieves his ultimate ambition, the secret of total destruction. Having perfected and tested the formula, he sends out messenger bats to summon all monsters to the Isle of Evil in the Caribbean Sea. The Baron intends to inform them of his discovery and also to reveal his imminent retirement as head of the "Worldwide Organization of Monsters". Besides Frankenstein's Monster (referred to as "Fang") and the Monster's more intelligent mate (voiced by Phyllis Diller) who live in the island castle with Boris, the invites also include Count Dracula, the Mummy, Quasimodo (referred to as "The Hunchback of Notre Dame"), the Werewolf, The Invisible Man, Dr. Jekyll and Mr. Hyde, and the Creature from the Black Lagoon (referred to as the "Creature").
Five men enter a train carriage in London bound for Bradley, and are joined by a sixth, the mysterious Doctor Schreck (Peter Cushing) whose name, he mentions, is German for "terror". During the journey, the doctor opens his pack of Tarot cards (which he calls his "House of Horrors") and proceeds to reveal the destinies of each of the travellers. This provides the framework to tell five horror stories.
The setting of the film is 1920s London. Sir Roger Balfour is found shot to death in his home. Inspector Burke (Lon Chaney) of Scotland Yard is called in to investigate. The suspects are Williams (the butler), Sir James Hamlin (Henry B. Walthall) and his nephew, Arthur Hibbs (Conrad Nagel). A suicide note is found and the case is supposedly closed.