Smith plays Colette, an ex-CIA agent attempting to track down the leader of an organization of trained assassins to exact revenge for the murder of her husband. Joey Travolta is Frank DaVinci, who is also after the same man for his own reasons. In light of this, they agree to work together to track him down.
At the beginning, Izna, a porn star (Sunny Leone), is lying dead in the grass, but she says that she wants to ask forgiveness from somebody for her sins. The story flashes back six months.
Ten years after Elizabeth (the character portrayed by Kim Basinger in the first film) left him, John has descended into a world of depression and loneliness, and is suicidal. When he receives an invitation to attend an art exhibit in Paris that will feature some of Elizabeth's paintings, he immediately boards a plane for France, hoping to get to talk to her.
In 1986, young Darius Foxx witnessed his mailman father shoot his wife and her secret lover, then himself. Eighteen years later, Darius becomes the new mailman of Smithfield, cryptically informing the townspeople that his predecessor is "out of town" for an indeterminate amount of time.
Anthony is member of a gang. As a revenge for something not clearly said, he gets caught and placed by Jack and another man into a garage. Here Jack is torturing and sexually abusing Anthony. Bruno comes into the garage and is doing the same while Jack is leaving, although he comes back rescues Anthony and both starting in return torturing Bruno. They go away leaving wounded Bruno in the garage. Some times later Anthony lives together with Donna and her gay brother. While they were playing at home, Donna receives a phone call, telling her that her father died. Anthony and Donna decide to drive to the funeral. On their long journey they meet several people. For the nights, they stay in motels and have sexy plays with two male prostitutes, one called in by Anthony. The other called in on the next night by Donna. In their journey they also meet Jack; the second time at a petrol station, where Anthony and Jack have sex in the toilets. Anthony falls for Jack and decides to stay with him, while Donna decided to leave them and is driving home.
Aravindan, a college lecturer, falls in love with his student Radha and marries her. However, the couple's sexual life is a failure, causing intense agony to Radha's father, Panikkar who is keen to have grandchildren. When all other means fail, Panikkar approaches a psychiatrist, who finds out that Aravindan's inability to have sex with Radha may have something to do with his intense affection for his mother, who had died just six months before Aravindan met Radha. How the doctor cajoles Radha into solving her husband's illness forms the climax.
A woman mysteriously develops psychic powers and the ability to contact spirits of the dead. Tōru, her avaricious husband, convinces the woman to hold seances, charging people money to contact their dead. When the King of Hell learns of this business, he kidnaps the wife. Attempting to rescue his wife, Tōru travels to the underworld with a Chinese monk. On the journey they encounter scenes of horror and sexual perversion.