The movie begins with frank, humorous interviews of two men who set out to kill themselves and then moves into a Day Of The Dead celebration where the guests celebrate the lives of those whom they have lost. Director Stutz questions his family about his mother's suicide in 1979 and how little they've actually discussed it, visiting his mother's grave site with his sister and listening to old tapes of their mother. He talks to several survivors and experts before commissioning several artists to come up with works about suicide: A band (The Bigfellas) agrees to make a song about suicide "that you can dance to"; an illustrator (Patrick Horvath) is to make short animated films (which run through the documentary as interstitials); a choreographer (Danielle Peig) chooses to create a dance piece based on two autopsy reports; and a standup comedian (Duncan Trussell) compiles material for his act about suicide with the help of several top comedy writers. Meanwhile, Stutz continues to interview and engage his family about his mother's death, eventually staging his mother's suicide (where he discovered her unconscious at the age of 12) on screen with members of the "avant-garde circus" troupe, The Lucent Dossier Experience.
The film focuses on a new resident, Joe Blackburn, who is 21 and begins the documentary weighing over 30 stone (190 kg, 420 lbs) and with fears for his health. The plot follows his struggle to integrate with existing members of the home.
“Shadows and Illuminations” paints a portrait of Nyoman Kereta, a rural Balinese man in his late sixties who, by psychiatric standards, suffers from a psychotic-like illness. He experiences auditory and visual hallucinations that are a source of great distress, prevent him from tilling his rice fields, and isolate him from his family and fellow villagers. Through the lens of local Balinese standards, he is seen as haunted by spirit visitations that villagers interpret within the frame of their culture and religion.